DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K59F and TOR1

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_012600.1	Gene:	TOR1 / 853529	SGDID:	S000003827	Length:	2470	Species:	Saccharomyces cerevisiae

Alignment Length:	746	Identity:	157/746 - (21%)
Similarity:	247/746 - (33%)	Gaps:	281/746 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 EVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDP 410
            ||:||::...|.  |.:|:.||:|      ||:    :||:.| ||..:...||.|:..|....|
Yeast  1855 EVSQAMYEGFNL--MKIENWLEVL------PQL----ISRIHQ-PDPTVSNSLLSLLSDLGKAHP 1906

  Fly   411 RHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDK 475
            :.:|:                                                  .:..||||:
Yeast  1907 QALVY--------------------------------------------------PLTVAIKSE- 1920

  Fly   476 SVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGS-VPANLCTFLIQ 539
            |||...|                                  ||.:.|.|...| |..|... |:.
Yeast  1921 SVSRQKA----------------------------------ALSIIEKIRIHSPVLVNQAE-LVS 1950

  Fly   540 RACTNATLANYFYWYLSIE--------------------------------VEEVESVRKQDERA 572
            .......:..:..||..:|                                :.||...:......
Yeast  1951 HELIRVAVLWHELWYEGLEDASRQFFVEHNIEKMFSTLEPLHKHLGNEPQTLSEVSFQKSFGRDL 2015

  Fly   573 HDMYAMVLKMFLKVLENGNFNLR-GIFYNL-RKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKL 635
            :|.|.. |..:.|..:..|.|.. .|:||: ||..|.|.:| :.:.|....|           :|
Yeast  2016 NDAYEW-LNNYKKSKDINNLNQAWDIYYNVFRKITRQIPQL-QTLDLQHVSP-----------QL 2067

  Fly   636 LAEQDMFKVNFTNFEPIP---FPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIF 697
            ||..|:...       :|   ||..|.|.|.|..|: .|:..|...|.|.:...|.. .:|..:.
Yeast  2068 LATHDLELA-------VPGTYFPGKPTIRIAKFEPL-FSVISSKQRPRKFSIKGSDG-KDYKYVL 2123

  Fly   698 KHGDDLRQDQLILQMITLMDKLLR------RENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVL 756
            |..:|:|||.|::|:..|::.||:      :.:||::  .|..:..|.|.|.|.:|.:.....||
Yeast  2124 KGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQ--QYPAIPLSPKSGLLGWVPNSDTFHVL 2186

  Fly   757 AREGNIHNFFRKHHPCDNGPYGISAEVM------------------------------------- 784
            .||         |......|..|...||
Yeast  2187 IRE---------HRDAKKIPLNIEHWVMLQMAPDYENLTLLQKIEVFTYALDNTKGQDLYKILWL 2242

  Fly   785 ------------DTYIKSCAGYCVITYLLGVGDRHLDNLLL-TTNGKLFHIDFG-----YILGRD 831
                        .||.:|.|...:..|:||:||||..||:| ...||:.|||||     .|| |:
Yeast  2243 KSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAIL-RE 2306

  Fly   832 PKPMPPPMKLSKEMVEAM--GGISSEHHHEFRKQCYTAYLHLRRHAN---VMLNLFSL------- 884
            ..|...|.:|::.:..||  .||..    .||..|......||.:..   .:|..|:|
Yeast  2307 KYPEKVPFRLTRMLTYAMEVSGIEG----SFRITCENVMRVLRDNKESLMAILEAFALDPLIHWG 2367

  Fly   885 -------MVDAT-VPDIALEPDKAVKK----VEENLQLGLTDEEAVQHLQSLL------------ 925
                   :.:.| :|...:.|.:.::|    |||...:....:...::.:::|
Yeast  2368 FDLPPQKLTEQTGIPLPLINPSELLRKGAITVEEAANMEAEQQNETKNARAMLVLRRITDKLTGN 2432

  Fly   926 ------DVSITAVMPALVEQ---IHRFTQYW 947
                  ::.:...:..|::|   |.|..|::
Yeast  2433 DIKRFNELDVPEQVDKLIQQATSIERLCQHY 2463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042
		PI3Ka_III	284..561	CDD:238442	42/247 (17%)
		PI3Kc_III	601..945	CDD:270628	103/453 (23%)
TOR1	NP_012600.1	TEL1	279..2470	CDD:227365	157/746 (21%)
		HEAT repeat	588..620	CDD:293787
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..778	CDD:293787
		HEAT_EZ	771..820	CDD:290247
		HEAT repeat	792..827	CDD:293787
		DUF3385	827..986	CDD:288698
		Rapamycin_bind	1952..2049	CDD:285924	16/97 (16%)
		PIKKc_TOR	2090..2366	CDD:270713	75/293 (26%)
		FATC	2439..2470	CDD:280430	5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900