DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and pde4d

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_031749923.1	Gene:	pde4d / 100496479	XenbaseID:	XB-GENE-1013100	Length:	912	Species:	Xenopus tropicalis

Alignment Length:	585	Identity:	161/585 - (27%)
Similarity:	248/585 - (42%)	Gaps:	145/585 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   553 FDVPGGQMDFIATLPQPKEAPRGSL-------HSVRRCSFDVR----------------SIASD- 593
            |||..|.....:.| .|..:|...|       ||.||.||..|                |||||
Frog   261 FDVDNGTTSGRSPL-DPMTSPGSGLILQANFVHSQRRESFLYRSDSDYELSPKSMSRNSSIASDI 324

  Fly   594 ---------------GLR--RTSLAKLTSLPLEAP-----------ITK---------------- 614
                           .||  |.:.|.||:|...||           |.|
Frog   325 HGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSTMCNQPSINKATIPEEAYQKLAGETL 389

  Fly   615 -----IINLLSQVQENCSADE------ARLIDKVLEFL---KREG-------------------L 646
                 .::.|..:|...|..|      .|::::.|..|   .|.|                   :
Frog   390 EELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEM 454

  Fly   647 YSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMEL 711
            .||..||........:.:.|.    ..:..|...:|.:|.|.|          .|.::...:.:.
Frog   455 PSPAQKEKEKKKRPMSQISGV----KKLMHSSSLTNSNIPRFG----------VKSENEECLAKE 505

  Fly   712 LDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYH 776
            |::...|..:|||:.|.:...||..:...:|:..::..|..|..:....:|..:|.||.....||
Frog   506 LEDVNKWGLNIFKVAEFSGNRPLTVVMHTIFQEREMLKTFKIPVDTLITYLMTLEDHYHADVAYH 570

  Fly   777 NSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLY 841
            |:.|||||.|:|...::....:  .|...:|...|:.|:|.|||||||.|:.||.|:|..||::|
Frog   571 NNIHAADVAQSTHVLLSSPALE--AVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMY 633

  Fly   842 NDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVF 906
            ||.:||||||.|:.||| |.::..:||:||.|:..:..|..:||::|||:|::|...||...::.
Frog   634 NDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQLLRKMVIDIVLATDMSKHMNLLADLKTMV 697

  Fly   907 GGEEPRDHNPQTDEETS------------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFM 959
                      :|.:.||            |.:.:.::..||:|||.:|:.....|..||.||:|.
Frog   698 ----------ETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLPLYRHWTDRIMEEFFR 752

  Fly   960 QTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFI--DMPQLITYMQINYSQW 1022
            |.|.|::|.:.| .||.|:...|:.|||:|||:||:..:...|...:  |...::..::.| .:|
Frog   753 QGDRERERGMEI-SPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDN-REW 815

Fly 1023 1022
Frog 816 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	93/254 (37%)
pde4d	XP_031749923.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010