DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and pde1c

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_031759760.1	Gene:	pde1c / 100495383	XenbaseID:	XB-GENE-994226	Length:	762	Species:	Xenopus tropicalis

Alignment Length:	474	Identity:	128/474 - (27%)
Similarity:	220/474 - (46%)	Gaps:	62/474 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   549 LIFNFDVPGGQMDFIATLPQ-PKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSL--PLEA 610
            :|...::...|...|||.|: |:|.....|..|.         :.|.:.:.|: :|..|  .||.
Frog    57 IISGLNLKEKQKPAIATDPRSPEEILADELPQVD---------SPDAIPKASI-RLRCLVKQLER 111

  Fly   611 PITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDD--PIATDLIGALLTGPS 673
            ....:::|...::...:..|:..||:....|..|    .::.:|::|.  ....|.:.:..|
Frog   112 GEASVVDLKKNLEYAATVLESVYIDETRRLLDTE----DELSDIQSDSVPSEVRDWLASTFT--- 169

  Fly   674 VYSSRRSSNDSIIRTGSSTRTAAIVPA-----------KMKSN-------PIIMELLDESLSWDF 720
                 |.....:.||....|..:||.|           :..||       |.::.:|.....|.|
Frog   170 -----RQMGMMLKRTEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIAVLKNVDKWSF 229

  Fly   721 DIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRK-SNTYHNSTHAADV 784
            |:|.|.:.:..|.|.::..|:..|:|:.....|..:...:::..:|..|.| .|.|||..|||||
Frog   230 DVFALNDASGDHGLKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYTKHKNPYHNLIHAADV 294

  Fly   785 MQATGAFITQLTNKDMLV--MDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVL 847
            .|....|:.    |..||  :..:|....:.|||.||.:|.|.::.|...:....|:||||.:||
Frog   295 TQTVHYFLF----KSGLVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDSAILYNDRSVL 355

  Fly   848 ENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPR 912
            ||||.:..::|...|:::||..||.|:.::..|:.:|:|:|||:|:.||..:.:..:..
Frog   356 ENHHVSAAYRLLQDDEEMNILYNLSKDDWREFRALVIEMVLATDMSCHFHQIKQMKNAL------ 414

  Fly   913 DHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFD 977
             ..|:..::...|  .:|:..||:|:||:.......|...:.||:|.|.|:|.:..||. .|:.|
Frog   415 -QQPEGIDKPKAL--SLLLHTADISHPAKNWDLHHRWTMSLLEEFFRQGDKEAELGLPF-SPLCD 475

  Fly   978 RATCSIPKSQIGFIEYIIQ 996
            |.:..:.:||||||::|::
Frog   476 RNSTMVAQSQIGFIDFIVE 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	76/224 (34%)
pde1c	XP_031759760.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010