DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eglp4 and AQP6

DIOPT Version :9

Sequence 1:	NP_001261154.1	Gene:	Eglp4 / 37739	FlyBaseID:	FBgn0034885	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_001643.2	Gene:	AQP6 / 363	HGNCID:	639	Length:	282	Species:	Homo sapiens

Alignment Length:	230	Identity:	76/230 - (33%)
Similarity:	117/230 - (50%)	Gaps:	13/230 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 CKVFKMKGSTLDKIS-AFLGELIGTGILVFLGCMGCVKTDLFPNNHLQIVLNFGFAVLIAIQCFG 107
            |:::|       .|| |...|.:.||:.||.|....::......:.|||.:.|.....:|:|...
Human    17 CRLWK-------AISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAITFNLVTAMAVQVTW 74

  Fly   108 CVSGAHLNPAVTVAAYIYEMVTLRMAFAYFAAQMLGAFIGYGLLMVLLPSPTLTVGAGLCVTLPH 172
            ..||||.|||||:|..:...::|..|.||.|||::||.:|..||..::|.   .:...|.:.:..
Human    75 KASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPG---DIRETLGINVVR 136

  Fly   173 TSVTTGQALGIEFVITSILVIVCCGVWDPRNSKFHDSVGIRFGLAIACLACAAGPFTGGSMNPAR 237
            .||:||||:.:|.::|..||:......|.|.:.  .|.....|:::|........|||.||||||
Human   137 NSVSTGQAVAVELLLTLQLVLCVFASTDSRQTS--GSPATMIGISVALGHLIGIHFTGCSMNPAR 199

  Fly   238 SFAPALWNKHFESNWIYWLAPLSSSAITAYAYKVV 272
            ||.||:....|..:|::|:.||..:.:.:..|..|
Human   200 SFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFV 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eglp4	NP_001261154.1	MIP	59..272	CDD:294134	71/212 (33%)
AQP6	NP_001643.2	MIP	25..231	CDD:294134	70/210 (33%)
		NPA 1	82..84		1/1 (100%)
		NPA 2	196..198		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..282
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2887
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.900