DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and smg1

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_009297728.1	Gene:	smg1 / 569810	ZFINID:	ZDB-GENE-061013-767	Length:	3641	Species:	Danio rerio

Alignment Length:	1305	Identity:	231/1305 - (17%)
Similarity:	402/1305 - (30%)	Gaps:	477/1305 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SSLHERVQIK-----VGTLEGKKRQPDYEKLLEDPI--------------LRFSGL-YSEEHPSF 58
            |.|.:.::::     ||.:.....:.|.:....|.:              ||.|.| .|:..|:.
Zfish  1272 SELQKAIEVQLLRSAVGAISATNHEQDQKVASSDTLVKYLKQTGRICLGPLRLSTLTLSDSLPTL 1336

  Fly    59 QVRLQVF----------NQGRPYCL-PVTSSYKAFGKRWSWNEWV------TLPLQF------SD 100
            .. ||:.          ||....|| |:.|......|:.....|:      |...:|      |.
Zfish  1337 ST-LQLHCANSLENSLCNQHPEDCLIPLFSEALTTCKQQDVQPWLHALRYTTFQREFFQKLKGSS 1400

  Fly   101 LPRSAMLV---LTILDCSGAGQTTVIGGTSISMFGKDGM-----------FRQGMYDLRVWLGVE 151
            .|..:.|:   ||.:..:.......:....:|:..|..|           |||        |.:|
Zfish  1401 SPVDSHLMELCLTAVKFARKQGNIALATRLLSLCSKPAMSDTEGQDLVQSFRQ--------LSLE 1457

  Fly   152 GDGNFPSRTPGK--GKE-------------SSKSQMQRLGKLAKKH-RNGQVQ------------ 188
            |       |.|:  |.|             .|.|.|:.|...|..: .:|:.:
Zfish  1458 G-------TVGEKWGPELEIEKAKVLFAAGQSVSAMEMLSSCALSYCHSGKCELAACRSVLTLCK 1515

  Fly   189 --KVDWLDRLTFREIEVINER---------EKRMSDYMFLMIE---FPAIVVDDMYNYAVVYFEP 239
              ..||.| ||.:...|:.:.         .|.:|..:.|.:|   .|.|..:...:..|  .||
Zfish  1516 WLLADWKD-LTPQLKMVVKKNSGSTSLSTLSKNISGLLELPLEDQGMPHITTETTVSVGV--GEP 1577

  Fly   240 E---GDVKYKLPA--KPKLV---------------SVPDSEIQMEN----LVERKHHRLARSERS 280
            :   |.: |:|..  .|::.               .|.|:..|.|.    |.|:|  .:.....:
Zfish  1578 DFVLGQL-YQLSTTQAPEVAKSWAALASWAYRWGRKVVDNASQGEGVPLLLGEKK--EIEELLPA 1639

  Fly   281 GISDRDAKPT------------ASIRDQLHTIVYRYPPTYVLSSEEQ------DLVWKFRFYLSS 327
            |.||.| |.|            |.|:|:          ...|.:||.      |::.:
Zfish  1640 GTSDED-KETIFGILGQAMCRPAGIQDE----------DMALQNEEDDEDDMVDVIGR------- 1686

  Fly   328 HKKALTKFLKCINW--KLEDEVTQAL---W-----------------------MLANWAPMDVED 364
                  :.|....|  .:||.||..|   |                       :.|...|:|.:|
Zfish  1687 ------QLLGACPWLSDVEDTVTDGLIGVWRRVVDRIFSLYRVSCRAYFTFLKLNAGQVPIDEDD 1745

  Fly   365 ALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHL-----HGC----I 420
            ...||:.            ....|:.|:.:::..|:|::.|    .:|...|     ||.    .
Zfish  1746 PKLLLNN------------QNSKQSSDDVIVMATLRLLRLL----VKHAGELREGLEHGLASTPT 1794

  Fly   421 FPERDVVRSI---LDDNGSLLDQSSLSDLSAT---------------SSGLHGSVIPANQRAASV 467
            .|.|.::..:   |:...:.:.||..|.|...               |..|.|....|..:..|.
Zfish  1795 APWRGIIPQLFSRLNHPEAYIRQSICSLLCRVAQDSPHLILYPAIVGSISLGGEAQTAGNKLPSS 1859

  Fly   468 LAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALM------LAEGISF 526
            |..:..:.. ..|..||....|.|..     |..::.|...:...|...|:|      :.:.:|.
Zfish  1860 LPTLLGNMQ-GEGLCGGESETGSGPT-----SQESSRGEEMVMYSSEDQAMMQDCYSKIVDKLSS 1918

  Fly   527 GSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRK----QDERAHDMYAMVLKMFLKVL 587
            .:....|...::.......||.....|...::.:.:..:|:    :||             :|.:
Zfish  1919 ANPTMVLQVQMLVGELRRVTLLWDELWLGVLQQQHMHVLRRIQQLEDE-------------VKRV 1970

  Fly   588 ENGNFNLRGIFYNLRKQRRF-----------------IDELVKLVKLVAKEPGNR---------- 625
            :|.|        .|||..:.                 :|.:..:....|:.|...
Zfish  1971 QNNN--------TLRKDEKVAIMREKHSALMKPVVFALDHVRSITAAPAETPHEEWFQETYGDAI 2027

  Fly   626 ------------------------------NKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEI 660
                                          .::.:|....|...|......|........|..|:
Zfish  2028 HNALERLRSPLNPANPASSWVPFKQIMLSLQQRAQKRASYLLRLDEISPRLTAMANTEMALPGEV 2092

  Fly   661 YITKIVPMRT-----SLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMI----TLM 716
            ..|..|.:::     ::..:...|.||.|:.|...: |..:||..:||..|:.|:|.:    |:.
Zfish  2093 SATDAVTIQSVGNTITILPTKTKPKKLYFLGSDGRN-YPYLFKGLEDLHLDERIMQFLSIVNTMF 2156

  Fly   717 DKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCT--------------VAEVLAREGNIHN--- 764
            .|:.::|:...:...|.|....::.|.:|:||..|              |.:....:.:...
Zfish  2157 TKVNQQESPRFQARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAVVQAQKAQDSFQQPQN 2221

  Fly   765 ----------FFRKHHPC------------DNGPYGISAEVM----------------------- 784
                      ::.|..|.            .:.|..:..:|:
Zfish  2222 LPMVPRPSELYYSKISPALKAVGLSLDVSRRDWPLSVMRDVLRELMEATPPNLLAKELWCSCTTP 2286

  Fly   785 -------DTYIKSCAGYCVITYLLGVGDRHLDNLLL-TTNGKLFHIDFGYILGRDPK---PMPPP 838
                   .||.:|.|...::.|::|:|||||||:|: .|.|::.|||:.....:...   |...|
Zfish  2287 SEWWSVTQTYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVP 2351

  Fly   839 MKLSKEMVEAMG-----GISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMV-DATVPDIA--- 894
            .:::..:..|:|     ||       ||..|......:||....:|.|....| |..|...|
Zfish  2352 FRMTHNIETALGVTGVEGI-------FRLSCEQVVQIMRRGRETLLTLLEAFVYDPLVDWTAGGE 2409

  Fly   895 --------------LEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVS-------ITAVMPALVE 938
                          .|..::.:::|.::...|......:     :.|:       :|.|:|.|.|
Zfish  2410 VGFAGAVYGGGGQQAENKQSKREMERDITRSLFSSRVAE-----IKVNWFKNRDEMTGVLPQLEE 2469

  Fly   939 QIHRF 943
            .:..:
Zfish  2470 AVDEY 2474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	43/226 (19%)
		PI3Ka_III	284..561	CDD:238442	62/355 (17%)
		PI3Kc_III	601..945	CDD:270628	87/512 (17%)
smg1	XP_009297728.1	HEAT repeat	143..173	CDD:293787
		HEAT repeat	183..216	CDD:293787
		HEAT repeat	223..254	CDD:293787
		SMG1	622..1231	CDD:292413
		PIKKc_SMG1	2100..2406	CDD:270714	63/313 (20%)
		FATC	3611..3640	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900