Protein Alignment Pde8 and pde4c

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_004911040.1
• Gene: pde4c / 100380081
• XenbaseID: XB-GENE-1002336
• Length: 801
• Species: Xenopus tropicalis
• Alignment Length: 617
• Identity: 169/617 - (27%)
• Similarity: 266/617 - (43%)
• Gaps: 152/617 - (24%)

  Fly   552 NFDVPGGQMDFIATLPQPKEAPRGS--------LHSVRRCSFDVR----------------SIAS 592
            :|||..|...  ...|...:|..||        .||.||.||..|                ||||
 Frog    85 SFDVENGLSS--GRSPLESQASPGSGLVLQGNFPHSQRRESFLYRSDSDYDLSPKAMSRNSSIAS 147

  Fly   593 D----------------GLR--RTSLAKLTSLP---------------------LEAPITKI--- 615
            |                .||  |::.|.||.|.                     .|..:.|:
 Frog   148 DLHGEDMIVTPFAQVLASLRTVRSNFAMLTHLQDRVSNKRSSGSNQPSACKPNLSEDAVQKLAIE 212

  Fly   616 --------INLLSQVQENCSADE------ARLIDKVLEFL---KREG---------LYSPQMKEI 654
                    ::.|..:|...|..|      .|::::.|..|   .|.|         .:..:..|:
 Frog   213 TLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSETSRSGNQVSEYISSTFLDKQHEV 277

  Fly   655 RTDDPIA----------TDLIGA-LLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPII 708
            ....|::          :.:.|. .||..|.:     ||.||.|.|..|.         :..|:.
 Frog   278 EIPTPVSKEKDKKKRPMSQISGVKKLTHSSSF-----SNCSIPRFGVKTE---------QEVPLA 328

  Fly   709 MELLDESLS-WDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKS 772
            .|:  |::: |..||||:.|.:...||..:...:|:..|:..|.:|..:....::..:|.||...
 Frog   329 KEV--ENINKWGLDIFKVAEYSGNRPLTVIMYSIFQERDLLKTFHIPVDTFITYMMTLEDHYHSD 391

  Fly   773 NTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDAL 837
            ..|||:.|||||.|:|...::  |.....|...:|...|:.|:|.|||||||.|:.||.|:|..|
 Frog   392 VAYHNNIHAADVAQSTHVLLS--TPALEAVFTDLEIMAAIFASAIHDVDHPGVSNQFLINTNSEL 454

  Fly   838 AVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKF 902
            |::|||.:||||||.|:.||| |.::..:||:||.|:..::.|..:|||:|||:|::|...||..
 Frog   455 ALMYNDASVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMNLLADL 518

  Fly   903 VSVFGGEEPRDHNPQTDEETS------------ILMRRMLIKVADVSNPARPMQFCIEWARRIAE 955
            .::.          :|.:.||            |.:.:.::..||:|||.:|::...:|..||..
 Frog   519 KTMV----------ETKKVTSLGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLEIYRQWTDRIIV 573

  Fly   956 EYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFI--DMPQLITYMQIN 1018
            |:|.|.|.|:::.:.| .||.|:...|:.|||:|||:||:..:...|...:  |..:::..::.|
 Frog   574 EFFHQGDREREKGMEI-SPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDN 637

  Fly  1019 YSQWKKYDEQGVNTLAEIMAKQPPVGKMANSK 1050
            ...::....|..:...|  .:.|..|..|..|
 Frog   638 REWYQSMIPQSPSPPPE--EQDPDRGNAAGDK 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	93/254 (37%)
pde4c	XP_004911040.1	PDEase_I	394..635	CDD:278654	93/254 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920