Protein Alignment Pde8 and myh7b

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_031750297.1
• Gene: myh7b / 100486122
• XenbaseID: XB-GENE-6048377
• Length: 1942
• Species: Xenopus tropicalis
• Alignment Length: 904
• Identity: 175/904 - (19%)
• Similarity: 315/904 - (34%)
• Gaps: 225/904 - (24%)

  Fly   151 EEMELEYE------ANVEAESRDIMTPLRRNTRPLSVSFGGGGGRSALQPEIVEAIRSLDVPALR 209
            ||:|.|.|      |.||.:..::...|..    ||......||.:::|   :|..:..:...|:
 Frog  1124 EELEEELEAERATRAKVEKQRAEVAKELEE----LSERLEEAGGATSVQ---IEMNKKREAEFLK 1181

  Fly   210 LNNLSFDGSTDPKGERNHAEEEPLTPGHDHEDSVV-LRRKVNCLERKAHSLYERRLPRVPKLHLL 273
            |..       |.:....|.|.........|.|:|. |..:::.|:|....|
 Frog  1182 LRR-------DLEEATLHHEATAAGLRKKHADTVAELGEQIDSLQRVKQKL-------------- 1225

  Fly   274 VAGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQLDVTL 338
               :|.....:.|...|..|:..|.                  |:....|.:   |:.::..::.
 Frog  1226 ---EKEKSEMKMEIDDFTSNIEQLT------------------KNKGNAEKL---CRTYEDQLSE 1266

  Fly   339 VKSKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEK 403
            .|||   :|.||:..|....                 |.||.  .|....|:.::.       ||
 Frog  1267 AKSK---VDELQRQLADISL-----------------HRARL--QTENGELSRLLE-------EK 1302

  Fly   404 DDVLIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDD 468
            :.:        ||:......:......|||:.|....:..|.::  .||..:.|..        |
 Frog  1303 ESL--------VNQLSRGKASFTQTIEELKRQLEEETKAKNALA--HALQASRHDC--------D 1349

  Fly   469 LLRIQY-----ANRATERLLNMRLDEIISKQLEDIFVSDLSTISEQCKNIKEFDGILTVRRKSQE 528
            |:|.||     |....:|.|:....|:  .|..:.:.:|....:|:.:..|:   .|..|.:..|
 Frog  1350 LMREQYEEEQEAKGELQRSLSKANAEV--AQWRNKYETDAIQRTEELEEAKK---KLAARLQDAE 1409

  Fly   529 GIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASD 593
            ..   |.|....|.....|......::.    |.:..|.:...| ..:|...:| :||  .|..:
 Frog  1410 EA---VEVANAKCSSLEKTKHRLQTEIE----DLVIDLERANSA-AAALDKKQR-NFD--RILGE 1463

  Fly   594 GLRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDD 658
            ..::   .:.|...|||...:..:|.:::.:..:|.|..|.:  ||.:|||.      |.::.:.
 Frog  1464 WKQK---YEETQAELEASQKESRSLSTELFKLKNAYEESLDN--LETMKREN------KNLQEEI 1517

  Fly   659 PIATDLIGALLTGPSVYSSRR-----SSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSW 718
            ...||.|.|  :|..::...:     .|..|.|:........|:...:.|:..|.:||  ..:..
 Frog  1518 ADLTDQISA--SGKMIHELEKVKKALESEKSDIQAALEEAEGALEHEESKTLRIQLEL--SQIKA 1578

  Fly   719 DFD---IFKLEEITDYHPLLYLGME-MFRRFDVFA------------------TLNIDENVCKAW 761
            |.|   ..|.|||.:........|| |....|..|                  .:.|..|.....
 Frog  1579 DVDRKVAEKDEEIENLRRNHQRAMESMQASLDAEAKARNEAIRLKKKMEGDLNEMEIQLNHANRQ 1643

  Fly   762 LAV-------IEAHYRKSNTYHNST--HAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAA 817
            .|.       :::|.:......:.|  |..|:.:...|    |..::.|::..:||..|.:..|.
 Frog  1644 AAESQKMVRNLQSHIKDLQIELDDTLRHNDDLKEQAAA----LERRNNLLLAEVEELRAALEQAE 1704

  Fly   818 HDVDHPGRSSA--FLCNSNDALAVLYNDLTVLENH----HAAITFKLTLGDDKINIFKNLDKETY 876
            .     ||..|  .|..:.:.:.:|::..|.|.|.    .|.|:...|..::.:...:|.:::
 Frog  1705 R-----GRKLAEQELLEATERVNLLHSQNTGLINQKKKLDADISQLTTEVEESVQECRNAEEK-- 1762

  Fly   877 KSARSTIIDMILATE-------MTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMR------- 927
              |:..|.|..:..|       .|.|.|.:.|.:.    :..:|...:.||...|.::
 Frog  1763 --AKKAITDAAMMAEELKKEQDTTAHLERMKKNME----QTIKDLQMRLDEAEQIALKGGKKQIQ 1821

  Fly   928 RMLIKVADVSNP--------ARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDR 978
            ::..||.::...        |...:...::.||| :|...||:|:: ::|..:..:.|:
 Frog  1822 KLEAKVRELEGELEIEQKKNAETQKGVRKYERRI-KELTYQTEEDR-KNLARMQDLIDK 1878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	18/84 (21%)
		PAS_9	463..539	CDD:290162	18/80 (23%)
		PDEase_I	775..1016	CDD:278654	46/234 (20%)
myh7b	XP_031750297.1	Myosin_N	35..73	CDD:397036
		MYSc_Myh7b	100..774	CDD:276953
		Myosin_tail_1	854..1931	CDD:396244	175/904 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165172313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930