DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pde8 and pde6a

DIOPT Version :9

Sequence 1:NP_001163275.2 Gene:Pde8 / 37741 FlyBaseID:FBgn0266377 Length:1050 Species:Drosophila melanogaster
Sequence 2:XP_002936750.3 Gene:pde6a / 100489913 XenbaseID:XB-GENE-988755 Length:866 Species:Xenopus tropicalis


Alignment Length:906 Identity:203/906 - (22%)
Similarity:342/906 - (37%) Gaps:285/906 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   343 EEALDTLQKSYATAQCYHL-----IIIDARSSK--NLDAEHIARTIRHTHGHHLTTIIAVCKKSF 400
            |:.||: ..|:| .|.|.|     ||.|..|::  |:|..|:         |.|:::        
 Frog    10 EKFLDS-NPSFA-KQYYDLKFRPGIICDLLSTERTNVDFSHV---------HTLSSV-------- 55

  Fly   401 FEKDDVLIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLI 465
             |:.:::..|:     |...|..||..|...:.:::..||:     :.:.:|:  ::|::...  
 Frog    56 -EESEIVFDLI-----RGFQENLNLERCVFSVLKMMSFIIQ-----ADRMSLF--MYRMRNGT-- 105

  Fly   466 TDDLLRIQYANRATERLLNMR----LDEII---------------------SKQLEDIFVSDLST 505
                     |..|| ||.|:.    |||.:                     ||:|  :.|||::.
 Frog   106 ---------AELAT-RLFNVNKDATLDECVVVPDSEIVFPLDTGVLGYVAQSKKL--VNVSDVTQ 158

  Fly   506 ISEQCK---NIKEFDG-----------------ILTVRR-------KSQEGIPMHVRVVPVACIG 543
            .|..|.   |:.|:|.                 |:.|.:       |:.|  .|.::.:..|.:.
 Frog   159 DSHFCSFVDNLTEYDTKSILAAPVLNGKDVVAVIMAVNKSDGTNFTKTDE--EMFLKYLSFANLV 221

  Fly   544 SAPTHL--IFNFDVPGGQM------DFIATLPQPKEAPRGSLHSVR---RCS------------- 584
            ....||  :.|.:...||:      .....|...:.....:|::||   .|.             
 Frog   222 LKVYHLSYLHNCETRRGQILLWSANKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKTK 286

  Fly   585 --FDVRSI------------ASDGLRRTSLAKLTSLPLEA-PITKII------------NLLSQV 622
              ||...|            ..|| |..|..|:....|.. ...|:|            .|.|.|
 Frog   287 EFFDQWPILMGEVPPYSGPKTPDG-REISFYKVIDYILHGKEEIKVIPNPPADHWSLVSKLPSYV 350

  Fly   623 QEN---C-----SADE---------------------ARLIDKVLEFL-------KREGLYSPQM 651
            .||   |     ||||                     ..:::|..|.|       :::|....:|
 Frog   351 AENGLICNIMNTSADEYFDFQKGPVDDSGWIMKNVLSMPIVNKKEEILGVATFYNRKDGKPFDEM 415

  Fly   652 KEIRTDDPIATDLIGALLTGPSVYSSR------------------RSSNDSIIRTGSSTRTAAIV 698
            .|:.|:.  .|..:|..:.....|...                  :.|||.:         ..|:
 Frog   416 DEVLTES--LTQFLGWSVLNTDTYEKMNKLENRKDIYQDMVNYHVKCSNDEL---------QIIL 469

  Fly   699 PAKMKSNPIIMELLDESLSWDFDIFKLE-------EITDYH----PL--LYL---GMEMFRRFDV 747
            ..|...|.:..|..:|.|   ::|.:.|       ||.::|    |:  |:|   .::::...:|
 Frog   470 KTKEIYNRLPEECEEEEL---YEILQEELPDPTEAEIYEFHFSDLPVSELFLVKCAIQIYYELEV 531

  Fly   748 FATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRME----- 807
            ....:|.:.|...:|..:...|||. ||||..|..:|.|      |..|   :|:...::     
 Frog   532 VDKFHIPQEVLVRFLFSVSKGYRKI-TYHNWRHGFNVGQ------TMFT---LLMTGNLKRYYTD 586

  Fly   808 -EATALIAAA-AHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITF-KLTLGDDKINIFK 869
             ||.|::.|| .||:||.|.::.:...|...||.|:.. ::||.||  :.| |..|.|:.:|||:
 Frog   587 LEAMAMVTAAFCHDIDHRGTNNLYQMKSGHPLAKLHGS-SILERHH--LEFGKFLLKDESLNIFQ 648

  Fly   870 NLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSV------FGGEEPRDHNPQTDEETSILMRR 928
            ||::..|..|...:...|:||::..:|:..|.|..:      |..|:........::....::..
 Frog   649 NLNRRQYDHAIHMMDIAIIATDLALYFKKRAMFQKIVDQSQTFTSEKDWTEYMMLEQTRKEIVMA 713

  Fly   929 MLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQ--RHLPIVMPMFDRATC-SIPKSQIGF 990
            |::...|:|..|:|.....:.|..:|.|::.|.|.|:.  :..||  ||.||... .:||.|.||
 Frog   714 MMMTACDLSAIAKPWDIQSKVALLVAAEFWEQGDLERTVLQQNPI--PMMDRNKADELPKLQCGF 776

  Fly   991 IEYIIQDMMHAWESF-IDMPQLITYMQINYSQWKK----YDEQGVNTLAEIMAK----QPP 1042
            |:::...:...:..| .::..:...:..|..:|||    ||.: :.||.|...|    |||
 Frog   777 IDFVCTFVYKEFSRFHPEIQPMYDGILNNKKEWKKLADEYDAK-MKTLEEDKQKKEGIQPP 836

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde8NP_001163275.2 PAS 459..539 CDD:238075 25/131 (19%)
PAS_9 463..539 CDD:290162 25/127 (20%)
PDEase_I 775..1016 CDD:278654 70/258 (27%)
pde6aXP_002936750.3 GAF 73..232 CDD:214500 35/181 (19%)
GAF 254..441 CDD:214500 35/189 (19%)
PDEase_I 558..802 CDD:395177 70/257 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D904682at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

Return to query results.
Submit another query.