DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eglp3 and Aqp2

DIOPT Version :9

Sequence 1:	NP_611812.2	Gene:	Eglp3 / 37738	FlyBaseID:	FBgn0034884	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_033829.3	Gene:	Aqp2 / 11827	MGIID:	1096865	Length:	271	Species:	Mus musculus

Alignment Length:	247	Identity:	78/247 - (31%)
Similarity:	117/247 - (47%)	Gaps:	13/247 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 WRLE--GHQRSAIACFFGELAATAVFVFIACMGCVETPLFQNSHFRSGLTFGLAILIAIQCFGSV 79
            |.|.  ...|:.:|    |..||.:|||......::......|..:..:.|||.|...:|..|.|
Mouse     2 WELRSIAFSRAVLA----EFLATLLFVFFGLGSALQWASSPPSVLQIAVAFGLGIGTLVQALGHV 62

  Fly    80 SGAHLNPAITLAAWLYGAIGWIRAIAYFVAQAAGALIGYGLLVAVLPGNSIKGVDNPSGVCVTIL 144
            ||||:|||:|:|..:...:.::||..|..||..||:.|..:|..:.|      |:....:.|..|
Mouse    63 SGAHINPAVTVACLVGCHVSFLRAAFYVAAQLLGAVAGAAILHEITP------VEIRGDLAVNAL 121

  Fly   145 APGISVLQGVFIEFLITCCLVMVACSVWDPRNAKLQDSVPVRFGLTVSCLILTAGLFTGASMNPT 209
            ....:..|.|.:|..:|..||:...:..|.|.:....|..:..|.:|:...|....|||.||||.
Mouse   122 HNNATAGQAVTVELFLTMQLVLCIFASTDERRSDNLGSPALSIGFSVTLGHLLGIYFTGCSMNPA 186

  Fly   210 RSLGPAVWNDSWAHHWIYWVGPLVAGAVTSLIYR-MAFKGDEEIDLRTSDAK 260
            |||.|||....:..||::|:||||...:.||:|. :.|...:.:..|.:..|
Mouse   187 RSLAPAVVTGKFDDHWVFWIGPLVGAVIGSLLYNYLLFPSTKSLQERLAVLK 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eglp3	NP_611812.2	MIP	30..244	CDD:294134	71/214 (33%)
Aqp2	NP_033829.3	MIP	3..219	CDD:278651	73/225 (32%)
		NPA 1. /evidence=ECO:0000250\|UniProtKB:P41181	68..70		1/1 (100%)
		NPA 2. /evidence=ECO:0000250\|UniProtKB:P41181	184..186		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830732
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2356
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.880