Protein Alignment Pde8 and pde10a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_031757888.1
• Gene: pde10a / 100485841
• XenbaseID: XB-GENE-1013417
• Length: 799
• Species: Xenopus tropicalis
• Alignment Length: 602
• Identity: 128/602 - (21%)
• Similarity: 217/602 - (36%)
• Gaps: 198/602 - (32%)

  Fly   576 SLHSVRRCSFDVRSIASDGLRRTSLAKLTSLP---LEAPITKIINLLSQVQENCSADEARLIDKV 637
            ::|.|:.|              ..|||.|.|.   |:...|...|:::             ||.:
 Frog   248 AIHQVQVC--------------RGLAKQTELNDFLLDVSKTYFDNIVA-------------IDSL 285

  Fly   638 LEFL--------------------KREGLYS---------------PQMKEIR--TDDPIATDL- 664
            ||.:                    |.:.|||               .:.||||  .:..||..:
 Frog   286 LEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEDEGKPVFKKTKEIRFSIEKGIAGQVA 350

  Fly   665 -IGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPI-IMELLD-------------- 713
             .|.:|..|..|:..|.:.:..:.||.:||....:|..::.:.| ::::::
 Frog   351 RTGEVLNIPDAYADPRFNREVDVYTGYTTRNILCMPIVIRGSVIGVVQMVNKLSGSAFSKTDENN 415

  Fly   714 --------------------------------ESLS---------WD------------------ 719
                                            |.||         |.
 Frog   416 FKMFAVFCALALHCANMYHRIRHSECIYRVTLEKLSYHSICTSDEWQNLMNCTLPVSLCREIELY 480

  Fly   720 -FDIFKLEEITDYHPLLYL-------GMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYH 776
             |||...|   |..|.:|:       |...|..          |.:|:..::| :.:||:. .||
 Frog   481 HFDIQPFE---DLWPAIYVYMIHQSCGKNCFEL----------EKLCRFTMSV-KKNYRRV-PYH 530

  Fly   777 NSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLY 841
            |..||..|...  .::....|::  :...:|....|:|...||:||.|.::::|...:..||.||
 Frog   531 NWKHAVTVSHC--MYVILQNNQE--IFTDLERKGLLVACLCHDLDHRGYTNSYLQKFDHPLAALY 591

  Fly   842 NDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMT------RHFEHLA 900
            :..| :|.||.:.|..: |..:..|||.||....|:.....|...|:||::.      :|.|.|.
 Frog   592 STST-MEQHHFSQTVSI-LQLEGHNIFSNLSSNEYEQVLEIIRKAIIATDLALYFGNRKHLEDLH 654

  Fly   901 KFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPAR--PMQFCIEWARRIAEEYFMQTDE 963
            :..::       :.|.|...:..|   .:::...|:.:..:  |:...|  |..|..|::.:.||
 Frog   655 QMGAL-------NLNNQAHRDRLI---GLMMTACDLCSVTKLWPVTRLI--ADDIYAEFWTEGDE 707

  Fly   964 EKQRHL-PIVMPMFDR-ATCSIPKSQIGFIEYI-IQDMMHAWESFIDMPQLITYMQINYSQWKKY 1025
            .|:..: ||  ||.|| ....||:.|:||...: :.......|.|.....|:...:.|.|||:|.
 Frog   708 MKRLGISPI--PMMDRDKQDEIPQGQMGFYNAVAVPCYTTLSEIFPSTRPLLQACKENLSQWEKV 770

  Fly  1026 DEQGVNTLAEIMAKQPP 1042
             .:|.:|...|.::..|
 Frog   771 -SRGEDTTVWIPSQSLP 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	65/251 (26%)
pde10a	XP_031757888.1	GAF	110..223	CDD:396252
		GAF	282..437	CDD:214500	25/154 (16%)
		PDEase_I	529..761	CDD:395177	65/251 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010