Protein Alignment Pi3K59F and pik3cb

DIOPT Version :10

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_001072928.1
• Gene: pik3cb / 780390
• XenbaseID: XB-GENE-482674
• Length: 1065
• Species: Xenopus tropicalis
• Alignment Length: 988
• Identity: 237/988 - (23%)
• Similarity: 382/988 - (38%)
• Gaps: 315/988 - (31%)

  Fly    14 SSLHERVQIKVGTLEGKKR-----------------QPDYEKLLEDPILRFSGLYSEEHPSFQVR 61
            ||:|..:.:   .|..|||                 || |:.:|.    :.|.|.:|:  |..||
 Frog   300 SSMHPALPM---PLPPKKRGASMKTLNMRDIVWNIVQP-YKIILS----KGSRLNTED--SVLVR 354

  Fly    62 LQVFNQGRPYCLPVTSSYKAFGKR-WSWNEWVTLPLQFSDLPRSAML---VLTILDCSGAGQTTV 122
            ..:|:.....|.| |.:.:..||. ..|||.:...:...||||.|.|   :..:||
 Frog   355 AGLFHGTELLCKP-TMTPEVQGKNDHVWNETLEFEINVCDLPRMARLCFAIYAVLD--------- 409

  Fly   123 IGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQV 187
                                                    |.:..:|::.|.:.|..|.|
 Frog   410 ----------------------------------------KPRNKNKTKYQTIKKSGKMH----- 429

  Fly   188 QKVDWLDRLTFREIEVINEREKRMSDY-MFLMIEFPAIVVDDMYNYAVVYFEPEGDVK------- 244
            ..|.|::.:.|.     .:.:.|..|: :.....||. .:::|.|       |.|.|:
 Frog   430 FPVAWVNTMVFD-----YKGQLRSGDHVLHCWSSFPD-ELEEMLN-------PMGTVRTNPYTEN 481

  Fly   245 --------YKLPAKPKLVSVPDSEIQMENLVE--RKHHRLARSERSGISDRDAKPTASIRDQLHT 299
                    :....:|  :|.|..:..:|...|  |....|:.|.|.|         ..:..:|..
 Frog   482 TTTLHIKFHDYSKEP--ISYPPFDKILEKAAEIARNSDSLSTSGRGG---------KKLNIELKE 535

  Fly   300 IVYRYPPTYVLSSEEQDLVWKFRF-YLSSHKKALTKFLKCINW-KLEDEVTQALWMLANWAPMDV 362
            |:.| .|...||..|:||:|..|: ...:...:|.|.|..:.| |||| |.|...:|..|:.:..
 Frog   536 IMER-DPLCQLSENEKDLIWTLRYDCRENFPGSLPKLLLSVKWNKLED-VAQLQALLQIWSKLPP 598

  Fly   363 EDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVV 427
            .||||||...:....||:|||:.|....||:|..|||||||.||||
 Frog   599 RDALELLDFNYPDQYVREYAVNCLKPMSDEELSQYLLQLVQVLKYE------------------- 644

  Fly   428 RSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGS 492
                    ..||
 Frog   645 --------PFLD----------------------------------------------------- 648

  Fly   493 VALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSI 557
                                                  ..|..||:|||..|..:..:.:|:|..
 Frog   649 --------------------------------------CALSRFLLQRALDNRRIGQFLFWHLRS 675

  Fly   558 EVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVK------LVK 616
            ||.. .:|..|       :.::|:.:          .||...:::...|.::.|.|      |:|
 Frog   676 EVHN-PAVSVQ-------FGLLLEAY----------CRGSVAHMKVLSRQVEALNKLRTLNGLIK 722

  Fly   617 LVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAK 681
            |.|.:. ::.|..:.....|.| :.:|....:   |..||:|.|.::::|..:.....|.:.|..
 Frog   723 LNAVKL-SKVKNKDNMHTCLRE-NAYKEALMH---IQSPLNPSITLSELVVEKCKYMDSKMKPLW 782

  Fly   682 LTFVT-SIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQ 745
            :.:.. .........|||:|||||||.|.||::.|||.|.:...|||::.||..|||..:.||::
 Frog   783 IVYNNRGFGSDSLGIIFKNGDDLRQDMLALQLLRLMDMLWKEAGLDLRIVPYGCLATGDRCGFIE 847

  Fly   746 YVDSC-TVAEVLAREGNIH-----------NFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVIT 798
            .|.:. |:|::.....|:.           |:.::.|..|:     ....::.:..|||||||.|
 Frog   848 VVSAAETIADIQLDSSNLAAAAAFNKDALLNWIKECHSGDD-----LERAIEEFTLSCAGYCVAT 907

  Fly   799 YLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKE------------MVEAMGG 851
            |:||:||||.||:::...|:|||||||:|||.    .....|:.:|            :::....
 Frog   908 YVLGIGDRHNDNIMVRKTGQLFHIDFGHILGN----FKSKFKIKRERGPFILTYDFIHVIQQGKP 968

  Fly   852 ISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEE 916
            .::|....||:.|..|||.|||:.|:::.||:||:.|.:|:::...|  ::.|:::|.||..:|:
 Frog   969 GNTEKFGRFRQCCEDAYLILRRNGNLIITLFALMLTAGLPELSSVKD--IQYVKDSLALGKKEED 1031

  Fly   917 AVQHLQSLLDVSI 929
            |::..:...|.::
 Frog  1032 ALKQFRQKFDEAL 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	37/179 (21%)
		PI3Ka_III	284..561	CDD:238442	62/278 (22%)
		PI3Kc_III	601..945	CDD:270628	108/360 (30%)
pik3cb	NP_001072928.1	PI3K_p85B	35..108	CDD:460483
		PI3K_rbd	172..279	CDD:197540
		C2_PI3K_class_I_beta_delta	328..495	CDD:176075	45/241 (19%)
		PI3Ka_I	533..697	CDD:238444	66/301 (22%)
		PI3Kc_IA_beta	701..1062	CDD:270717	108/360 (30%)