DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and pik3c2a

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_005159362.2	Gene:	pik3c2a / 571356	ZFINID:	ZDB-GENE-030328-39	Length:	1691	Species:	Danio rerio

Alignment Length:	912	Identity:	215/912 - (23%)
Similarity:	336/912 - (36%)	Gaps:	281/912 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PVTS----SYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTT------------V 122
            ||.|    :||:|.....|:|.:..|:..|.||..|||.|::..........            :
Zfish   727 PVQSKKVGTYKSFFYHIKWDELINFPISVSLLPLEAMLSLSLYGVLSQNANNSPDSNKQRKGPEL 791

  Fly   123 IGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQV 187
            :|..|:.:|....:..:|...|.:|...:.   ......|||:
Zfish   792 LGKVSMPLFDFRRVLSRGSKLLSLWTSPQA---LQPGAAGKGR---------------------- 831

  Fly   188 QKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPK 252
                             |..||     :.|.::||:..||      |:|..|:.:
Zfish   832 -----------------NPTEK-----IILQVDFPSPAVD------VLYVGPQEN---------- 858

  Fly   253 LVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDL 317
              ..|:.:         ....|.:.:||.|....|:.:                |:.||..::.|
Zfish   859 --GCPNPQ---------SLDPLDQDDRSEIEKLCARAS----------------TFGLSRADRQL 896

  Fly   318 VWKFRFYLSSHKKALTKFLKCI---NWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVR 379
            :|..|:|...::.:|.|.|...   :|....|:..   :|.:|..:....|||||...|...:||
Zfish   897 LWDQRYYCREYEYSLPKILASAPSWDWGSMGEIHA---LLHHWPALSPVSALELLESKFADTEVR 958

  Fly   380 KYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLS 444
            |.|||.:..:.|::|..||.|||||:|:|     .||
Zfish   959 KVAVSWIQSSSDDELADYLPQLVQAVKFE-----CHL---------------------------- 990

  Fly   445 DLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSL 509

Zfish   991 ----------------------------------------------------------------- 990

  Fly   510 PCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHD 574
                 .|||:               .||:.||..|..:|:|.||.|...|        ||.....
Zfish   991 -----KNALV---------------KFLLSRALGNVNIAHYLYWLLRDAV--------QDPAFGQ 1027

  Fly   575 MYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQ 639
            .|..:|.:.|.:...|   ||.   .|.||.|.:..|..|.:.| ::..:..::....:.|...|
Zfish  1028 RYERILCVLLCLCGTG---LRA---ELEKQTRLVQLLGALAEKV-RQASSSTRQVVLLEGLERVQ 1085

  Fly   640 DMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTS-IAHHEYAAIFKHGDDL 703
            ..|:.|...     .|:.|.:...::.....|.|.|..:|.|:..|.: ....|...:||.|:||
Zfish  1086 SFFQKNSCR-----LPISPSLVAKELNIKVCSFFNSNAVPLKIALVNADPLGDEINVMFKVGEDL 1145

  Fly   704 RQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSC-TVAEVLAREGNIHNF-- 765
            |||.|.||||.:||::..:|.|||::..:|.::|....|.::.|.|. |:.::....|...:|
Zfish  1146 RQDMLALQMIRIMDRIWLQEGLDLRIVNFKCISTGKDKGMVELVPSSETLRKIQVEYGVTGSFKD 1210

  Fly   766 ------FRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDF 824
                  .||::|.:: .|..::|   .:|.:|||.||.||:||:.|||.||::|.:.|.:|||||
Zfish  1211 KPLAEWLRKYNPAED-EYEKASE---NFIYTCAGCCVATYILGICDRHNDNIMLRSTGHMFHIDF 1271

  Fly   825 GYILG---------RDPKPMPPPMKLSKEMVEAMGG--ISSEHHHEFRKQCYTAYLHLRRHANVM 878
            |..||         ||    ..|..|:.:|...:.|  ..:.....|...|..||..:|:|:|:.
Zfish  1272 GKFLGHAQMIGSFKRD----RAPFVLTSDMAYVINGGERPTSRFQLFVDLCSQAYNLIRKHSNLF 1332

  Fly   879 LNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRF 943
            |||.|||..:.:|::....|  :|.|.:.||...||.||......|::.|:.:|.......||..
Zfish  1333 LNLLSLMTQSGLPELTGVQD--LKYVYDALQPQTTDAEATIFFTRLIESSLGSVATKFNFFIHNL 1395

  Fly   944 TQ 945
            .|
Zfish  1396 AQ 1397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	25/127 (20%)
		PI3Ka_III	284..561	CDD:238442	54/279 (19%)
		PI3Kc_III	601..945	CDD:270628	111/364 (30%)
pik3c2a	XP_005159362.2	Amelogenin	<137..207	CDD:330537
		PI3K_rbd	420..507	CDD:307097
		C2A_PI3K_class_II	681..852	CDD:175979	34/177 (19%)
		PI3Ka	872..1038	CDD:320871	61/310 (20%)
		PKc_like	1045..1397	CDD:328722	112/370 (30%)
		PX_PI3K_C2_alpha	1428..1536	CDD:132822
		C2B_PI3K_class_II	1565..1686	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820