DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eglp2 and AQP6

DIOPT Version :9

Sequence 1:	NP_788433.2	Gene:	Eglp2 / 37737	FlyBaseID:	FBgn0034883	Length:	290	Species:	Drosophila melanogaster
Sequence 2:	NP_001643.2	Gene:	AQP6 / 363	HGNCID:	639	Length:	282	Species:	Homo sapiens

Alignment Length:	248	Identity:	89/248 - (35%)
Similarity:	124/248 - (50%)	Gaps:	20/248 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 MSSEEPPSGKQTCRSQSNC--WLLQRRQLDSITTVLAEMIATAMLMFLGCMGSVEN-SVFTNSDF 78
            |.:.||  |.:...|...|  |....|.|      .||.:||.:.:|.| :|||.. .....|..
Human     1 MDAVEP--GGRGWASMLACRLWKAISRAL------FAEFLATGLYVFFG-VGSVMRWPTALPSVL 56

  Fly    79 QSALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMALAYFVAQMVGAFIGYGLLKAV 143
            |.|:.|..|..:.:|......|||.|||||||..|.:.||||.|:||..||:|||.:|..||..|
Human    57 QIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGV 121

  Fly   144 LPESAIYSAENPNGVCLTSLNSTLTPWQGLAVEFLITCVLISVCCGVWDPRNATKQDSLPVRFGL 208
            :|      .:....:.:..:.::::..|.:|||.|:|..|:.......|.|..:  .|.....|:
Human   122 MP------GDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTS--GSPATMIGI 178

  Fly   209 AIACLSLTAGQLTGASMNPVRSFAPAIWNGFWDDHWIYWVGPMAAALITSVIY 261
            ::|...|.....||.||||.|||.|||..|.:..||::||||:..||:.|:||
Human   179 SVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIY 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eglp2	NP_788433.2	MIP	41..261	CDD:294134	80/220 (36%)
AQP6	NP_001643.2	MIP	25..231	CDD:294134	80/220 (36%)
		NPA 1	82..84		1/1 (100%)
		NPA 2	196..198		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..282
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140801
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950