DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and TRRAP

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001362453.1	Gene:	TRRAP / 8295	HGNCID:	12347	Length:	3873	Species:	Homo sapiens

Alignment Length:	1218	Identity:	227/1218 - (18%)
Similarity:	372/1218 - (30%)	Gaps:	446/1218 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DPILRFSGLYSEEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSD------ 100
            :|:::|    ...|||..|.|        :.:..|.:..      .|:......|:..|
Human  1563 EPLIKF----LTRHPSQTVEL--------FMMEATLNDP------QWSRMFMSFLKHKDARPLRD 1609

  Fly   101 -LPRSAMLVLTILDCSGAGQTTV-IGGTSISMFGKDGMFRQGMYDLRV-------WLGVEGDGNF 156
             |..:....:|:| ..|..||.| .|..|.|....|..| |.:..:.:       ||.
Human  1610 VLAANPNRFITLL-LPGGAQTAVRPGSPSTSTMRLDLQF-QAIKIISIIVKNDDSWLA------- 1665

  Fly   157 PSRTPGKGKESSKSQMQRL---GKLAKKHRNGQVQKVDWLD------------RLTFREIEVINE 206
                   .:.|..||::|:   ....::||...:...:|.:            :..:.:||::.:
Human  1666 -------SQHSLVSQLRRVWVSENFQERHRKENMAATNWKEPKLLAYCLLNYCKRNYGDIELLFQ 1723

  Fly   207 REKR-----------MSDYM-----------------FLMIEF---------PAIVVDDMYNYAV 234
            ..:.           :.:||                 |..::|         .|.|:..:.|.|.
Human  1724 LLRAFTGRFLCNMTFLKEYMEEEIPKNYSIAQKRALFFRFVDFNDPNFGDELKAKVLQHILNPAF 1788

  Fly   235 VY-FE------------PEGDVKYKLPAKPK------LVSVPDSEIQMEN--------------L 266
            :| ||            ||||       .|:      :..|.|.|.|.:.              |
Human  1789 LYSFEKGEGEQLLGPPNPEGD-------NPESITSVFITKVLDPEKQADMLDSLRIYLLQYATLL 1846

  Fly   267 VERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYL------ 325
            ||...|.        |.|.:....:.:|   ..:.:.:|  .:||....|...|:..:|
Human  1847 VEHAPHH--------IHDNNKNRNSKLR---RLMTFAWP--CLLSKACVDPACKYSGHLLLAHII 1898

  Fly   326 ---SSHKKALTK----FLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAV 383
               :.|||.:.:    .||....:....|.||:.:|....|..:||..::|    || ..||..|
Human  1899 AKFAIHKKIVLQVFHSLLKAHAMEARAIVRQAMAILTPAVPARMEDGHQML----TH-WTRKIIV 1958

  Fly   384 SRLAQAPDEDLLLYLLQL-VQALK-YEDPRHIVHLHGCIFPER----------------DVVRSI 430
            ......|.   |:::|.| ||..| |...||.:..|.....:|                |:...:
Human  1959 EEGHTVPQ---LVHILHLIVQHFKVYYPVRHHLVQHMVSAMQRLGFTPSVTIEQRRLAVDLSEVV 2020

  Fly   431 LD-DNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVA 494
            :. :...:.||...||:...|||         :...||.::||...||.............|:::
Human  2021 IKWELQRIKDQQPDSDMDPNSSG---------EGVNSVSSSIKRGLSVDSAQEVKRFRTATGAIS 2076

  Fly   495 LPNPSAPATPGSSSL--------------------PCDSNSNA---------------------- 517
            .....:.:.||:.||                    .|..|.|.
Human  2077 AVFGRSQSLPGADSLLAKPIDKQHTDTVVNFLIRVACQVNDNTNTAGSPGEVLSRRCVNLLKTAL 2141

  Fly   518 ------------------LMLAE---GISFGSV----------------PANLCTFL-IQR---- 540
                              ||..|   .:::|::                ||.|.:|. :||
Human  2142 RPDMWPKSELKLQWFDKLLMTVEQPNQVNYGNICTGLEVLSFLLTVLQSPAILSSFKPLQRGIAA 2206

  Fly   541 --ACTNATLANYFYWYLS--IEVEEVE----SVRKQDERAHDMYAMVLKMFLKVLEN----GNFN 593
              .|.|..:....:..||  :.:...|    ||..:.|....:||.|.|:..:.|.|    .|.|
Human  2207 CMTCGNTKVLRAVHSLLSRLMSIFPTEPSTSSVASKYEELECLYAAVGKVIYEGLTNYEKATNAN 2271

  Fly   594 LRGIFYNL-------RKQRRFIDELV-----KLVKLVAK--EPGNRNKKTE-------------- 630
            ...:|..|       .....:||.|:     .|.|:|.:  .|...:..||
Human  2272 PSQLFGTLMILKSACSNNPSYIDRLISVFMRSLQKMVREHLNPQAASGSTEATSGTSELVMLSLE 2336

  Fly   631 --KFQKLLAEQDMFKVNFTN------FEPIPFPLDPEIY--ITKIV--------PMR-----TSL 672
              |.:..:...:|.| ||..      .|..|   |.:|.  :.|||        ||.     |..
Human  2337 LVKTRLAVMSMEMRK-NFIQAILTSLIEKSP---DAKILRAVVKIVEEWVKNNSPMAANQTPTLR 2397

  Fly   673 FKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMITLM--DKLLRRENLDLKLTPYKVL 735
            .||.|:...:|::..          :..:||..:...|.::..:  |:.|....|..||.|
Human  2398 EKSILLVKMMTYIEK----------RFPEDLELNAQFLDLVNYVYRDETLSGSELTAKLEP---- 2448

  Fly   736 ATSSKHGFLQYVDSCTVAEVLAREGNIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYL 800
                     .::.....|:.|.|.    .||               ||.|..:|.
Human  2449 ---------AFLSGLRCAQPLIRA----KFF---------------EVFDNSMKR---------- 2475

  Fly   801 LGVGDRHLDNLLLTT-------NGKLFHID--FGYILGRDPKPMPPPMKLSKEMVEAMGG-ISSE 855
                 |..:.||..|       .|..|.|.  ...:|....|..|........|:.::.. |:..
Human  2476 -----RVYERLLYVTCSQNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPSITNVINLA 2535

  Fly   856 HHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEP--------DKAVKKVEENLQLGL 912
            ..|:  :..:....|:::......|..|...|..: ||.|.|        .|.:.:.:...||.:
Human  2536 DSHD--RAAFAMVTHVKQEPRERENSESKEEDVEI-DIELAPGDQTSTPKTKELSEKDIGNQLHM 2597

  Fly   913 TDEEAVQHLQSLLDVSITAVMPALVEQIH------------RFTQYWR 948
            ......:.|.:|.:|...|::.|.|:..|            .|.:.|:
Human  2598 LTNRHDKFLDTLREVKTGALLSAFVQLCHISTTLAEKTWVQLFPRLWK 2645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	32/161 (20%)
		PI3Ka_III	284..561	CDD:238442	74/396 (19%)
		PI3Kc_III	601..945	CDD:270628	79/426 (19%)
TRRAP	NP_001362453.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..541
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:12138177	2017..2395		72/390 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2030..2051		9/29 (31%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	2054..2069		3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2550..2585		7/35 (20%)
		TEL1	<2552..3873	CDD:227365	19/95 (20%)
		FAT	2868..3200	CDD:367004
		PIKK_TRRAP	3510..3797	CDD:270707
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900