DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and Pik3cb

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_083370.2	Gene:	Pik3cb / 74769	MGIID:	1922019	Length:	1064	Species:	Mus musculus

Alignment Length:	944	Identity:	229/944 - (24%)
Similarity:	369/944 - (39%)	Gaps:	289/944 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ILRFSGLYSEEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAML- 107
            :::.:.|.:||.....||..:|:.....|..|.||..:......|||.:...:...||||.|.|
Mouse   331 LVKGNKLNTEETVKVHVRAGLFHGTELLCKTVVSSEISGKNDHIWNEQLEFDINICDLPRMARLC 395

  Fly   108 --VLTILDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSK- 169
              |..:||                               :|                |.|:|:|
Mouse   396 FAVYAVLD-------------------------------KV----------------KTKKSTKT 413

  Fly   170 ---SQMQRLGKLAKKHRNGQVQKVDWLDRLTF------REIEVINEREKRMSDYMFLMIEFPAIV 225
               |:.|.:.|..|.|     ..|.|::.:.|      |..:||........|.:
Mouse   414 INPSKYQTIRKAGKVH-----YPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDEL---------- 463

  Fly   226 VDDMYNYAVVYFEPEGDVK---YKLPAKPKLVSVPDSEIQ------MENLVERKHHRLARSERSG 281
             ::|.|       |.|.|:   |...|....::.|:::.|      .:.::| |...||..:.:.
Mouse   464 -EEMLN-------PMGTVQTNPYAENATALHITFPENKKQPCYYPPFDKIIE-KAAELASGDSAN 519

  Fly   282 ISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFR-FYLSSHKKALTKFLKCINW-KLE 344
            :|.|..|...::   |..|:.| .|...|...|.||:|..| ....:..::|.|.|..|.| |||
Mouse   520 VSSRGGKKFLAV---LKEILDR-DPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLE 580

  Fly   345 DEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYED 409
            | |.|...:|..|..:...:|||||...:....||:|||..|.|..||:|..|||||||.||||
Mouse   581 D-VAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYE- 643

  Fly   410 PRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSD 474
                                      ..||
Mouse   644 --------------------------PFLD----------------------------------- 647

  Fly   475 KSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQ 539
                                                                    ..|..||::
Mouse   648 --------------------------------------------------------CALSRFLLE 656

  Fly   540 RACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQ 604
            ||..|..:..:.:|:|..|| ...:|..|       :.::|:.:.:    |:.   |....|.||
Mouse   657 RALDNRRIGQFLFWHLRSEV-HTPAVSVQ-------FGVILEAYCR----GSV---GHMKVLSKQ 706

  Fly   605 RRFIDEL-----------VKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDP 658
            ...:::|           |||.:...||..:...|...:::.|::             :..||:|
Mouse   707 VEALNKLKTLNSLIKLNAVKLSRAKGKEAMHTCLKQSAYREALSD-------------LQSPLNP 758

  Fly   659 EIYITKIVPMRTSLFKSALMPAKLTFVT-SIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRR 722
            .:.::::...:.....|.:.|..|.:.: :........|||:|||||||.|.|||:.|||.|.:.
Mouse   759 CVILSELYVEKCKYMDSKMKPLWLVYSSRAFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKE 823

  Fly   723 ENLDLKLTPYKVLATSSKHGFLQYVD-SCTVAEVLAREGNIH-----------NFFRKHHPCDNG 775
            ..|||::.||..|||..:.|.::.|. |.|:|::.....|:.           |:.::::..|:
Mouse   824 AGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDD- 887

  Fly   776 PYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGR-----DPKPM 835
                ....::.:..|||||||.:|:||:||||.||:::...|:|||||||:|||.     ..|..
Mouse   888 ----LDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRE 948

  Fly   836 PPPMKLSKEMVEAM-----GGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIAL 895
            ..|..|:.:.:..:     |  ::|....||:.|..|||.||||.|:.:.||:||:.|.:|::..
Mouse   949 RVPFILTYDFIHVIQQGKTG--NTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTS 1011

  Fly   896 EPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSI 929
            ..|  ::.::::|.||.::|||::..:...|.::
Mouse  1012 VKD--IQYLKDSLALGKSEEEALKQFKQKFDEAL 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	32/148 (22%)
		PI3Ka_III	284..561	CDD:238442	63/278 (23%)
		PI3Kc_III	601..945	CDD:270628	108/363 (30%)
Pik3cb	NP_083370.2	PI3K_p85B	35..112	CDD:197539
		PI3K_rbd	174..282	CDD:366310
		C2_PI3K_class_I_beta_delta	318..495	CDD:176075	47/233 (20%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250	404..412		4/23 (17%)
		PI3Ka_I	526..696	CDD:238444	65/304 (21%)
		PI3Kc_IA_beta	700..1061	CDD:270717	108/366 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820