Protein Alignment Pde8 and pde2a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_021322214.1
• Gene: pde2a / 100332468
• -ID: -
• Length: 851
• Species: Danio rerio
• Alignment Length: 921
• Identity: 196/921 - (21%)
• Similarity: 326/921 - (35%)
• Gaps: 264/921 - (28%)

  Fly   241 DSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAGKKNPPTEEEEFRTFQRNLMDLKYPTVLPP 305
            |:|..:|:|.|                        ...||    .|....||:       .:..|
Zfish     8 DAVQQQRRVQC------------------------SGLNP----AELHHTQRS-------ALTTP 37

  Fly   306 NPPLKALLVFHKSDS-----ICEAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLIIID 365
            .|.::.:::....|:     || .|..:|:      .|.:..|:.|..|:| :.|..|..:..:.
Zfish    38 LPAVRRVVIVPLVDADEGKVIC-LILLSCK------ALTEQDEQNLTVLEK-HLTVACKRVRNVQ 94

  Fly   366 ARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIAL------LDAG------VNRC 418
            ..||    |.|     ..:|...:....:.....:.|.|..::.|      |||.      :|..
Zfish    95 RFSS----APH-----AQSHNAPVEAKPSPPANDYRELDRKILQLCGELYDLDASSLQLKVINYL 150

  Fly   419 VAETTNLAMCSVELKQILHSI---IRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATE 480
            ..||.:...|.:.:.:..|.:   :....::..:.:......|..:|| .|...:.:|..::.|.
Zfish   151 QTETQSQCCCLLLVSEDNHQLFCQVVGDKILEEEISFPLMFGRFGQVV-ETKKSITLQDVSQVTH 214

  Fly   481 RLLNMRLDEIISKQLEDIFVSDLSTISEQCKNIKEFDGILTVRRKSQ-EGIPMHVRVVPVACIGS 544
            ...:|::.:::.                     .|.:.:|.|...|| .|     :||.:||
Zfish   215 THTHMQIQQLLG---------------------SEPNSMLCVPVVSQATG-----QVVALAC--- 250

  Fly   545 APTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKL------ 603
                   .|:..|||        :..||..   |.::.|.....::.:..|......||
Zfish   251 -------TFNKLGGQ--------RYMEADE---HVIQHCFCYTSTVLTSTLAFQKEQKLKFECQA 297

  Fly   604 --------------TSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKRE----GLYSPQ 650
                          .|:.|:..|.:..||.:  .|.||   ..|:|:|...|..:    |:.:..
Zfish   298 LLQVAKNLFTHLDDVSVLLQEIIVEARNLSN--AEICS---VFLLDRVSHELVAKVFDGGVVNDD 357

  Fly   651 MKEIR--TDDPIATDL--IGALLTGPSVYSS---RRSSNDSIIRTGSSTRTAAIVPAKMKSNPII 708
            .||.|  .|..||..:  .|.:|.....||.   .|..:||   ||..||.....|.|.::..:|
Zfish   358 EKEFRIPADQGIAGHVATTGKILNIKDAYSHPLFYRGVDDS---TGFRTRNILCFPIKDENEEVI 419

  Fly   709 --MEL-----------LDESLSWDFDIF----------------------KLEEITDYH------ 732
              .||           .||.|:..|.|:                      ...|:..||
Zfish   420 GVAELXNKTNGPWFNRFDEDLATAFSIYCGISIAHSLLYKRVHEAQFRSHLANEMMMYHMKVSEE 484

  Fly   733 ---PLLYLGME------------------------------MFRRFDVFATLNIDENVCKAWLAV 764
               .||.:|:|                              ||.......|..||.:....:..:
Zfish   485 EVSKLLTIGIESVQKIHANFAEFTYTPRSLPDDNTPMAVLSMFEDMGFINTYKIDLHTLARFCLM 549

  Fly   765 IEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATAL---IAAAAHDVDHPGRS 826
            ::..|| ...|||..||..|     :....|..|::.:.:.:::...|   ::...||:||.|.:
Zfish   550 VKKGYR-DPPYHNWMHAFSV-----SHFCYLLYKNLELSNYLQDIEILALFVSCMCHDLDHRGTN 608

  Fly   827 SAFLCNSNDALAVLY-NDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILAT 890
            ::|...|...||.|| ::.:|:|.||.|....: |.....|||:...::.|:.....:.|:||||
Zfish   609 NSFQVASQSVLAALYSSEGSVMERHHFAQAIAI-LNTHGCNIFEKFSRKDYQRMLDLMRDIILAT 672

  Fly   891 EMTRH---FEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARR 952
            ::..|   |:.|.|...|       ..||......|:|: .:|:...|:|:..:..:...:.|..
Zfish   673 DLAHHLRIFKDLQKMADV-------GFNPNNRTHRSLLL-CLLMTSCDLSDQTKGWKTTRKIAEL 729

  Fly   953 IAEEYFMQTDEEK-QRHLPIVMPMFDRATCSIPKSQIGFIEYI---IQDMMHAWESFIDMPQLIT 1013
            |.:|:|.|.|.|| ..:.|  ..|.||....||:.||.|:|:|   |..::.  |.|....:|..
Zfish   730 IYKEFFSQGDLEKAMGNRP--SEMMDREKAYIPELQISFMEHIAMPIYKLLQ--EIFPRSAELYE 790

  Fly  1014 YMQINYSQWKK 1024
            .:..|..||.|
Zfish   791 RVSANREQWAK 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	14/80 (18%)
		PAS_9	463..539	CDD:290162	13/76 (17%)
		PDEase_I	775..1016	CDD:278654	70/251 (28%)
pde2a	XP_021322214.1	GAF	138..289	CDD:214500	33/198 (17%)
		GAF	311..462	CDD:214500	40/158 (25%)
		PDEase_I	559..789	CDD:306695	69/247 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010