Protein Alignment Pi3K59F and PIK1

DIOPT Version :9

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_014132.1
• Gene: PIK1 / 855454
• SGDID: S000005211
• Length: 1066
• Species: Saccharomyces cerevisiae
• Alignment Length: 935
• Identity: 195/935 - (20%)
• Similarity: 342/935 - (36%)
• Gaps: 244/935 - (26%)

  Fly   165 KESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDM 229
            |::|:|:     :::....:.....:|.:|.:..:|     :...|.|.:..:.::|.  :|||:
Yeast   218 KKTSRSK-----RVSSNRSSTPTSPIDLIDPIKTKE-----DASFRKSRHSEVKLDFD--IVDDI 270

  Fly   230 YNYAVVYFEPEGDVKYKLP-AKPKLV-------SVPDSEIQMENLVERKHHRL------------ 274
            .|..   ||.......||| .|||.:       :.....|..:..:......|
Yeast   271 GNQV---FEERISSSIKLPKRKPKYLDNSYVHRTYDGKNINRDGSISNTAKALDGNKGDYISPKG 332

  Fly   275 ----------ARSERSGISDRDAKP------TASIRDQLHTIVYRYPPTYVLSSEEQDLVWKF-- 321
                      ...|..|.::.||..      |:|:.| ||.|   .|.|...||...:...|.
Yeast   333 RNDENNEIGNNEDETGGETEEDADALNSDHFTSSMPD-LHNI---QPRTSSASSASLEGTPKLNR 393

  Fly   322 -------RFYLSSHKKALTKFLKCINWKLEDEV-------TQALWML-ANWAPMDVE--DALELL 369
                   |....:.|||        |..|..|:       |..:.|| ||:...:.:  .|||.:
Yeast   394 TNSQPLSRQAFKNSKKA--------NSSLSQEIDLSQLSTTSKIKMLKANYFRCETQFAIALETI 450

  Fly   370 SPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDN 434
            |             .|||:.|.|..|       .||:.|          .....||:...:  |.
Yeast   451 S-------------QRLARVPTEARL-------SALRAE----------LFLLNRDLPAEV--DI 483

  Fly   435 GSLLDQSSLSDLS--ATSSGLHGSVIPANQRAASVLAA--IKSDKSVSPGSAGGSG-----SGGQ 490
            .:||..:....|.  .|.:.....|:.:.::...:|..  ::.:....|.|.....     ||.|
Yeast   484 PTLLPPNKKGKLHKLVTITANEAQVLNSAEKVPYLLLIEYLRDEFDFDPTSETNERLLKKISGNQ 548

  Fly   491 GSVALP-------------NPSAPATPGSSSLPCDSNS--NALMLAEGISFGSVPANLCTFLIQR 540
            |.:...             |.|...:..:.|...||||  |.....||:|..|           |
Yeast   549 GGLIFDLNYMNRKENNENRNESTLTSNNTRSSVYDSNSFNNGASRNEGLSSTS-----------R 602

  Fly   541 ACTNATLANYFYWYLSIEVEEVESV---------RKQDERAHDMYAMVLKMFLKV---------- 586
            :.:.:|.      ::..||.:.|.:         .:.|:.|: ..|:|::....|
Yeast   603 SDSASTA------HVRTEVNKEEDLGDMSMVKVRNRTDDEAY-RNALVIQSAANVPILPDDSQDR 660

  Fly   587 --------------LENGNFNLRGIFYN---LRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQK 634
                          :||| .|.:.|...   |..|.|.  ..|.|.:| .|.|...::.|::.:.
Yeast   661 SPELNFGSNLDEVLIENG-INSKNIHSQTDALADQMRV--SAVMLAQL-DKSPQQLSESTKQIRA 721

  Fly   635 LLAE-----QDMFKVNFTNFEPI-----PFPLDPEIYITKIVPMRTSLFKS--ALMPAKLTFVTS 687
            .:..     ||.|  .:.:.|.:     ...|:.::....|   .||....  |....::...:.
Yeast   722 QIISSMKEVQDKF--GYHDLEALHGMAGERKLENDLMTGGI---DTSYLGEDWATKKERIRKTSE 781

  Fly   688 IAHHE----YAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVD 748
            ..|.|    .:.|.|.||||||:....|||..|..:..:|.:|:.:...|:|.||:..|.::.:.
Yeast   782 YGHFENWDLCSVIAKTGDDLRQEAFAYQMIQAMANIWVKEKVDVWVKRMKILITSANTGLVETIT 846

  Fly   749 SC----TVAEVLAR----------EGNI----HNFFRKHHPCDNGPYGIS-AEVMDTYIKSCAGY 794
            :.    ::.:.|.:          :|.|    .:|.|..    ..|.|.. ....|.:..|.|.|
Yeast   847 NAMSVHSIKKALTKKMIEDAELDDKGGIASLNDHFLRAF----GNPNGFKYRRAQDNFASSLAAY 907

  Fly   795 CVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPM---PPPMKLSKEMVEAMGGISSEH 856
            .||.|||.|.|||..|:::...|.:.|||||::|...|..:   ..|.||:.|.:|.:||:..|.
Yeast   908 SVICYLLQVKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGSVGFEAAPFKLTYEYIELLGGVEGEA 972

  Fly   857 HHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHL 921
            ..:|.:...:::..||::|:.::::..:|....:.......::...::.:..||.|:::|....:
Yeast   973 FKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQLDLSEKEVDDFV 1037

  Fly   922 QS-LLDVSITAVMPALVEQIHRFTQ 945
            :: |:..|:.::...:.:|....||
Yeast  1038 ENFLIGKSLGSIYTRIYDQFQLITQ 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	3/20 (15%)
		PI3Ka_III	284..561	CDD:238442	69/325 (21%)
		PI3Kc_III	601..945	CDD:270628	88/382 (23%)
PIK1	NP_014132.1	TEL1	<1..1066	CDD:227365	195/935 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810