DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eglp3 and Mip

DIOPT Version :9

Sequence 1:	NP_611812.2	Gene:	Eglp3 / 37738	FlyBaseID:	FBgn0034884	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_032626.2	Gene:	Mip / 17339	MGIID:	96990	Length:	263	Species:	Mus musculus

Alignment Length:	232	Identity:	78/232 - (33%)
Similarity:	118/232 - (50%)	Gaps:	20/232 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 WRLEGHQRSAI--ACFFGELAATAVFVFI---ACMGCVETPLFQNSH-FRSGLTFGLAILIAIQC 75
            |.|    |||.  ...|.|..||..:||.   |.:.....||    | .:..|.||||:...:|.
Mouse     2 WEL----RSASFWRAIFAEFFATLFYVFFGLGASLRWAPGPL----HVLQVALAFGLALATLVQT 58

  Fly    76 FGSVSGAHLNPAITLAAWLYGAIGWIRAIAYFVAQAAGALIGYGLLVAVLPGNSIKGVDNPSGVC 140
            .|.:||||:|||:|.|..:...:..:||..|..||..||:.|..:|.:|.| .:::|     .:.
Mouse    59 VGHISGAHVNPAVTFAFLVGSQMSLLRAFCYIAAQLLGAVAGAAVLYSVTP-PAVRG-----NLA 117

  Fly   141 VTILAPGISVLQGVFIEFLITCCLVMVACSVWDPRNAKLQDSVPVRFGLTVSCLILTAGLFTGAS 205
            :..|..|:||.|...:|..:|...|:...:.:|.|......||.:..|.:::...|....:|||.
Mouse   118 LNTLHAGVSVGQATTVEIFLTLQFVLCIFATYDERRNGRMGSVALAVGFSLTLGHLFGMYYTGAG 182

  Fly   206 MNPTRSLGPAVWNDSWAHHWIYWVGPLVAGAVTSLIY 242
            |||.||..||:...::::||:|||||::.|.:.||:|
Mouse   183 MNPARSFAPAILTRNFSNHWVYWVGPIIGGGLGSLLY 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eglp3	NP_611812.2	MIP	30..244	CDD:294134	73/217 (34%)
Mip	NP_032626.2	MIP	3..219	CDD:395174	76/229 (33%)
		Important for formation of cell junction. /evidence=ECO:0000250	34..38		0/3 (0%)
		NPA 1	68..70		1/1 (100%)
		NPA 2	184..186		1/1 (100%)
		Interaction with CALM. /evidence=ECO:0000250	227..237
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..263
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830767
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850