DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and VPS34

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_176251.1	Gene:	VPS34 / 842344	AraportID:	AT1G60490	Length:	814	Species:	Arabidopsis thaliana

Alignment Length:	959	Identity:	350/959 - (36%)
Similarity:	515/959 - (53%)	Gaps:	164/959 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DHFRYIHSSSLHERVQIKVGTLEGK---KRQPDYEKLLEDPILRFSGLYS---EEHPSFQVRLQV 64
            :.||:..|..::..|..::..|:|.   |:..|            ||:.|   |:.|...:...:
plant     4 NEFRFFLSCDINSPVTFRIEKLDGNLPVKKSSD------------SGVVSIAEEKKPELYIECAL 56

  Fly    65 FNQGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTVIGGTSIS 129
            :..|.|:.||:.:..|..|..:.|||.:||..::.||...:.|.:|:.|.|......:|||.::.
plant    57 YIDGAPFGLPMRTRLKTTGPPYCWNELITLSSKYRDLTAHSQLAITVWDVSCGKTEGLIGGATVL 121

  Fly   130 MFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLD 194
            :|......:.|...||:|.|.|.||:||:.||||.....:.:::||.||..|:..||:|.:||||
plant   122 LFNSKMQMKSGKQKLRLWQGKEADGSFPTSTPGKVPRHERGELERLEKLMNKYERGQIQSIDWLD 186

  Fly   195 RLTFREIEVINERE--KRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLP--AKPKLVS 255
            ||..:.::.|.|:|  |..|.::|::|:|.:      :.:.||:.|...::....|  :..:.|:
plant   187 RLMLKSLDTIKEQESTKHGSSHLFVVIDFCS------FEHRVVFQESGANLFITAPIGSTNEFVT 245

  Fly   256 VPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWK 320
            |.|:|:...|..|.|..:||||...||.|||.||:...|..:..:: :||||..||.:|:.|:||
plant   246 VWDTELGKTNPSENKQLKLARSLDRGIIDRDLKPSNIERKSIQRVL-KYPPTRTLSGDERQLLWK 309

  Fly   321 FRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSR 385
            |||.|.|.|:||||||:|:.|....|..||:.::..|..:||.||||||||.|...:||.||||.
plant   310 FRFSLMSEKRALTKFLRCVEWSDVQEAKQAIQLMYKWEMIDVCDALELLSPLFESEEVRAYAVSV 374

  Fly   386 LAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATS 450
            |.:|.||:|..|||||||||::|
plant   375 LERADDEELQCYLLQLVQALRFE------------------------------------------ 397

  Fly   451 SGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNS 515
                                 :||:|                                  |
plant   398 ---------------------RSDRS----------------------------------C---- 403

  Fly   516 NALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVL 580
                             |..||:|||..|..||::..||:::|:.:    ....:|.:..|.::.
plant   404 -----------------LSQFLVQRALQNIELASFLRWYVAVELHD----HVYAKRFYSTYELLE 447

  Fly   581 KMFLKVLE--NGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQK----LLAEQ 639
            :..:|:..  ||....: ::.:|.:|.....:|..:.:.|....||..||.||.::    ||:|.
plant   448 ENIIKLPPGVNGEDGYQ-LWQSLVRQTELTAQLCSITREVRNVRGNTQKKIEKLRQLLGGLLSEL 511

  Fly   640 DMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLR 704
            ..|:      |||..||.|.:.|..||...:|||||||.|.:|||.|.........|||.|||||
plant   512 TYFE------EPIRSPLTPNVLIKGIVAGESSLFKSALHPLRLTFRTPEEGGSCKLIFKKGDDLR 570

  Fly   705 QDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIHNFFRKH 769
            ||||::||:.|||:||:.|||||.|||||||||....|.|:::.|.::|::|:...:|.::.:|.
plant   571 QDQLVVQMVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHRSITSYLQKF 635

  Fly   770 HPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKP 834
            ||.::.|:||:|..:||:|||||||.||||:||:|||||||||||.:|:|||:||.:||||||||
plant   636 HPDEHAPFGITATCLDTFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDFAFILGRDPKP 700

  Fly   835 MPPPMKLSKEMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDK 899
            .||||||.|||||||||..|:::..|:..|..||..||:.:|::||||.||..:|:||||.:|:|
plant   701 FPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFHLMAGSTIPDIASDPEK 765

  Fly   900 AVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWR 948
            .:.|::|..:|.:.||..:...|.|::.|::|:.|.:||.|||:.||||
plant   766 GILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRWAQYWR 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	49/164 (30%)
		PI3Ka_III	284..561	CDD:238442	82/276 (30%)
		PI3Kc_III	601..945	CDD:270628	172/347 (50%)
VPS34	NP_176251.1	C2_PI3K_class_III	25..178	CDD:176042	49/164 (30%)
		PI3Ka_III	274..432	CDD:238442	82/276 (30%)
		PI3Kc_III	466..811	CDD:270628	172/350 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	182	1.000	Domainoid score	I1025
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1986
Inparanoid	1	1.050	636	1.000	Inparanoid score	I190
OMA	1	1.010	-	-		QHG54334
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0005021
OrthoInspector	1	1.000	-	-		oto3962
orthoMCL	1	0.900	-	-		OOG6_101850
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3549
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840