DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K59F and SH3PXD2A

DIOPT Version :9

Sequence 1:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_001380944.1 Gene:SH3PXD2A / 9644 HGNCID:23664 Length:1133 Species:Homo sapiens


Alignment Length:704 Identity:127/704 - (18%)
Similarity:237/704 - (33%) Gaps:230/704 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PDDHFRYI--------HSSSLHER------VQIKV---GTLEGKKRQPDYEKLLEDPILRFSGLY 51
            |..|:.||        .|.:::.|      :|:::   ..:||.::.|. ::::  |.|....|:
Human    20 PSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPK-QRII--PFLPGKILF 81

  Fly    52 SEEH----------PSFQ-----VRL--------QVFN--QGRPYCL-PVTSSYKAFGKRWSW-N 89
            ...|          |..:     |||        :||.  :.||..: |....|.:..::..| :
Human    82 RRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLS 146

  Fly    90 EWVTLP---LQFSDLPRSAMLVLTILDCSG-----AGQTTVIGGTSISMFGKD--GMFRQGMYDL 144
            .|...|   :..:|.....|::...:..|.     ..:.::..|..:.:..|:  |.:.....:.
Human   147 SWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEE 211

  Fly   145 RVWL---------GVEGDGNFPSRTPGKGKESSKSQMQRL-------GKLAKKHRNGQ----VQK 189
            :.|:         |...|.:..:...|:..:..|:.::||       |.:.::|...:    ||.
Human   212 QGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQP 276

  Fly   190 V--DWLDRLTFRE---IEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEG-------- 241
            .  ...|.:.|.:   :|||   .|.:..:.::.                 |...||        
Human   277 YTSQSKDEIGFEKGVTVEVI---RKNLEGWWYIR-----------------YLGKEGWAPASYLK 321

  Fly   242 DVKYKLPAKPKLVSVP----DSEIQMENLVERK--------------HHR-LARSERS------- 280
            ..|..||.:.|.::.|    .:.:::.||:.:|              |.. :|:.|.|       
Human   322 KAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNA 386

  Fly   281 ------GISDR------DAKPT----ASIRDQLHT--IVYRYPPT------YVLSSEEQDLVWKF 321
                  |:.||      ...|.    |..|.|:.:  :..|.||.      :.|....:....:.
Human   387 SNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEV 451

  Fly   322 RFYLSSHKKALTKFLKCIN--------WKLE--DEVTQALWML-----ANWAPMDVEDA-----L 366
            .:|      .:.:|..||:        .|.|  |:.:...|.:     ..|||....|.     |
Human   452 EYY------TIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNL 510

  Fly   367 ELLSPTFTHPQVRKYA--------------VSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLH 417
            ...:.|.|.|:|...|              .|....:|            :.||||:|.:.:...
Human   511 SRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSP------------RKLKYEEPEYDIPAF 563

  Fly   418 GCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVL---AAIKSDKSVSP 479
            | ...|.::....::|..|...:.:.....:.:|.|..:.....:.:..|.   ..|..::...|
Human   564 G-FDSEPELSEEPVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRP 627

  Fly   480 ---------GSAGGSGSGGQGSVALPNPSAP--ATPGSSS---LPCDSNSNALM 519
                     ||:|.|.|.|..|::|...::|  .:|.|||   |..:.|:.|.|
Human   628 YAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEM 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042 35/211 (17%)
PI3Ka_III 284..561 CDD:238442 61/305 (20%)
PI3Kc_III 601..945 CDD:270628
SH3PXD2ANP_001380944.1 PX_FISH 6..124 CDD:132798 20/106 (19%)
SH3_Tks5_1 170..222 CDD:213007 5/51 (10%)
SH3_Tks5_2 269..322 CDD:213010 11/72 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..446 6/30 (20%)
SH3_Tks5_3 451..504 CDD:213012 11/58 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 505..840 39/190 (21%)
SH3_Tks5_4 844..896 CDD:212952
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 899..924
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 941..964
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1029..1059
SH3_Tks5_5 1076..1132 CDD:212953
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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