DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K59F and MEC1

DIOPT Version :9

Sequence 1:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_009694.3 Gene:MEC1 / 852433 SGDID:S000000340 Length:2368 Species:Saccharomyces cerevisiae


Alignment Length:991 Identity:186/991 - (18%)
Similarity:358/991 - (36%) Gaps:276/991 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 QFSDLPRSAMLVLTILDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTP 161
            :|||.|::...:|                             :.|||.:::..:..:.:|.|   
Yeast  1488 KFSDDPKTTTRML-----------------------------KSMYDHQLYSQIISNSSFHS--- 1520

  Fly   162 GKGKESSKSQMQRLGKLAKKHRN--GQVQKV-DWLDRLTFREIEVINEREKRMSDYMFLMIEFPA 223
            ..||.|....::....:..:..|  |.||.: :|::::  ..:..|::||..:            
Yeast  1521 SDGKISLSPDVKEWYSIGLEAANLEGNVQTLKNWVEQI--ESLRNIDDREVLL------------ 1571

  Fly   224 IVVDDMYNYAVVYF-----EPEGDVKY-----KLPAKPKLVSVPDSE-IQMENLVERKHHRLARS 277
                 .||.|....     :|....||     :|.....:.|..::. ::.:||:.:.|.....|
Yeast  1572 -----QYNIAKALIAISNEDPLRTQKYIHNSFRLIGTNFITSSKETTLLKKQNLLMKLHSLYDLS 1631

  Fly   278 ERSGISDR-DAKPTASIRD-QLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCIN 340
            ..|...|: :.|...:|.| ::..|...:.|.:               |:.|.:|:..: || :|
Yeast  1632 FLSSAKDKFEYKSNTTILDYRMERIGADFVPNH---------------YILSMRKSFDQ-LK-MN 1679

  Fly   341 WKLEDEVTQALWMLANWAPMDVEDALELLSPTFTH------PQVRKYAVSRLAQAPDEDLLLYLL 399
            .:.:.::.:..:.||..|..:..  |::.|.:..|      ||........|.:..:.|..|.::
Yeast  1680 EQADADLGKTFFTLAQLARNNAR--LDIASESLMHCLERRLPQAELEFAEILWKQGENDRALKIV 1742

  Fly   400 QLVQALKYEDPRHIVHLHGCIFPERDVVRSILD-------DNGSLLDQ-----------SSLSDL 446
            |.:.. ||::...:        ..||....:|.       .|.|..:|           .|..|.
Yeast  1743 QEIHE-KYQENSSV--------NARDRAAVLLKFTEWLDLSNNSASEQIIKQYQDIFQIDSKWDK 1798

  Fly   447 SATSSGLHGSVIPANQRAAS---------------VLAAIKSDKSVSPG----------SAGGSG 486
            ...|.||:.|.:...::|..               :||..|:...|...          .|..|.
Yeast  1799 PYYSIGLYYSRLLERKKAEGYITNGRFEYRAISYFLLAFEKNTAKVRENLPKVITFWLDIAAASI 1863

  Fly   487 SGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATL---- 547
            |...|     |.....:..:..: |.....||.......:..|...|.:.|:....::|.:    
Yeast  1864 SEAPG-----NRKEMLSKATEDI-CSHVEEALQHCPTYIWYFVLTQLLSRLLHSHQSSAQIIMHI 1922

  Fly   548 --------ANYFYWYLSIEVEE------------VESVRKQDERAHDMYAMVLKMFLKVLENGNF 592
                    .::..||::..|..            :|..|:..:..||:.:..|.: .|.|..   
Yeast  1923 LLSLAVEYPSHILWYITALVNSNSSKRVLRGKHILEKYRQHSQNPHDLVSSALDL-TKALTR--- 1983

  Fly   593 NLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDM---FKVNFTNFEPIPF 654
                             ..::.||.:....|...:|..||...:|...|   .:.|.....|:..
Yeast  1984 -----------------VCLQDVKSITSRSGKSLEKDFKFDMNVAPSAMVVPVRKNLDIISPLES 2031

  Fly   655 -------PLDPEIYITKIVPMRTS--LFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLIL 710
                   |..|   :..|:...:|  :|.|...|.:|..:.|.. :.|..:.|. :|:|||...:
Yeast  2032 NSMRGYQPFRP---VVSIIRFGSSYKVFSSLKKPKQLNIIGSDG-NIYGIMCKK-EDVRQDNQYM 2091

  Fly   711 QMITLMDKLL------RRENLDLKLTPYKVLATSSKHGFLQYVDS-CTVAEVLARE--------- 759
            |..|.||.||      |:.:|.:.:  |.||:.....|.|:.|.: .|:..:|:.:         
Yeast  2092 QFATTMDFLLSKDIASRKRSLGINI--YSVLSLREDCGILEMVPNVVTLRSILSTKYESLKIKYS 2154

  Fly   760 -GNIHNFFRKHHPCDNGPYGISAEVMD-------------------------TYIKSCAGYCVIT 798
             .::|:  |..|...:|......|.:|                         ||.:|.|...::.
Yeast  2155 LKSLHD--RWQHTAVDGKLEFYMEQVDKFPPILYQWFLENFPDPINWFNARNTYARSYAVMAMVG 2217

  Fly   799 YLLGVGDRHLDNLLL-TTNGKLFHIDFGYILGRDPK-PMPP--PMKLSKEMVEAMGGISSEHHHE 859
            ::||:||||.:|:|| ...||:.|:||..:..:..: |:|.  |.:|:..:::|:|.|.:|  ..
Yeast  2218 HILGLGDRHCENILLDIQTGKVLHVDFDCLFEKGKRLPVPEIVPFRLTPNLLDALGIIGTE--GT 2280

  Fly   860 FRKQCYTAYLHLRRHANVMLNLF-SLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQS 923
            |:|........:|::...::|:. ::|.|..: |.:::  ||:|.:...:: |:..::.      
Yeast  2281 FKKSSEVTLALMRKNEVALMNVIETIMYDRNM-DHSIQ--KALKVLRNKIR-GIDPQDG------ 2335

  Fly   924 LLDVSITAVMPALVEQ 939
             |.:|:......|:::
Yeast  2336 -LVLSVAGQTETLIQE 2350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042 14/90 (16%)
PI3Ka_III 284..561 CDD:238442 58/339 (17%)
PI3Kc_III 601..945 CDD:270628 87/398 (22%)
MEC1NP_009694.3 TEL1 194..2368 CDD:227365 186/991 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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