DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and TOR2

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_012719.2	Gene:	TOR2 / 853632	SGDID:	S000001686	Length:	2474	Species:	Saccharomyces cerevisiae

Alignment Length:	1219	Identity:	240/1219 - (19%)
Similarity:	397/1219 - (32%)	Gaps:	425/1219 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QPDYEKLLEDPILRFSGLYSEEHPS--FQVRLQVF----NQGRPYCLPVTSSYK------AFGKR 85
            |..|::.|...:.:  .|.|.|:|.  :|:.|.:.    :..:|..:|:.:..|      ||.|.
Yeast  1290 QTSYQEDLIQALCK--ALSSSENPPEIYQMLLNLVEFMEHDDKPLPIPIHTLGKYAQKCHAFAKA 1352

  Fly    86 WSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQT-TVIGGTSISMFGKDGMFRQGMYD-LRVWL 148
            ..:.|     ::|.:.|:::.:...|...:...|| :.||....:....:...::..|: |:.|.
Yeast  1353 LHYKE-----VEFLEEPKNSTIEALISINNQLHQTDSAIGILKHAQQHNELQLKETWYEKLQRWE 1412

  Fly   149 GVEGDGNFPSRTPGKGKESSKSQM------------QRLGKLAKKH---RNGQVQKV-------- 190
            ......|   .....|::|.:..|            :.|.|||.:.   ...:|:|.
Yeast  1413 DALAAYN---EKEAAGEDSVEVMMGKLRSLYALGEWEELSKLASEKWGTAKPEVKKAMAPLAAGA 1474

  Fly   191 -----DW-------------------------LDRLTFR--EIEVINEREKRMSDYMFLMIEFPA 223
                 .|                         |.|..|:  |:.:.|.|:       .|:.|..|
Yeast  1475 AWGLEQWDEIAQYTSVMKSQSPDKEFYDAILCLHRNNFKKAEVHIFNARD-------LLVTELSA 1532

  Fly   224 IVVDDMYNYAV-------VYFEPEGDVKYK----------------------------------- 246
            : |::.||.|.       :..|.|..:|||
Yeast  1533 L-VNESYNRAYNVVVRAQIIAELEEIIKYKKLPQNSDKRLTMRETWNTRLLGCQKNIDVWQRILR 1596

  Fly   247 ---LPAKPKLVSVPDSEIQME--NLVERKHHRLARSER--------------------------- 279
               |..|||    .|::::::  ||. ||..|:|.:::
Yeast  1597 VRSLVIKPK----EDAQVRIKFANLC-RKSGRMALAKKVLNTLLEETDDPDHPNTAKASPPVVYA 1656

  Fly   280 -------SGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTK-FL 336
                   :|:.|...|...:...::...:...|...:..|..|... :...::..:.|.|.: ||
Yeast  1657 QLKYLWATGLQDEALKQLINFTSRMAHDLGLDPNNMIAQSVPQQSK-RVPRHVEDYTKLLARCFL 1720

  Fly   337 KCINWKLEDEVTQALWMLA------------------------NWAPMDVEDALELLSPTFTHPQ 377
            |...|::   ..|..|.|:                        |||..:.| .:.:|:......|
Yeast  1721 KQGEWRV---CLQPKWRLSNPDSILGSYLLATHFDNTWYKAWHNWALANFE-VISMLTSVSKKKQ 1781

  Fly   378 VRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPE-RDVVRSI-LDDNGSLLDQ 440
            ....| |.:....:.|..:..:....|.:.....:::|.|  :.|. :....|| |.::.||.|.
Yeast  1782 EGSDA-SSVTDINEFDNGMIGVNTFDAKEVHYSSNLIHRH--VIPAIKGFFHSISLSESSSLQDA 1843

  Fly   441 SSLSDLSATSSGLHGS------------------VIP--------ANQRAASVLAAIKSDKSVSP 479
            ..|..|..|..|:..:                  |:|        .||..:..|.::.||.
Yeast  1844 LRLLTLWFTFGGIPEATQAMHEGFNLIQIGTWLEVLPQLISRIHQPNQIVSRSLLSLLSDL---- 1904

  Fly   480 GSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSN---ALMLAEGISFGSVPANLCTFLIQRA 541
            |.|              :|.|...|...::..:|.|.   ||.:.|.:...|........|:...
Yeast  1905 GKA--------------HPQALVYPLMVAIKSESLSRQKAALSIIEKMRIHSPVLVDQAELVSHE 1955

  Fly   542 CTNATLANYFYWYLSIEVEEVESVRKQ---DERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRK 603
            .....:..:..||     |.::...:|   :.....|:| .|:...::|:.|...||.|.:....
Yeast  1956 LIRMAVLWHEQWY-----EGLDDASRQFFGEHNTEKMFA-ALEPLYEMLKRGPETLREISFQNSF 2014

  Fly   604 QRRFIDELVKLVKL-VAKEPGNRNK-------------------KTEKFQ----KLLAEQDMFK- 643
            .|...|....|:.. .:|:..|.|:                   :|.:.|    |||:..|:..
Yeast  2015 GRDLNDAYEWLMNYKKSKDVSNLNQAWDIYYNVFRKIGKQLPQLQTLELQHVSPKLLSAHDLELA 2079

  Fly   644 ------------VNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAI 696
                        |..:.|||:                 .|:..|...|.|.....|.. .:|..:
Yeast  2080 VPGTRASGGKPIVKISKFEPV-----------------FSVISSKQRPRKFCIKGSDG-KDYKYV 2126

  Fly   697 FKHGDDLRQDQLILQMITLMDKLLR------RENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEV 755
            .|..:|:|||.|::|:..|::.||:      |.:||::  .|..:..|.|.|.|.:|.:.....|
Yeast  2127 LKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQ--QYPAIPLSPKSGLLGWVPNSDTFHV 2189

  Fly   756 LAREGNIHNFFRKHHPCDNGPYGISAEVM------------------------------------ 784
            |.||         |......|..|...||
Yeast  2190 LIRE---------HREAKKIPLNIEHWVMLQMAPDYDNLTLLQKVEVFTYALNNTEGQDLYKVLW 2245

  Fly   785 -------------DTYIKSCAGYCVITYLLGVGDRHLDNLLL-TTNGKLFHIDFG-----YILGR 830
                         .||.:|.|...:..|:||:||||..||:| ...||:.|||||     .|| |
Yeast  2246 LKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAIL-R 2309

  Fly   831 DPKPMPPPMKLSKEMVEAM--GGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDI 893
            :..|...|.:|::.:..||  .||..    .||..|......||.      |..|||  |.:...
Yeast  2310 EKFPEKVPFRLTRMLTYAMEVSGIEG----SFRITCENVMKVLRD------NKGSLM--AILEAF 2362

  Fly   894 ALEP------DKAVKKVEE--NLQL-----------GLTDEEAVQHLQS 923
            |.:|      |...||:||  .:||           |...||.||.:::
Yeast  2363 AFDPLINWGFDLPTKKIEEETGIQLPVMNANELLSNGAITEEEVQRVEN 2411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	34/181 (19%)
		PI3Ka_III	284..561	CDD:238442	58/332 (17%)
		PI3Kc_III	601..945	CDD:270628	105/442 (24%)
TOR2	NP_012719.2	TEL1	290..2474	CDD:227365	240/1219 (20%)
		HEAT repeat	599..620	CDD:293787
		HEAT repeat	642..667	CDD:293787
		HEAT repeat	677..707	CDD:293787
		HEAT repeat	715..748	CDD:293787
		HEAT repeat	758..787	CDD:293787
		HEAT repeat	801..828	CDD:293787
		HEAT repeat	843..873	CDD:293787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900