DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K59F and Atr

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_003750609.1	Gene:	Atr / 685055	RGDID:	1305796	Length:	2636	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	97/489 - (19%)
Similarity:	182/489 - (37%)	Gaps:	133/489 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   572 AHDMYAMVL-----KMFLKVLENGNFNLRGI---FYNLRKQR--RFIDELVKLVKLVAKEPGNRN 626
            :||...:||     |:||...:...:.:..:   .|.:|..|  ..:.:.:.:.|.:.|..|:..
  Rat  2147 SHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILTKAIHMKKSLEKFVGDAT 2211

  Fly   627 KKTEKFQKL-----------------------LAEQDMFKVNFTNFEPIPFPLDPEI-------- 660
            :.|:|..:|                       |.|...|.......:.:..|..|.|
  Rat  2212 RLTDKLLELCNKSVDGSNSTLSMSTHFKMLKKLVEDPTFSEILIPLQSVMIPTLPSILGAHANHD 2276

  Fly   661 -------YIT---KIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMITL 715
                   |:.   .:|.:.:||.|    |.|::...|.... |..:.|..||||:|..:::..:|
  Rat  2277 PFPGHWAYLAGFDDVVEILSSLQK----PKKISLKGSDGKF-YIMMCKPKDDLRKDCRLMEFNSL 2336

  Fly   716 MDKLLRRE----NLDLKLTPYKVLATSSKHGFLQYVD---------------------------- 748
            ::|.||::    ..:|.:..|.|:..:.:.|.:::|:
  Rat  2337 INKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQC 2401

  Fly   749 ----SCTVAE--------VLAREGNI-HNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYL 800
                |..::|        :|.|...: |.:|.:..|.....|...:    .|.:|.|...::.|:
  Rat  2402 MLPKSAALSEKLKVFQEILLPRHPPVFHEWFLRTFPDPTSWYSSRS----AYCRSTAVMSMVGYI 2462

  Fly   801 LGVGDRHLDNLLLTT-NGKLFHIDFGYILGRDPK---PMPPPMKLSKEMVEAMGGISSEHHHEFR 861
            ||:||||.:|:|..: .|:..|:||..:..:...   |...|.:|:..||..||.:.:|  ..||
  Rat  2463 LGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTE--GLFR 2525

  Fly   862 KQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVK---KVEENLQLGLTDEEAVQHLQS 923
            :.|......:|.....::::....:.    |..:|..|.||   |...|....:.:|:|..|
  Rat  2526 RACEVTLRLMRDQREPLMSVLKTFLH----DPLVEWSKPVKGHSKAPPNETGEVVNEKAKTH--- 2583

  Fly   924 LLDVS------------ITAVMPALVEQIHRFTQ 945
            :||:.            :|.:..::...:|...|
  Rat  2584 VLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQ 2617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042
		PI3Ka_III	284..561	CDD:238442
		PI3Kc_III	601..945	CDD:270628	88/450 (20%)
Atr	XP_003750609.1	UME	1120..1226	CDD:214825
		FAT	1766..2087	CDD:280429
		TEL1	<2118..2636	CDD:227365	97/489 (20%)
		PIKKc_ATR	2285..2559	CDD:270625	61/288 (21%)
		FATC	2605..2636	CDD:280430	2/13 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900