DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and XB990243

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_012822440.1	Gene:	XB990243 / 100493061	XenbaseID:	XB-GENE-990244	Length:	521	Species:	Xenopus tropicalis

Alignment Length:	550	Identity:	150/550 - (27%)
Similarity:	234/550 - (42%)	Gaps:	104/550 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   526 SQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSI 590
            ||...|..::.:..|..|......|...|..|..:...:|:|:..   :.|.:.:...|...|..
Frog    27 SQHSSPAEIKELLCASAGLPWQAAIILLDKKGTVVATDSTIPKNS---KSSAYRIVSRSISPRPE 88

  Fly   591 ASDGLRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIR 655
            ..|..:                    |:||||.|..|.     ..:|.| :|||.:....|.|.|
Frog    89 KEDFFQ--------------------NILSQVTEEFSR-----AFRVTE-MKREVMERLAMLERR 127

  Fly   656 TDDPIATDLIGALLTGPSVYSSRRSSND-SIIRTGSSTRTAAI-VPAKM-------KSNP----- 706
            .:           :.|.......:..|: ..:|.....:|:.: .|.:.       |.||
Frog   128 ME-----------VEGLKAIDIDKCKNELKNLRDEMEKKTSRLSCPCRFYYSEDIKKLNPRRDVP 181

  Fly   707 ------IIMELLDESLSWDFDIFKLE--EITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLA 763
                  :..|.:|......||::..|  |:......:|..:.:.|.|      |::....|.||.
Frog   182 TYPKYTLSSETIDALKKPTFDVWHWEYNEMLSCLEFMYHDLGLVREF------NMNPITLKRWLL 240

  Fly   764 VIEAHYRKSNTYHNSTHAADVMQATGAFI--TQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRS 826
            .|:.:|| :|.:||..|...|.|.....|  ..|..|    |..:|....:.:|..||:||||.:
Frog   241 CIQENYR-TNPFHNFRHCFCVTQMMYGMIHLCNLQEK----MSLIELGVLMTSAVCHDLDHPGYN 300

  Fly   827 SAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATE 891
            :.:..|::..||:.|||::.|||||.|:.|:: |...:.|||.|:..|.:|..|.:||.:||||:
Frog   301 NTYQINAHTELAIRYNDMSPLENHHCAVAFQI-LAQPENNIFANITPELFKQIRQSIIRLILATD 364

  Fly   892 MTRHFEHLAKFVSVFGGEEPRDHNPQTD---EETSILMRRMLIKVADVSNPARPMQFCIEWARRI 953
            |.||.|.|..|..|.         |..|   |:....::.:|||..|:||..||.:....|...:
Frog   365 MARHGEILESFKKVL---------PNFDFSNEDHVKTLQMVLIKCCDISNEVRPTKVAEPWVDCL 420

  Fly   954 AEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDM-PQLITYMQI 1017
            .||||||:|.||...|| |.|..||...:.||:|||||::::..|   :||.:.: |.:...|.:
Frog   421 LEEYFMQSDREKSEGLP-VTPFMDRDKVTKPKAQIGFIKFVLIPM---FESVMKLFPHIEEVMVL 481

  Fly  1018 -------NYSQWKKYDEQGVNTLAEIMAKQ 1040
                   :|.:..:.:|    .|||:..|:
Frog   482 PLREARDHYEELMEIEE----ALAEVQQKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	3/12 (25%)
		PAS_9	463..539	CDD:290162	3/12 (25%)
		PDEase_I	775..1016	CDD:278654	89/246 (36%)
XB990243	XP_012822440.1	GvpK	<110..>153	CDD:282916	11/54 (20%)
XB990243	XP_012822440.1	PDEase_I	251..479	CDD:278654	89/245 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950