DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K59F and pi4kab

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001106813.1	Gene:	pi4kab / 793349	ZFINID:	ZDB-GENE-080220-34	Length:	1099	Species:	Danio rerio

Alignment Length:	478	Identity:	106/478 - (22%)
Similarity:	158/478 - (33%)	Gaps:	146/478 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   526 FGSVPANLCTFLI-QRACTNATLANYFY---WYL----SIEVEEVESVRKQDERAHDMYAMVLKM 582
            |...|:.|...:| |..|...|...|.|   |.|    |::...|.....:|.:.|. |......
Zfish   588 FCQPPSPLDVLIIDQLGCMIITGNQYIYQEVWNLFQQISVKASNVVYSATKDYKDHG-YRHCSLA 651

  Fly   583 FLKVLENGNFNLRGIFYNLRKQRRFIDE-LVKLVKLVAK--EPGNR--NKKTEKFQKLLAEQDMF 642
            .:..|.|...||:|        ...:|| ||.|::|..:  ..|.|  .:.::|...|.|.....
Zfish   652 VINALANIAANLQG--------EPLVDELLVNLLELFVQLGLEGKRACERASDKGPALKASSSAG 708

  Fly   643 KVNFTNFEPIPF------PLDPEIYITKIVPMRTSLFK---------------SALMPAK-LTFV 685
            .:...    ||.      .|.|   |.:..|....||:               |.|.|.: ...|
Zfish   709 NLGVL----IPVIAVLTRRLPP---IKEAKPRLQKLFRDFWLYSVVMGFAVEGSGLWPEEWYEGV 766

  Fly   686 TSIAHHEYAAIFKHGDDLRQDQLILQMITLM--DKLLRRENLDLKLTPYKVLATSSK-HGFLQYV 747
            ..||.......|..|:.||.:   ||..:.:  |.:...|..||:.|...:|..|.: ...:..:
Zfish   767 CEIATKSPLLTFPSGEPLRSE---LQYNSALKNDTVTPAELSDLRSTIINLLDPSPEAAALINKL 828

  Fly   748 D--SCT-VAEVLAREGNIHNFFRKHHPCDNGPYGISAEVMDTYI--------KSCAGYCVITYLL 801
            |  .|| :..|...|     :.|..|..|...:    :||..|.        ||....|||.
Zfish   829 DFAMCTYLLSVYRLE-----YMRMLHSNDADRF----QVMFRYFEDKAIQKDKSGMMQCVIC--- 881

  Fly   802 GVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKEMVEAMGGISSEHHHEFRKQCYT 866
             |||            |:|.: |..::...||                   :.||..|
Zfish   882 -VGD------------KVFEV-FLQMMAEKPK-------------------TKEHEEE------- 906

  Fly   867 AYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQH-------LQSL 924
                |.|||..:|..|:            ...|.:::|.:....||.  |...|       |:::
Zfish   907 ----LERHAQFLLVNFN------------HTHKRIRRVADKYLSGLA--ETFPHLLWSGRVLKTM 953

  Fly   925 LDVSITAVMPALVEQIHRFTQYW 947
            ||:..|..: :|...||:...|:
Zfish   954 LDILQTLSL-SLSADIHKDQPYY 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042
		PI3Ka_III	284..561	CDD:238442	12/42 (29%)
		PI3Kc_III	601..945	CDD:270628	84/391 (21%)
pi4kab	NP_001106813.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900