Protein Alignment Pde8 and pde3a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_031753954.1
• Gene: pde3a / 101730602
• XenbaseID: XB-GENE-6033578
• Length: 1022
• Species: Xenopus tropicalis
• Alignment Length: 592
• Identity: 161/592 - (27%)
• Similarity: 233/592 - (39%)
• Gaps: 173/592 - (29%)

  Fly   522 VRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFD 586
            |..|.::|||.::..:...|  .:|        :||..    |..|..|..|      |:.|
 Frog   383 VTPKWRQGIPPNISPLISPC--QSP--------IPGTP----AASPTVKSLP------VQFC--- 424

  Fly   587 VRSIASDGLRRTSLAKLTSLPLEAPITKIINLLSQVQE-------------NCSADEARLIDKVL 638
                  ||   |.|.:|...|     .|:::......|             :|...
 Frog   425 ------DG---TELGRLGPNP-----HKVLSSTKSAPEIPEPFPGSTLVCASCGRS--------- 466

  Fly   639 EFLKREGLYSP-------------QMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDS----II 686
                    |||             ...:.|||||..|         .|.|.|...:|.|    |:
 Frog   467 --------YSPVNPSDGALDPGEVPHSQNRTDDPTHT---------TSDYDSTHETNHSDSSDIL 514

  Fly   687 ---------------RTGSSTRTAAIVP-------AKMKSNPIIMELLD----ESLSWDFDIFKL 725
                           ::.:|.:...:.|       |.:...|::||.||    |..:|:|.||.|
 Frog   515 PSDEPDGAKDPAQSRKSSASFQGEVLHPLIHSEEKAVLAPEPLLMEDLDSLMGEINNWNFPIFDL 579

  Fly   726 EEITDYHPLLYLGMEMFRRFD---VFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQA 787
            .|.|.......|....:|.|:   :..|..|.......:...:|:.|| ...|||..||.||:.|
 Frog   580 VEKTGQKTGRILSQVSYRLFEDMGLLETFKIPLREFMNYFHALESGYR-DIPYHNRIHATDVLHA 643

  Fly   788 TGAFITQ-----------------------LTNKDM-LVMDRME-----------------EATA 811
            .....||                       :|:..| .|..:|.                 |..|
 Frog   644 VWYLSTQAIPGLPNAVSEQGSASDSDSDSGITHGHMGYVFSKMYNPSDDTYGCLSGNIPSLELMA 708

  Fly   812 L-IAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKET 875
            | :|||.||.|||||::|||..:|...||||||.:||||||||..:.|.|...:.|...|||...
 Frog   709 LYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAAAAWNLFLSRPEYNFLVNLDHME 773

  Fly   876 YKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTD---EETSILMRRMLIKVADVS 937
            :|..|..:|:.||||::.:||:.||:|.:...||.    :|..|   |...:|:.:|.||:||::
 Frog   774 FKRFRFLVIEAILATDLKKHFDFLAEFNAKVNGEV----SPGIDWSNENDRLLVCQMCIKLADIN 834

  Fly   938 NPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAW 1002
            .||:.....::|...|..|::.|.|||....||| .|..||:...:.|.|..||.:|:..:.|::
 Frog   835 GPAKFKDLHLKWTEGIVNEFYEQGDEESSLGLPI-SPFMDRSAPQLAKLQESFITHIVGPLCHSY 898

  Fly  1003 ESFIDMP 1009
            :|...||
 Frog   899 DSAGLMP 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	5/16 (31%)
		PAS_9	463..539	CDD:290162	5/16 (31%)
		PDEase_I	775..1016	CDD:278654	98/280 (35%)
pde3a	XP_031753954.1	PRK07764	<19..209	CDD:236090
		PDEase_I	631..894	CDD:395177	94/267 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010