DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and pde1cb

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_017207862.1	Gene:	pde1cb / 100536162	ZFINID:	ZDB-GENE-090902-2	Length:	698	Species:	Danio rerio

Alignment Length:	438	Identity:	124/438 - (28%)
Similarity:	214/438 - (48%)	Gaps:	51/438 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 VRSIASDGLRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLID--KVLEFLKR--EGLY 647
            :..|.:|.|..|...:.|    |....::..|:.|::..    ||.|:|  |.||:...  |.:|
Zfish   115 IEEILADELPSTDTPEAT----EKTAVRLRCLVKQLERG----EASLVDLKKNLEYAATVLESVY 171

  Fly   648 SPQMKE-IRTDD---PIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPA-------- 700
            ..:.:. :.|:|   .|.:|.:.:.:......:..|.....:.||....|..:||.|
Zfish   172 IEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRTEEKPRFRSIVHAVQAGIFVE 236

  Fly   701 ---KMKSN-------PIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDE 755
               :..||       |.::.:|.....|.||:|.|.|.:..|.|.::..|:..|:|:.:...|..
Zfish   237 RMYRRTSNMVGLSYPPNVIAVLKNVDRWSFDVFALNESSGDHALKFIFYELLTRYDLISRFKIPV 301

  Fly   756 NVCKAWLAVIEAHYRK-SNTYHNSTHAADVMQATGAFITQLTNKDMLV--MDRMEEATALIAAAA 817
            :...:::..:|..|.| .|.|||..|||||.|.    :..|..|..:|  |..:|....:.|||.
Zfish   302 SALVSFVEALEVGYSKYKNPYHNLIHAADVTQT----VHYLLLKTGMVHWMTELEIFAMIFAAAI 362

  Fly   818 HDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARST 882
            ||.:|.|.::.|...:....|:||||.:|||:||.:.:::|...||::||..||.|:.::..|:.
Zfish   363 HDYEHTGTTNNFHIQTRSDAAILYNDRSVLESHHVSASYRLLQDDDEMNILYNLSKDDWREFRAL 427

  Fly   883 IIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCI 947
            :::|:|||:|:.||:.:....:..  ::|..    .|:..:|   .:|:..||:|:||:......
Zfish   428 VVEMVLATDMSCHFQQVKAMKNYL--QQPEG----IDKPKAI---SLLLHAADISHPAKTWDLHH 483

  Fly   948 EWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYII 995
            .|...:.||:|:|.|:|.:..||. .|:.||.:..:.:||||||::|:
Zfish   484 RWTTSLLEEFFLQGDKEAELGLPF-SPLCDRKSTMVAQSQIGFIDFIV 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	76/223 (34%)
pde1cb	XP_017207862.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589323
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850