DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and Pi4kb

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_038959158.1	Gene:	Pi4kb / 81747	RGDID:	621214	Length:	862	Species:	Rattus norvegicus

Alignment Length:	806	Identity:	159/806 - (19%)
Similarity:	286/806 - (35%)	Gaps:	231/806 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 PPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLANWAP--MDVEDALE 367
            |||.:  .||:|         ......::...|....:.::...:..|:|..:..  .|:..|:.
  Rat   118 PPTEI--REEED---------EMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAIS 171

  Fly   368 LLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYED-------PRHIVHLHGCIFPERD 425
            .|..: ..|.|:.|..:||....:||:..||.||:....:.|       ..:|||
  Rat   172 YLYNS-KEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVH---------- 225

  Fly   426 VVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDK-----------SVSP 479
              |.....|.||  |.:|. |.|.||.:|.|. ..:.|...:...|.||:           ::||
  Rat   226 --RCRQSINFSL--QCALL-LGAYSSDMHIST-QRHSRGTKLRKLILSDELKPAHRKRELPTLSP 284

  Fly   480 GSAGG----------SGSGGQGSVAL--------PNPSAPATPGSSSLPCDSNSNAL-------- 518
            ....|          |.|....|::|        .||.........|...:|..|:.
  Rat   285 APDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAP 349

  Fly   519 -------MLAEGISFGSVPANLCTFLIQRACTNATLANY----FYW-------YLSIEVEEVESV 565
                   ::|.|....::|..  ....||..:..:|.|:    ..|       :..:.|...::|
  Rat   350 EREFIKSLMAIGKRLATLPTK--EQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAV 412

  Fly   566 --RKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKK 628
              ..:|:..:.:|       ::|||..||:...:                    .|:.|.||.:.
  Rat   413 VLNSKDKAPYLIY-------VEVLECENFDTTNV--------------------PARIPENRIRS 450

  Fly   629 TEKFQKLLAEQDMFKVNFTNFEPIP--------FPLD---------PEIY--------------I 662
            |...:.|.......:....:|..:|        :.:|         ||::              |
  Rat   451 TRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSI 515

  Fly   663 TKIVPMRTSLFKSALMPAKLTFVTSIAHHEYA--------------------------------- 694
            |...........:..:..:|:  ..:||...|
  Rat   516 TSQESKEPVFIAAGDIRRRLS--EQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHL 578

  Fly   695 -------AIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTV 752
                   .|.|.||||||:.|..|::..:..:..:|.:.|.:.|||:|..|:..|.::.|.:...
  Rat   579 PNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVS 643

  Fly   753 AEVLAREGNIH--NFFRKHHPCDNGPYGISA--EVMDTYIKSCAGYCVITYLLGVGDRHLDNLLL 813
            ...:.::..:.  ::|.:.|    |.|...|  .....:::||||||::.|||.|.|||..|:||
  Rat   644 IHQVKKQSQLSLLDYFLQEH----GSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILL 704

  Fly   814 TTNGKLFHIDFGYILGRDPKPM---PPPMKLSKEMVEAMGGISSEHHHEFRKQCYTAYLHLRRHA 875
            ...|.:.|||||:||...|:.:   ....||:.|.|:.|||::.:..:.::.......:..|:|.
  Rat   705 DAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHM 769

  Fly   876 NVMLNLFSLMVD--------------ATVPDI------ALEPDKAVKKVEENLQLGLTDEEAVQH 920
            :.::.:..:|..              .||..:      .......::.::|...:.:|:|:
  Rat   770 DKVVQIVEIMQQGCRRCSGASLSGPVVTVAQVICSQLPCFHGSSTIRNLKERFHMSMTEEQ---- 830

  Fly   921 LQSLLDVSITAVMPALVEQIHRFTQY 946
            ||.|::..:...|.::..:::...||
  Rat   831 LQLLVEQMVDGSMRSITTKLYDGFQY 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042
		PI3Ka_III	284..561	CDD:238442	64/319 (20%)
		PI3Kc_III	601..945	CDD:270628	85/441 (19%)
Pi4kb	XP_038959158.1	PI4KB_NTD	27..91	CDD:412074
Pi4kb	XP_038959158.1	PI4Kc_III_beta	554..862	CDD:270712	70/311 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900