Protein Alignment Pde8 and pde11a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_002934646.1
• Gene: pde11a / 100379882
• XenbaseID: XB-GENE-5999893
• Length: 892
• Species: Xenopus tropicalis
• Alignment Length: 1016
• Identity: 215/1016 - (21%)
• Similarity: 348/1016 - (34%)
• Gaps: 318/1016 - (31%)

  Fly   144 RNS-SKTPEEMELEYEANVEAESRDIMTPLRRNTRPLSVSFGGGGGRSALQPEIVEAI---RSLD 204
            ||. :|||.      .::.:.:|:|..:           :.|.|..|.|.|.|:.::.   ::::
 Frog    41 RNQLAKTPS------SSSADDKSKDCWS-----------NRGDGLQRRASQKELRKSFARSKAIN 88

  Fly   205 VPALRLNNLSFDGSTDPKGERNHAEEEPLTPGHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPK 269
            |      |.::|...      |...:||||.         :||:  .|.|||.||
 Frog    89 V------NRTYDEHV------NSRAQEPLTS---------MRRR--ALLRKASSL---------- 120

  Fly   270 LHLLVAGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKAL-LVFHKSDSICEAITAACQRHQ 333
                      |||..........:.:::       |..|..|: .:::..:.         ....
 Frog   121 ----------PPTTAHILSALLESRVNI-------PQYPSTAIDYIYYLKEH---------NERA 159

  Fly   334 LDVTLVKSKEEALDTLQKSYATAQCYHLII-----IDARSSKNLDAEHIARTIRHTHGHHLTTII 393
            ..:.|||.....|:      .|:.||.::|     :||........|..|.
 Frog   160 FFLELVKDISNELN------LTSLCYKILIFVCIMVDADRCSLFLVEGTAN-------------- 204

  Fly   394 AVCKKS----FFEKDDVLIALLDAGVNRCVAETTNLAMCSVELKQILH-----SIIRPHNVMSTQ 449
               |||    ||:        :.||       ||.|..||.|....:.     .||.
 Frog   205 ---KKSLVSKFFD--------VHAG-------TTLLPSCSTENSNEVQVPWGKGIIG-------- 243

  Fly   450 QALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSDLSTISEQCKNIK 514
               |.|.|  .|.|.|.|     .|.:|        |..:.|.|      ::...|.|..|..|:
 Frog   244 ---YVAEH--GETVNIPD-----AYQDR--------RFSDEIDK------LTGYKTKSLLCMPIR 284

  Fly   515 EFDGILTVRRKSQEGIPMHVRVVPVACIGSAP----------THLIF-NFDVPGGQMDFIATLPQ 568
            ..||.:.       |:...:...|    |.||          .:|.| ...:...|: |.|:
 Frog   285 SSDGEII-------GVAQAINKTP----GGAPFIEDDEKVMQMYLPFCGIAISNAQL-FAAS--- 334

  Fly   569 PKEAPRG-SLHSVRRCSFD--------VRSI---ASDGLRRTSLAKLTSLPLEAPITKIINLLSQ 621
            .||..|. :|..|....|:        |:.|   |.:.|:....:.|....:|:|:.|.......
 Frog   335 RKEYDRSRALLEVVNDLFEEQTDLEKVVKKIMHRAQNLLKCERCSVLLLEDIESPVVKFTKSFEL 399

  Fly   622 VQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALL--TGPSV-----YSSRR 679
            :...||||             .|..:...:::....|.:..:.|..|:  ||..|     |...|
 Frog   400 LSPKCSAD-------------TENSFKDSVEKSSYSDWLVNNSIAELVASTGLPVNISDAYQDPR 451

  Fly   680 SSNDSIIRTGSSTRTAAIVPAKMKSNPII-------------MELLDESL--------------- 716
            ...::...:|...|:...||....|:.||             .:..|:.|
 Frog   452 FDVEADQFSGFHIRSVLCVPIWNSSHQIIGVAQVLNRIDGKPFDDADQRLFEAFVIFCGLGINNT 516

  Fly   717 --------SW-------------------DFDIFKLE--------EITDYH---------PLLYL 737
                    ||                   :.|.||..        .|.|.|         .::..
 Frog   517 IMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELSIADIHFDDFCLDVDAMISA 581

  Fly   738 GMEMFRRFDVFATLNID-ENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDML 801
            .:.||....:.....|| |.:|: ||..|..:||.. .|||..||.:|.|...|.:|....::
 Frog   582 ALRMFMELGMVQKFKIDYETLCR-WLLTIRKNYRMV-LYHNWRHAFNVCQLMFAMLTTAGFQE-- 642

  Fly   802 VMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHH--AAITFKLTLGDDK 864
            |:...|....::....||:||.|.::||...|..||:.||.....||:||  .|:   :.|..:.
 Frog   643 VLSDTETLALIVGCLCHDLDHRGTNNAFQAKSGSALSQLYGTSATLEHHHFNHAV---MILQSEG 704

  Fly   865 INIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRM 929
            .|||.||..:.|......:...||||::|.|||...:|..:.   ...|:|... :...::.|.|
 Frog   705 HNIFANLSSQEYSDLMQLLKQSILATDITLHFERRNEFFELV---NKGDYNWNV-KSHRVIFRSM 765

  Fly   930 LIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDR-ATCSIPKSQIGFIEY 993
            |:...|:....:|.:...:.|..:..|:|.|.|.|:.........:||| ....:|:.|:.:|:.
 Frog   766 LMTACDLGAATKPWEISRQVAELVTSEFFEQGDRERLELKMTPSAIFDRNRKDELPRLQLEWIDN 830

  Fly   994 IIQDMMHAWESFI----DMPQLITYMQINYSQWKK-YDEQG 1029
            |...:   :||.:    .:..::..:..|..:|:: :.:||
 Frog   831 ICFPL---YESLVKINGKLKPMLDSVTTNRGKWEELHRKQG 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	16/79 (20%)
		PAS_9	463..539	CDD:290162	15/75 (20%)
		PDEase_I	775..1016	CDD:278654	66/247 (27%)
pde11a	XP_002934646.1	GAF	173..335	CDD:214500	51/246 (21%)
		GAF	357..523	CDD:214500	30/178 (17%)
		PDEase_I	618..853	CDD:365964	66/246 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010