DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and pde1a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_001096444.1	Gene:	pde1a / 100125056	XenbaseID:	XB-GENE-949176	Length:	538	Species:	Xenopus tropicalis

Alignment Length:	409	Identity:	119/409 - (29%)
Similarity:	198/409 - (48%)	Gaps:	44/409 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   608 LEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDD-PI-ATDLIGALLT 670
            ||.....:.:|.:.::...|..||..||:....|..|    .::.:|.||. |: ..|.:.:..|
Frog    42 LEKGDINVTDLKNNIEYAASVLEAVYIDETRRLLDTE----DELSDIHTDSVPLEVRDWLASTFT 102

  Fly   671 GPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKM---KSN--------PIIMELLDESLSWDFDIFK 724
            .......||.......|:......|.|...:|   .||        .:|..:.|.. .|.|::|.
Frog   103 RKMGMRKRRPEEKPKFRSIVHAVQAGIFVERMYRRSSNIAGLTYPSSVIASMKDVD-RWAFNVFT 166

  Fly   725 LEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRK-SNTYHNSTHAADVMQAT 788
            |.|.:..|.|.::..|:|.|:|:.....|..:...:::..:|..|.| .|.|||..|||||.|..
Frog   167 LNEASGEHALKFMVYELFTRYDLTNRFKIPVSNLVSFVEALEVGYSKYKNPYHNLVHAADVTQTV 231

  Fly   789 GAFITQ------LTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVL 847
            ...|..      ||..::|.|        :.|||.||.:|.|.::.|...:...:|:||||.:||
Frog   232 HYIILHTGIMHWLTELEILAM--------IFAAAIHDFEHTGTTNNFHIQTRSDVAILYNDRSVL 288

  Fly   848 ENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPR 912
            ||||.:..::: :.||::|||.||.|:.::..|:.:|:|:|:|:|:.||:.|....|..
Frog   289 ENHHVSAAYRI-MQDDEMNIFINLSKDDWRDLRTLVIEMVLSTDMSGHFQQLKTMRSTL------ 346

  Fly   913 DHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFD 977
             ..|:..::...:  .:::..||:|:||:|....:.|...:.||:|.|.|:|....||. .|:.|
Frog   347 -QQPEGIDKAKAM--SLILHAADISHPAKPWDMHLRWTNLLMEEFFRQGDKEAALGLPF-SPLCD 407

  Fly   978 RATCSIPKSQIGFIEYIIQ 996
            |.:..:.:||||||::|::
Frog   408 RKSTMVAQSQIGFIDFIVE 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	77/228 (34%)
pde1a	NP_001096444.1	PDEase_I_N	77..133	CDD:312112	12/59 (20%)
pde1a	NP_001096444.1	PDEase_I	218..446	CDD:306695	77/228 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010