DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and pde9a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_002944249.2	Gene:	pde9a / 100488870	XenbaseID:	XB-GENE-5917012	Length:	344	Species:	Xenopus tropicalis

Alignment Length:	335	Identity:	103/335 - (30%)
Similarity:	161/335 - (48%)	Gaps:	35/335 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   687 RTGSSTRTAAIVPAKMKSN---PIIMELLDESLSW-DFDIFKLEEITDYHPLLYLGMEMFRRFDV 747
            ||..|:...:.|||. |.|   ..|.|...|:|.. .|::..:|.    ..:|.|...||.:.|:
Frog     4 RTEQSSDPPSNVPAP-KGNQHRTQIPEGTREALKRPTFNVLGMER----PQMLSLLEHMFYQLDL 63

  Fly   748 FATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQ------LTNKDMLVMDRM 806
            .||..::....:.:|:.::.||:: |.:||..|...|.|.....|:|      |...|.|.|
Frog    64 VATFKMEPETLRCFLSSVQEHYQE-NPFHNFHHGFSVAQMLYCVISQCQLQERLLPSDTLAM--- 124

  Fly   807 EEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNL 871
                 ::||..||:||||.|:::..|:...||..||..:.|||||.|:|.:: |..:|.|:..|:
Frog   125 -----MVAALCHDLDHPGLSNSYQVNAQTDLAKRYNYNSPLENHHWAVTLRI-LSQEKSNLLVNV 183

  Fly   872 DKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADV 936
            ..|.....:..|:::||||:|..|.:.|.....:       :....::.|....:::.|||:.|:
Frog   184 APEQLPHIQQEIMELILATDMVHHGKILQSLQHI-------ETLSFSNREHVTALKKTLIKLCDI 241

  Fly   937 SNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHA 1001
            ||.|||......||..:.||||:|:|.||...|| |.|..||.......:|..||.:::..:..|
Frog   242 SNEARPADQAEVWADSLMEEYFLQSDREKAEGLP-VTPYMDRDRVRKADAQSSFITFLLLPLCEA 305

  Fly  1002 WESFIDMPQL 1011
            ...  .:|||
Frog   306 LCQ--HLPQL 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	78/243 (32%)
pde9a	XP_002944249.2	PDEase_I	90..317	CDD:365964	78/243 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920