Protein Alignment Pde8 and pde1b

DIOPT Version :10

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_017946519.1
• Gene: pde1b / 100036722
• XenbaseID: XB-GENE-987197
• Length: 554
• Species: Xenopus tropicalis
• Alignment Length: 587
• Identity: 145/587 - (24%)
• Similarity: 244/587 - (41%)
• Gaps: 114/587 - (19%)

  Fly   520 LTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCS 584
            |:..|:.|.|.|:             |.|                  |...|:|......:..|:
 Frog     3 LSTTRRLQRGTPL-------------PLH------------------PGMMESPSVDKDLLEGCT 36

  Fly   585 --FDVRSIASDGL--RRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREG 645
              |:::|..|..:  :..||.|.....||.....|:.|...::...|..||..||:..:.|..:
 Frog    37 SPFELKSAPSKKMWVKLRSLLKYMVKQLENGEVNIVELKKNLEYTASLLEAVYIDETRQILDTD- 100

  Fly   646 LYSPQMKEIRTDD--PIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKM------ 702
               .::.|:|:|.  ....|.:.:..|..:..:.|||......|:......|.|...:|
 Frog   101 ---DELPEMRSDSVPSEVRDWLASTFTQQTRSTGRRSEEKPRFRSIVHAVQAGIFVERMFRRSYT 162

  Fly   703 -----KSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWL 762
                 .|..::..|....| ||||:|.|..:::.|.|..:..|:..|.::.:...|......::|
 Frog   163 AVGPNYSAAVVNSLKHLDL-WDFDVFVLNRVSEDHALKTIVFELLSRHNLNSRFKIPVAFLMSFL 226

  Fly   763 AVIEAHYRK-SNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRS 826
            ..:|:.|.| .|.|||..|||||.|....|:  |....:..::.:|....:.|||.||.:|.|.:
 Frog   227 DSLESGYGKYKNPYHNQIHAADVTQTVHCFL--LRTGMVHCLNEIEILAIIFAAAIHDFEHTGTT 289

  Fly   827 SAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATE 891
            ::|...:....|:||||.:||||||.:..::: :.||::|||.||.|:.:...||.:|:|:|||:
 Frog   290 NSFHIQTKSDCAILYNDRSVLENHHVSAVYRI-MQDDEMNIFVNLTKDEFTELRSLVIEMVLATD 353

  Fly   892 MTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEE 956
            |:.||:.:....:..       ...:|.:::..|  .:|:..||:|:|.:..:....|.:.:.||
 Frog   354 MSCHFQQVKTMKTSL-------QQLETIDKSKAL--SLLLHAADISHPTKQWKVHARWTKALMEE 409

  Fly   957 YFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYI--------------------------- 994
            :|.|.|:|.:..||. .|:.||.:..:.:|||||||:|
 Frog   410 FFRQGDKEAEMGLPF-SPLCDRKSTLVAQSQIGFIEFIVDPTFSVLTDVAEKTVLPLVEERSKSK 473

  Fly   995 ----------------IQDMMHAWESFIDMPQLIT----YMQINYSQWKKYDEQGVNTLAEIMAK 1039
                            |.|.....:...|:....|    |:|.|..:||:....|:.....:...
 Frog   474 STASVNQSSSQWRQPSIDDHSEMGDINADIKSFRTTWTKYIQENKQKWKERAASGITNQTSVDEL 538

  Fly  1040 QP 1041
            .|
 Frog   539 SP 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	NtrB	446..>539	CDD:443061	5/18 (28%)
		PDEase_I	775..1016	CDD:459723	81/287 (28%)
pde1b	XP_017946519.1	PDEase_I_N	95..155	CDD:462497	12/63 (19%)
		PDEase_I	240..467	CDD:459723	76/239 (32%)