DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and pde8b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_002940920.1	Gene:	pde8b / 100490787	XenbaseID:	XB-GENE-994976	Length:	870	Species:	Xenopus tropicalis

Alignment Length:	763	Identity:	311/763 - (40%)
Similarity:	451/763 - (59%)	Gaps:	60/763 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 PLKALLVFHKSDSICEAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNL 372
            |::.||||.|.||..:....||.|......:.::.|.|::.....:     :.:|:||.|.|:.|
Frog   114 PIQVLLVFAKEDSQSDGFWWACDRAGYRCNIARTPESAVECFLDKH-----HEIIVIDHRHSRYL 173

  Fly   373 DAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDV-LIALLDAGVNRCVAETTNLAMCSVELKQIL 436
            |||.:.|:||.|.....|||:||..:...::::: ::.||:.|.||...|.:::..|..||.||.
Frog   174 DAEAVCRSIRATKPSEHTTILAVVPRVASDQEEMSVLPLLNVGFNRRFVENSSMIACYNELIQIE 238

  Fly   437 HSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVS 501
            |..:|....:.:..:::|||...:|.:.||.:...|||.|.|.||::....:|:|.|:|.::..|
Frog   239 HGEVRSQFKLRSCNSIFTALDNCQEAIEITSEDHIIQYVNPAFERMMGYHKEELIGKELTELPKS 303

  Fly   502 D------LSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLI-----FNFDV 555
            |      |.||:...|..||:.||...||||.:.|..||:|.||...|....|.:     .|.:.
Frog   304 DKNRADLLDTINTCIKKGKEWQGIYFARRKSGDSIQQHVKVTPVIGQGGKIRHFVSIKKLCNSND 368

  Fly   556 PGGQM------DFIATLPQPKEAPRGSLHSVRRCSFDVRSIAS--------DGLRRTSLAKLTSL 606
            ...|:      |...|     |:....|.:.|:.|.|||||.|        ...|.:|:|::.::
Frog   369 NNKQIYKVNREDNALT-----ESHSFRLKNRRKESVDVRSITSRSSDAPSLQNHRYSSMARIHTM 428

  Fly   607 PLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTG 671
            .:||||||:||:::..|||.....|..:|:|||.|:...|||||: ..:.:||..:||:|.|:|.
Frog   429 TIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQL-GTKDEDPHTSDLVGGLMTD 492

  Fly   672 PSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSN---PIIMELLDESLSWDFDIFKLEEITDYHP 733
                ..||.|.:..:.:.:...:.:.:...:..|   |.|.|||::.:||||:||:||.:|...|
Frog   493 ----GLRRLSGNEYVFSKNVHHSHSHLSVPITINDVPPCIAELLEDEVSWDFNIFELEAVTIKRP 553

  Fly   734 LLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNK 798
            |:|||:::|..|.....||..|...::||.::||:|..||.||||||||||:.||..|:.|...|
Frog   554 LVYLGLKIFTCFGACEFLNCSEVTLRSWLQLVEANYHASNAYHNSTHAADVLHATAFFLQQENVK 618

  Fly   799 DMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDD 863
            ..|  |::::..|||||..||||||||:::||||::..|||||||..|||:||||:.|:||..|:
Frog   619 GSL--DQLDKVAALIAATVHDVDHPGRTNSFLCNASSELAVLYNDTAVLESHHAALAFQLTAKDN 681

  Fly   864 KINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVS----VFGGEEPRDHNPQTDEETS- 923
            |.|||||:|:..|::.|..||||:||||||:||||:.|||:    ....|:...::..:|.|.|
Frog   682 KCNIFKNMDRTQYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPIAAEDSNSNSEGSDFECST 746

  Fly   924 ---------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRA 979
                     ||::||:||.|||:||.||:..|||||.||:||||.||||||::.||:|||:|||.
Frog   747 NIRNSPENRILIKRMMIKCADVANPCRPLNLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRN 811

  Fly   980 TCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQINYSQWKKYDE 1027
            |||||||||.||:|.|.||..||::|..:|.||.::..||..||..||
Frog   812 TCSIPKSQISFIDYFITDMFDAWDAFAHLPNLILHLTDNYKYWKSLDE 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	32/85 (38%)
		PAS_9	463..539	CDD:290162	31/81 (38%)
		PDEase_I	775..1016	CDD:278654	141/254 (56%)
pde8b	XP_002940920.1	PDE8	1..47	CDD:285793
		PAS_9	263..360	CDD:290162	36/96 (38%)
		PAS	267..360	CDD:238075	35/92 (38%)
		PDEase_I	595..847	CDD:278654	141/253 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1585
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2758
Inparanoid	1	1.050	531	1.000	Inparanoid score	I1192
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80286at33208
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm47491
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160