DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and pde6c

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_002937230.1	Gene:	pde6c / 100485634	XenbaseID:	XB-GENE-487059	Length:	853	Species:	Xenopus tropicalis

Alignment Length:	789	Identity:	165/789 - (20%)
Similarity:	293/789 - (37%)	Gaps:	198/789 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 TTIIAVCKKSFFEKDDV-----LIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVMSTQ 449
            |.:..|.|.|.||.:.|     ::..||.|:...||.|.. :....::|:..|     .:..:.:
Frog   111 TRLFNVTKSSKFEDNLVAPESEIVFPLDIGIVGWVAHTKK-SFNVPDVKKNTH-----FSDFADK 169

  Fly   450 QALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSDLSTISEQCK--- 511
            |..||..:.|...:|...::|.:..|       :|.:.....||:.|::|...|:.||...|
Frog   170 QTGYTTKNLLAAPILQGKEVLAVMMA-------VNKQNAAEFSKEDEEVFHKYLNFISVVLKYNH 227

  Fly   512 -----NI-------------KEFDGILTVRRKSQEGIPMHVRVV--------------------- 537
                 ||             |.|:.:..:.|:..:.: ..|||.
Frog   228 INYLHNIETRKSQVLLWTANKVFEELTDIERQFHKAL-YTVRVYLNCERYSVGLLDMTKEKEFYE 291

  Fly   538 --PVACIGSAPTHLIFNFDVPGGQ-------MDF-------IATLPQPKE-------------AP 573
              |:. :|..|.:.  ....|.|:       :|:       |..:|.|.|             |.
Frog   292 EWPIK-LGEVPPYK--GPKTPDGREVIFYKIIDYILHGKEEIKVIPTPPEDHWSLVSGLPTYVAE 353

  Fly   574 RGSLHSVRRC------SFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEAR 632
            .|.:.::...      .|...::...|   .::..:.|||:.....:|:.:.:.....    :|:
Frog   354 NGFICNMMNAPADEFFKFQKEAVDETG---WTIKNVLSLPIVNKKEEIVGVATFYNRK----DAK 411

  Fly   633 LIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSND-------------- 683
            ..|:          |..|:.|      ..|.::|..:.....|.......:
Frog   412 PFDE----------YDEQITE------ALTQILGWSVLNTDTYDKMNKLENRKDIAQEMLMYQLK 460

  Fly   684 -------SIIRTG----------SSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDY 731
                   ||::|.          ..|....|:..:: .:||..||.:    :.|....:.|
Frog   461 CTPKELQSILKTKEKLNKEVEECEETELLKILKEEL-PDPITAELYE----FHFSDLPVSE---- 516

  Fly   732 HPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLT 796
            |.|:..|:.:|...:......:...|...|:..:...|| ..||||..|..:|.|.  .|...:|
Frog   517 HDLIKSGIRLFFEINAVDKFKVPVEVLTKWMYTVRKGYR-DITYHNWRHGFNVGQT--MFTLLMT 578

  Fly   797 NK------DMLVMDRMEEATALIAAA-AHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAI 854
            .|      |:       ||.|::||| .||:||.|.::.:...|...||.|:.. ::||.||...
Frog   579 GKLKKYYSDL-------EAFAMVAAAFCHDIDHRGTNNLYQMKSQAPLAKLHGS-SILERHHLEF 635

  Fly   855 TFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQ-- 917
            : |..|.|:.||||:.|:|..:::........|:||::..:|:....|..:....|......:
Frog   636 S-KTLLQDESINIFQTLNKRQFENVIHLFEVAIIATDLALYFKKRTMFQKIVDTTEQMQSEDERI 699

  Fly   918 ----TDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQ--RHLPIVMPMF 976
                .|.....::..|::...|:|...:|.:...:.|..:|.|::.|.|.|:.  :..||  ||.
Frog   700 KYIICDPTKKEIIMAMMMTGCDLSAITKPWEVQSKVALMVANEFWEQGDLERTVLQQQPI--PMM 762

  Fly   977 DR-ATCSIPKSQIGFIEYIIQDMMHAWESF-IDMPQLITYMQINYSQWKK----YDEQGVNTLAE 1035
            || .:..:||.|:|||:::...:...:..| .::..:...:|.|..|||.    |:|: :..|.|
Frog   763 DRNKSDELPKLQVGFIDFVCTFVYKEFSRFHKEILPMYDGLQNNRVQWKSQADVYEEK-MKILDE 826

  Fly  1036 IMAKQPPVG 1044
            ...|:.|.|
Frog   827 QKKKEEPNG 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	21/123 (17%)
		PAS_9	463..539	CDD:290162	20/119 (17%)
		PDEase_I	775..1016	CDD:278654	68/257 (26%)
pde6c	XP_002937230.1	GAF	74..223	CDD:214500	30/124 (24%)
		GAF	255..442	CDD:214500	30/213 (14%)
		PDEase_I	559..804	CDD:365964	68/257 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010