DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pi3K59F and Pik3c3

DIOPT Version :9

Sequence 1:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_075247.1 Gene:Pik3c3 / 65052 RGDID:620899 Length:887 Species:Rattus norvegicus


Alignment Length:950 Identity:524/950 - (55%)
Similarity:658/950 - (69%) Gaps:73/950 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 DHFRYIHSSSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQVRLQVFNQGRP 70
            :.|.||:|..|...||:|:|:||||:.|..|:.:||||:|:|||||.|......|..|||.:|:|
  Rat     5 EKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKP 69

  Fly    71 YCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTVIGGTSISMFGKDG 135
            ..|||.:|||.|..||:||||:.||:::.||||:|.:.|||.|..|.|:...:|||::|:|||.|
  Rat    70 LALPVRTSYKPFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGRAVPVGGTTVSLFGKYG 134

  Fly   136 MFRQGMYDLRVWLGVEGDGNFPSRTPGKGKES-SKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFR 199
            ||||||:||:||..||.||:.|:||||:...: |:.||.||.||.|.||.|.:.|||||||||||
  Rat   135 MFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFR 199

  Fly   200 EIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQME 264
            |||:|||.|||.|::|:||:||..:..||. .|.:||:|.:||....:....:||.|||.::.||
  Rat   200 EIEMINESEKRSSNFMYLMVEFRCVKCDDK-EYGIVYYEKDGDESSPILTSFELVKVPDPQMSME 263

  Fly   265 NLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHK 329
            ||||.|||:||||.|||.||.|.||.|:.||||:.|| .||||..|:.||||||||||:||::.:
  Rat   264 NLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIV-SYPPTKQLTYEEQDLVWKFRYYLTNQE 327

  Fly   330 KALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDL 394
            |||||||||:||.|..|..|||.:|..|.||||||:|||||..:|:|.||:|||:||.||.||||
  Rat   328 KALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDL 392

  Fly   395 LLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDD--NGSLLDQSSLSDLSATSSGLHGSV 457
            |:||||||||||||:                     .||  ||          |..|......||
  Rat   393 LMYLLQLVQALKYEN---------------------FDDIKNG----------LEPTKKDSQASV 426

  Fly   458 IPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPAT---PGSSSLPCDSNSNALM 519
                              |.|..|:|.|.:....|..:.||..|..   |.|.|.......|   
  Rat   427 ------------------SESLSSSGVSSADIDSSQIITNPLPPVASPPPASKSKEVSDGEN--- 470

  Fly   520 LAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFL 584
                     :..:||||||.|||.|:|||||.|||:.:|.|: :..:::|.:.|:||..|::.|.
  Rat   471 ---------LEQDLCTFLISRACKNSTLANYLYWYVIVECED-QDTQQRDPKTHEMYLNVMRRFS 525

  Fly   585 KVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNF 649
            :.|..|:.::|.:...|..|:.|:|.||.|:|.|.:|.|||.||.|:.|.||.:.:  |:|.::.
  Rat   526 QALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNE--KMNLSDV 588

  Fly   650 EPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMIT 714
            |.||.||:|::.|..|:|...:|||||||||:|.|.|... .:|..||||||||||||||||:|:
  Rat   589 ELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDG-GKYPVIFKHGDDLRQDQLILQIIS 652

  Fly   715 LMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIHNFFRKHHPCDNGPYGI 779
            |||||||:||||||||||||||||:||||:|::.|..|||||..||:|.|||||:.|.:.||.||
  Rat   653 LMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSETGPNGI 717

  Fly   780 SAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKE 844
            ||||||||:|||||||||||:||||||||||||||..||||||||||||||||||:||||||:||
  Rat   718 SAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKE 782

  Fly   845 MVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQ 909
            |||.|||..||.:.|||||||||:|||||::|::||||||||||.:|||||||||.||||::..:
  Rat   783 MVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFR 847

  Fly   910 LGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK 949
            |.|:|||||.::|||:|.|:.|:..|:|||||:|.|||||
  Rat   848 LDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK 887

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042 86/159 (54%)
PI3Ka_III 284..561 CDD:238442 125/281 (44%)
PI3Kc_III 601..945 CDD:270628 232/343 (68%)
Pik3c3NP_075247.1 C2_PI3K_class_III 26..186 CDD:176042 86/159 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..170 10/20 (50%)
PI3Ka_III 283..503 CDD:238442 125/281 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 416..467 15/68 (22%)
PI3Kc_III 539..883 CDD:270628 232/346 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166353549
Domainoid 1 1.000 232 1.000 Domainoid score I2336
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1986
Inparanoid 1 1.050 1004 1.000 Inparanoid score I277
OMA 1 1.010 - - QHG54334
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 1 1.000 - - FOG0005021
OrthoInspector 1 1.000 - - oto98820
orthoMCL 1 0.900 - - OOG6_101850
Panther 1 1.100 - - LDO PTHR10048
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X3549
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

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