Protein Alignment Pi3K59F and zgc:158659

DIOPT Version :10

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_001417769.1
• Gene: zgc:158659 / 791141
• ZFINID: ZDB-GENE-070112-492
• Length: 1070
• Species: Danio rerio
• Alignment Length: 916
• Identity: 218/916 - (23%)
• Similarity: 361/916 - (39%)
• Gaps: 289/916 - (31%)

  Fly    60 VRLQVFNQGRPYCLPV-TSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTV- 122
            ||..:::.|.|.|..| |........|  ||||::..:..:|:||||.|.|:|  ||..|:...
Zfish   358 VRTGIYHGGEPLCDNVNTQRVPCSNPR--WNEWLSYDIYLTDVPRSARLCLSI--CSVKGRKGAK 418

  Fly   123 -----IGGTSISMFGKDGMFRQGMYDLRVW------------LGVEGDGNFPSRTPGKGKESSKS 170
                 :...:|::|........|...|.:|            :||.| .|....||
Zfish   419 EEHCPLAWGNINLFDYKDTLVSGKVALGLWPVPHGLEDLLNPIGVSG-SNPNKETP--------- 473

  Fly   171 QMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVV 235
                                                         .:.:|||      .:|..||
Zfish   474 ---------------------------------------------CVELEFP------WFNQTVV 487

  Fly   236 YFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLAR----SERSGISDR---DAKPTASI 293
            :                    || |.|:|   |..:..::|    |...|:|.|   |:..:.:.
Zfish   488 F--------------------PD-EQQIE---EHANWSISRELGYSYCLGLSSRLACDSSISQAD 528

  Fly   294 RDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLANWA 358
            .:||.|:..| .|.|.||.:|:|.:|:.|.|..:..::|.|.|..:.|...|||:|...:|.:|.
Zfish   529 AEQLRTLCSR-DPLYELSEQEKDFLWRHRHYCVNIPESLPKLLLSVKWNSRDEVSQIYCLLKDWP 592

  Fly   359 PMDVEDALELLSPTFTHPQVRKYAVSRLAQA-PDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFP 422
            .|..|.:||||...|..|.||::|:..|.|. .|:.|..|||||||.||||
Zfish   593 LMQPESSLELLDCNFPDPMVREFALRCLIQGLTDDKLSQYLLQLVQVLKYE-------------- 643

  Fly   423 ERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGS 487
                                                                             
Zfish   644 ----------------------------------------------------------------- 643

  Fly   488 GGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFY 552
                 :.|.||                                  |..|||::|.||..:.::|:
Zfish   644 -----MYLDNP----------------------------------LARFLIKKALTNQRIGHFFF 669

  Fly   553 WYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFY-NLRKQRRFIDELVKLVK 616
            |:|..|:......|:        :.::|:.|.:..        |::. :|.:|...:|:||.|..
Zfish   670 WHLKSEMHNKTVSRR--------FGLLLEAFCRAC--------GMYLKHLNRQVEAMDKLVNLTD 718

  Fly   617 LVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTN-FEPIPFPLDPEIYITKIVPMRTSLFKSALMPA 680
            .:.:|..:..:||:  .|.|.|. |.:.::.. .:....||:|...:..:......:..||..|.
Zfish   719 TLKQEKKDETQKTQ--MKFLVEH-MSRPDYMEALQGFVSPLNPVHQLGNLRLEECRIMSSAKRPL 780

  Fly   681 KLTF-----VTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSK 740
            .|.:     ::.:.......|||:|||||||.|.||:|.:|:.:.:.:.|||::.||..|:....
Zfish   781 WLNWENPDIMSELLFTNNEIIFKNGDDLRQDMLTLQIIKIMENIWQNQGLDLRMLPYGCLSIGDC 845

  Fly   741 HGFLQYV-DSCTVAEVLAREG----------NIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGY 794
            .|.::.| :|.|:.::..:.|          .:|::.|     |..........:|.:.:|||||
Zfish   846 VGLIEVVKNSHTIMQIQCKGGLKGALQFNSNTLHHWIR-----DRNKGEAYDRAIDLFTRSCAGY 905

  Fly   795 CVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPM-----PPPMKLSKE-MVEAMGGI- 852
            ||.|::||:||||..|:::..||:|||||||:.|....|..     ..|..|::: ::....|:
Zfish   906 CVATFILGIGDRHNSNIMVKENGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGVQ 970

  Fly   853 ---SSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTD 914
               .::....|::.||.|||.:|:||::.:|||||::...:|::....|  :..:.:.|.|..:.
Zfish   971 ECTKTKEFERFQEMCYKAYLAIRQHASLFINLFSLLLGCGMPELQSFDD--IAYLRKTLALEKSQ 1033

  Fly   915 EEAVQH 920
            :||:::
Zfish  1034 QEALEY 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	34/144 (24%)
		PI3Ka_III	284..561	CDD:238442	65/280 (23%)
		PI3Kc_III	601..945	CDD:270628	99/347 (29%)
zgc:158659	NP_001417769.1	PI3K_p85B	34..107	CDD:460483
		PI3K_rbd	173..292	CDD:413336
		C2_PI3K_class_I_alpha	327..486	CDD:176043	38/192 (20%)
		PI3Ka_I	528..697	CDD:238444	66/303 (22%)
		Protein Kinases, catalytic domain	696..1065	CDD:473864	100/362 (28%)