DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and pde7a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_005162725.1	Gene:	pde7a / 100151215	ZFINID:	ZDB-GENE-031222-10	Length:	516	Species:	Danio rerio

Alignment Length:	508	Identity:	128/508 - (25%)
Similarity:	221/508 - (43%)	Gaps:	109/508 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 KLTSLPLEAPITKII---------------------NLLSQVQENCSADEA-------RLIDKVL 638
            :|..|||:.|:.|.:                     ..|||.:...|.|.:       |::....
Zfish     6 QLPVLPLDRPVPKHVLSRRGAISFSSSSSLFGAPDPRQLSQRRGAISYDSSDQTALYIRMLAVTN 70

  Fly   639 EFLKREGLYSPQ----MKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSI---IRT-GSSTRTA 695
            :.:|...:::|.    .|::.:.|......:|       ....||.|:..:   .|| .|...:|
Zfish    71 KTIKSSFVFTPGACVIFKQLFSRDVRVRSQVG-------FEPERRGSHPYLGIDFRTLHSRAESA 128

  Fly   696 AIVPAK-----------------MKSNPII--MELLDESL------------SWDFDIFKLEEIT 729
            ..:||:                 ::..|.:  :.:|||..            ||:||||..:.:|
Zfish   129 GSIPARRIRRLFSFQRHLLSSRLLRGAPHLNPLHILDEDYCGQAKCMLEKVGSWNFDIFLFDRLT 193

  Fly   730 DYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQ 794
            :.:.|::|...:..::.:.....:|....:.:|.:::..|...|.|||:.|||||.||...::.:
Zfish   194 NGNSLVFLTFHLLSQYGLIELFQLDMVKVRRFLVLVQEDYHNQNPYHNAVHAADVTQAMHCYLRE 258

  Fly   795 ------LTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAA 853
                  ||:.|:|:        .|:|||.||:||||.:..||..:|..||.||.:.:||||||..
Zfish   259 PKLAQSLTSFDILL--------GLLAAATHDLDHPGVNQPFLIKTNHYLAALYRNTSVLENHHWR 315

  Fly   854 ITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQT 918
            ....|.   .:..:|.:|..|...|....:..:||||:::|..|:|::|         |.|..:.
Zfish   316 SAVGLL---RETELFSHLPAEDSLSIERQLGSLILATDISRQNEYLSRF---------RTHLDEN 368

  Fly   919 DEETSILMRR-----MLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDR 978
            |........|     |.:|.||:.||.||.:...:|:.::.||:|.|.|.||:..|.| .|:.|.
Zfish   369 DLNLGNASHRHFVLQMALKCADICNPCRPWELSKQWSEKVTEEFFHQGDIEKKLKLEI-SPLCDS 432

  Fly   979 ATCSIPKSQIGFIEYIIQDMMHAWESFID---MPQLITYMQINYSQWKKYDEQ 1028
            ...:|...||||:.|:::.:...|..|.|   ...::.::.:|.:.|...:.:
Zfish   433 EANTIASVQIGFMTYVVEPLFAEWARFSDTRLSQTMLGHLGLNKASWSTMEPE 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	83/254 (33%)
pde7a	XP_005162725.1	PDEase_I	239..459	CDD:278654	81/240 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589322
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850