DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and pde7a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_031760262.1	Gene:	pde7a / 100498541	XenbaseID:	XB-GENE-1013813	Length:	480	Species:	Xenopus tropicalis

Alignment Length:	329	Identity:	99/329 - (30%)
Similarity:	167/329 - (50%)	Gaps:	39/329 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   711 LLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTY 775
            :|::..||.||||..:.:|:.:.|:.|...:.....:.....:|....:.:|.:::..|...|.|
Frog   162 MLEKVGSWSFDIFLFDRLTNGNSLVTLTFHLLSHHGLIDHFQLDMVKLRRFLVMVQEDYHSQNPY 226

  Fly   776 HNSTHAADVMQATGAFITQ------LTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSN 834
            ||:.|||||.||...|:.:      .|..|:|:        .|||||.||:||||.:.:||..:|
Frog   227 HNAVHAADVTQAMYCFLKEPKLAKSFTPWDILL--------GLIAAATHDLDHPGVNQSFLIKTN 283

  Fly   835 DALAVLYNDLTVLENHH--AAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFE 897
            ..||.||.:.:||||||  :|:......|     :|.::..|..:.....:..:||||:::|..|
Frog   284 HYLATLYKNTSVLENHHWRSAVGLLRESG-----LFAHMTLEERQHMEGQLGSIILATDISRQNE 343

  Fly   898 HLAKFVSVFGGEEPRDHNPQTD-----EETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEY 957
            :|::|         |.|..:.|     ....:.:.:|.:|.||:.||.|..:...:|:.::.||:
Frog   344 YLSQF---------RTHLDRGDLCLDNASDRLFILQMALKCADICNPCRTWELSKQWSEKVTEEF 399

  Fly   958 FMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFID---MPQLITYMQINY 1019
            |.|.|.|::..|. |.|:.||.|.:|...|||||.|:::.:...|..|.:   ...::.::.:|.
Frog   400 FYQGDVERKYKLD-VSPLCDRQTSNIANIQIGFITYLVEPLFVEWARFSNTRLSQTMLGHVGLNK 463

  Fly  1020 SQWK 1023
            :.||
Frog   464 ASWK 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	82/256 (32%)
pde7a	XP_031760262.1	PDEase_I	226..459	CDD:395177	82/255 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010