Protein Alignment Pde8 and pde8a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_012814959.2
• Gene: pde8a / 100497070
• XenbaseID: XB-GENE-6051349
• Length: 876
• Species: Xenopus tropicalis
• Alignment Length: 896
• Identity: 323/896 - (36%)
• Similarity: 474/896 - (52%)
• Gaps: 112/896 - (12%)

  Fly   216 DGSTDPKGERNHAEEEPLTPGHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAGKKNP 280
            |.|..|......|::....||...:.|.....||     :|:|..:.|....|.:...:....|.
 Frog    23 DDSNSPHQTNTLAQQGNSVPGLFIKSSHTSTYKV-----RANSSRKGRRENSPSMEAEINSSTNS 82

  Fly   281 PTE-----------EEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQL 334
            .|.           :...|..|...|.|:       ...|:.||||.|.||.......||::...
 Frog    83 STNSSTNSSTSTAVKAAVREVQFGPMKLR-------QDQLQVLLVFAKEDSQSNGFCWACEKAGF 140

  Fly   335 DVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKS 399
            ...:.::.|.||::....:     :.:||||.|.|:..|||.:.|:||.|.....|.|:||.::.
 Frog   141 KCNIARTPETALESFLDKH-----HEIIIIDHRHSRYFDAEALCRSIRATKPSENTVIVAVVRRQ 200

  Fly   400 FFEKDDVLIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVL 464
            ....:..::.|:.||..|...|.:|:..|..||.|:....:.....:....:|:|.|.:.:|.:.
 Frog   201 SDRDEASIMPLISAGFTRRYVENSNIMACYNELIQLEFGEVLAQFKLRACNSLFTTLEKSQEAIE 265

  Fly   465 ITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSD-----LSTISEQCKNIKEFDGILTVRR 524
            ||.:...|||.|.|.|..:..:.||:|.|:|.::.:::     |.||:...|..||::||...:.
 Frog   266 ITSEDHIIQYVNPAFESTMGYQKDELIGKELTEVPINEKKSDFLDTINCCIKTGKEWEGIYYAKN 330

  Fly   525 KSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQP--------KEAPRGSLHS-- 579
            |:.:.|..:|:::||  .|..            |::....::.:|        |:..|....|
 Frog   331 KNGDNIQQNVKIIPV--FGHR------------GKIRHYVSISRPCSDNNKAEKQCERVQAESQT 381

  Fly   580 -VRRC--------SFDVRSIASDG-----------------LRRTSLAKLTSLPLEAPITKIINL 618
             ::.|        |.||||..|.|                 .|.:|:|::.|:.:||||||:||:
 Frog   382 DIQTCRHKDRRKGSLDVRSTTSRGSDGPAEFSHGALPGSSQRRHSSMARIHSMTIEAPITKVINI 446

  Fly   619 LSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSND 683
            ::..|||..:..|..:|:|||.|:...|||||: ..:.:||...||:|.|:|.    ..||.|.:
 Frog   447 INAAQENSPSPVAEALDRVLEILRTTELYSPQL-GTKDEDPHTNDLVGGLMTD----GLRRLSGN 506

  Fly   684 SIIRTGSSTRTAA--IVPAKMKSN--PIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRR 744
            ..|.:.......:  ::.|...|:  |.|.:.:|....|:||||:||..|...||:|||::||.|
 Frog   507 EYILSAKQVHPVSGHMILALSLSDIPPRIAQAMDNEEDWEFDIFELEAATHKRPLVYLGLKMFAR 571

  Fly   745 FDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEA 809
            |.|...||..|...::||.|||::|..||.||||||:|||:.||..|:.:...|..|  |:::|.
 Frog   572 FGVCQFLNCSEATLRSWLHVIESNYHSSNAYHNSTHSADVLHATAYFLCKERVKQSL--DQIDEV 634

  Fly   810 TALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKE 874
            .|||||..||||||||:::||||:...||:||||..|||:||||:.|:||..|||.|||||:::.
 Frog   635 AALIAATVHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTRDDKCNIFKNMERN 699

  Fly   875 TYKSARSTIIDMILATEMTRHFEHLAKFVSVF----------GGEEPRDH---NPQTDEETSILM 926
            .|::.|..||||:||||||:||||:.|||:..          ||....|.   |..|..|..||:
 Frog   700 EYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPLAAVEENGGSIEEDEAVKNILTSPENRILI 764

  Fly   927 RRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFI 991
            :|||||.||:|||.|.::.|||||.||:||||.||||||::.||:|||:|||.|||||||||.|:
 Frog   765 KRMLIKCADISNPCRALEQCIEWAGRISEEYFAQTDEEKRKGLPVVMPVFDRNTCSIPKSQISFV 829

  Fly   992 EYIIQDMMHAWESFIDMPQLITYMQINYSQWKKYDEQGVNTLAEIMAKQPP 1042
            :|.|.||..||::|.|:|.|:.::..|:..||..||:.:.||     :.||
 Frog   830 DYFITDMFDAWDAFADLPNLMQHLDNNFKYWKSLDERQLKTL-----RPPP 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	25/84 (30%)
		PAS_9	463..539	CDD:290162	24/80 (30%)
		PDEase_I	775..1016	CDD:278654	140/253 (55%)
pde8a	XP_012814959.2	PDE8	1..48	CDD:400795	6/24 (25%)
		PAS	151..360	CDD:225112	61/227 (27%)
		PAS_9	262..360	CDD:404329	29/111 (26%)
		PDEase_I	602..854	CDD:395177	140/253 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1585
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	531	1.000	Inparanoid score	I1192
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80286at33208
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm47491
Panther	1	1.100	-	-	O	PTHR11347
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160