DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eglp4 and aqp4

DIOPT Version :9

Sequence 1:	NP_001261154.1	Gene:	Eglp4 / 37739	FlyBaseID:	FBgn0034885	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_001345242.1	Gene:	aqp4 / 445293	ZFINID:	ZDB-GENE-040724-152	Length:	346	Species:	Danio rerio

Alignment Length:	248	Identity:	83/248 - (33%)
Similarity:	124/248 - (50%)	Gaps:	11/248 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FKRFSDHFSCCK--VFKMKGS-TLDKISAFLGELIGTGILVFLGC-----MGCVKTDLFPNNHLQ 90
            |:|.....||..  :...||. |.:...|..||.:...|.|.|..     .|..:.:..|.:.:.
Zfish    10 FRRCVSSCSCNNSIMAAFKGVWTQEFWRAVSGEFLAMIIFVLLSLGSTINWGAKQENPPPADLVL 74

  Fly    91 IVLNFGFAVLIAIQCFGCVSGAHLNPAVTVAAYIYEMVTLRMAFAYFAAQMLGAFIGYGLLMVLL 155
            |.|.||.::...:||||.:||||:|||||||......::|.....|..||.|||.:|..:|..:.
Zfish    75 ISLCFGLSIATLVQCFGHISGAHINPAVTVAMVATRKLSLAKGVFYLLAQCLGAVVGAAILYGVT 139

  Fly   156 PSPTLTVGAGLCVTLPHTSVTTGQALGIEFVITSILVIVCCGVWDPRNSKFHDSVGIRFGLAIAC 220
            |:   :|..|:.||..:..::.|.|:.||.:||..||.......||:.:....|..:..||::..
Zfish   140 PA---SVRGGMGVTSVNEEISAGHAIVIELIITFELVFTVFATCDPKRNDLKGSAALAIGLSVCI 201

  Fly   221 LACAAGPFTGGSMNPARSFAPALWNKHFESNWIYWLAPLSSSAITAYAYKVVF 273
            ....|.|:||.||||||||.||:....::.:|:||:.||....:.|..|:.:|
Zfish   202 GHLFAIPYTGASMNPARSFGPAVIMVKWQDHWVYWVGPLIGGILAAAVYEYLF 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eglp4	NP_001261154.1	MIP	59..272	CDD:294134	75/217 (35%)
aqp4	NP_001345242.1	MIP	32..250	CDD:278651	75/220 (34%)
aqp4	NP_001345242.1	DUF737	<290..>345	CDD:310129
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850