DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and pde6b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_012808736.2	Gene:	pde6b / 100487945	XenbaseID:	XB-GENE-961019	Length:	859	Species:	Xenopus tropicalis

Alignment Length:	856	Identity:	173/856 - (20%)
Similarity:	332/856 - (38%)	Gaps:	194/856 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 EAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRH---- 383
            |.|.||..|..|.|.....:|  |..:::|    :....::.|.:.|.|:: :.:.:|:|.
Frog    35 ETIAAAFGRKDLTVDFATFRE--LVQVEES----EILFELVNDMQESINME-KVVFKTLRRISFL 92

  Fly   384 THGHH---------------LTTIIAVCKKSFFEK-----DDVLIALLDAGVNRCVAET------ 422
            .|...               .|.:..|...|..|:     |..::..||.|:...||.|
Frog    93 IHADRCSLFMYRQRNGTPELATRLFNVKSNSKLEECLVPPDSEIVYPLDIGIVGHVAHTKKTINV 157

  Fly   423 TNLAMCSV-----------ELKQILHS-IIRPHNVMSTQQALYTALHRLKEVVLIT-DDLLRIQY 474
            .:::.|:|           |.|.||.: |:...:|:    |:..|:::|....... |:.:.::|
Frog   158 KDVSECTVYSKFADELTDYETKNILATPILNGKDVV----AVIMAVNKLDGPFFTNYDEEVFLKY 218

  Fly   475 ANRATERLLNMRLDEI--------------------ISKQLEDI---FVSDLSTISEQCKNIKEF 516
            .|.|:   ||:::..:                    :.::|.||   |.....|:.......:..
Frog   219 LNFAS---LNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCDRYS 280

  Fly   517 DGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQ-------MDF-------IATLP 567
            .|:|.:.::.:     ...|.|| .:|..|.:.  ....|.|:       :|:       |..:|
Frog   281 VGLLDMTKEKE-----FFDVWPV-LMGEVPPYT--GPRTPDGREIVFYKVIDYILHGKEDIKVIP 337

  Fly   568 QPKEAPRGSLHS-----VRRCSF--DVRSIASDGLRRTSLAKLTSLPLEAPITKIINLLSQVQEN 625
            .| .|...:|.|     |....|  ::.:..:|     .:.|....||:.....:.|:||....|
Frog   338 NP-PADHWALVSGLPTYVAESGFICNIMNAGAD-----EMFKFQKEPLDESGWVVKNVLSMPIVN 396

  Fly   626 CSAD-------------------EARLIDKVLEFLKREGLYS---PQMKEIRTDDPIATDLIGAL 668
            ...:                   :..|::.:.:||....|.:   .:|.::.....||.|::
Frog   397 KKEEIVGVATFYNRKDGKPFDEQDETLMESLTQFLGWSVLNTDTHDKMNKLENRKDIAQDMV--- 458

  Fly   669 LTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLS----------WDFDIF 723
                 :|.. :...|.|         ..|:|.:.|....:.|..::.::          ..|:|:
Frog   459 -----MYHV-KCDKDEI---------QDILPTREKLGKEVTECEEDEIAKTLKQVLPGPTKFEIY 508

  Fly   724 KLEEITDYH----PLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADV 784
            :. ..:|:.    .|:..|::|:....|.....:.......::..::..||:. ||||..|..:|
Frog   509 EF-RFSDFDCTEIDLVKCGIQMYYELGVVKKFQVPPEALVRFMYAMKKGYRRV-TYHNWRHGFNV 571

  Fly   785 MQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLEN 849
            .|.  .|...:|.|.......:|....:.|...||:||.|.::.:...|...||.|:.. ::||.
Frog   572 AQT--MFTLLMTGKLKRYYTDLEAMAMVTAGFCHDIDHRGTNNLYQMKSQHPLAKLHGS-SILER 633

  Fly   850 HHAAITF-KLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRD 913
            ||  :.| |..|.|:.:|||:||::..::.....:...|:||::..:|:....|..:....:..:
Frog   634 HH--LEFGKFLLADESMNIFQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDQSKTYE 696

  Fly   914 HNPQTDEETSI------LMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQ--RHLP 970
            ...:..|..|:      ::..|::...|:|...:|.:...:.|..:|.|::.|.|.|:.  :..|
Frog   697 DEQKWTEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQQP 761

  Fly   971 IVMPMFDR-ATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQ-LITYMQINYSQWK----KYDEQG 1029
            |  ||.|| .:..:||.|.|||:::...:...:..|.:..| ::..:..|..:||    :| |..
Frog   762 I--PMMDRNKSAELPKLQCGFIDFVCTFVYKEFARFHEEIQPMLDGLLNNRKEWKALADEY-EAK 823

  Fly  1030 VNTLAEIMAKQ 1040
            |.|:.|...|:
Frog   824 VKTVEEEKKKR 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	15/103 (15%)
		PAS_9	463..539	CDD:290162	14/99 (14%)
		PDEase_I	775..1016	CDD:278654	64/251 (25%)
pde6b	XP_012808736.2	GAF	77..236	CDD:214500	32/166 (19%)
		GAF	258..445	CDD:214500	34/200 (17%)
		PDEase_I	562..806	CDD:365964	64/250 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920