Protein Alignment Eglp4 and AQP4

DIOPT Version :9

• Sequence 1: NP_001261154.1
• Gene: Eglp4 / 37739
• FlyBaseID: FBgn0034885
• Length: 297
• Species: Drosophila melanogaster
• Sequence 2: NP_001304313.1
• Gene: AQP4 / 361
• HGNCID: 637
• Length: 352
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 93/309 - (30%)
• Similarity: 143/309 - (46%)
• Gaps: 49/309 - (15%)

  Fly    15 KRWTMA---CDREG-----SSLFSVALFKRFSDHFSCCKVFKMKGSTLDKISAFLGELIGTGILV 71
            :||...   |.||.     ..:::.|.:|..:..|....:|         :...||..|..|
Human     8 RRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIF---------VLLSLGSTINWG--- 60

  Fly    72 FLGCMGCVKTDLFPNNHLQIVLNFGFAVLIAIQCFGCVSGAHLNPAVTVAAYIYEMVTLRMAFAY 136
                 |..|.  .|.:.:.|.|.||.::...:||||.:||.|:|||||||......:::..:..|
Human    61 -----GTEKP--LPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFY 118

  Fly   137 FAAQMLGAFIGYGLLMVLLPSPTLTVGAGLCVTLPHTSVTTGQALGIEFVITSILVIVCCGVWDP 201
            .|||.|||.||.|:|.::.|.   :|..||.||:.|.::|.|..|.:|.:||..||.......|.
Human   119 IAAQCLGAIIGAGILYLVTPP---SVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS 180

  Fly   202 RNSKFHDSVGIRFGLAIACLACAAGPFTGGSMNPARSFAPALWNKHFESNWIYWLAPLSSSAITA 266
            :.:....|:.:..|.::|.....|..:||.||||||||.||:...::|::||||:.|:..:.:..
Human   181 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAG 245

  Fly   267 YAYKVV------FRREVVEA-------------EITSNEKLRQLEDVQL 296
            ..|:.|      |:|...||             |:..|....:.:|:.|
Human   246 GLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLIL 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eglp4	NP_001261154.1	MIP	59..272	CDD:294134	75/212 (35%)
AQP4	NP_001304313.1	MIP	31..248	CDD:278651	78/238 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140762
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850