Protein Alignment Pi3K59F and pik3c2b

DIOPT Version :10

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: XP_003199535.2
• Gene: pik3c2b / 567938
• ZFINID: ZDB-GENE-050309-145
• Length: 1587
• Species: Danio rerio
• Alignment Length: 946
• Identity: 211/946 - (22%)
• Similarity: 352/946 - (37%)
• Gaps: 301/946 - (31%)

  Fly    51 YSEEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRW----SWNEWVTLPLQFSDLPRSAMLVLTI 111
            ::..:.:|.:...:.:.|...|.|..:|.::..|..    .|::.|..|:|.:.|||.:.|.:|:
Zfish   592 WAASYENFFLSCSLTHGGVELCAPQHTSKQSVSKYLFHLVVWDQRVCFPVQINQLPRESQLTVTL 656

  Fly   112 LDC-----SGAGQTT-------VIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKG 164
            ...     .||.:.:       .:|..::.:|....:...|...|.:|....|.||..|.||...
Zfish   657 YATPLPPPGGAEEKSKQKRSIESLGWVTMPLFNFRHVLTCGRKLLGLWPSTPGSGNARSSTPNFS 721

  Fly   165 KESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDM 229
            :                                              .|.:.|.::||.
Zfish   722 Q----------------------------------------------PDSVILQVDFPT------ 734

  Fly   230 YNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIR 294
                     ...:|::..||..:.  .|..|.               |....:|.|
Zfish   735 ---------SSFEVRFSTPAPAEF--SPQYEF---------------SHLDQVSQR--------- 764

  Fly   295 DQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFL-KCINWKLEDEVTQALW------ 352
             |||.:::: ...:.||.|::.|:|:.|::.......|...| ...:|:         |
Zfish   765 -QLHDVLHK-KSLFWLSPEDRRLLWEKRYFCHVEASRLPLVLASAPSWE---------WACLPDI 818

  Fly   353 --MLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVH 415
              :|..|..|:..|||.||:.||...:.|:.||..:....|.:||.:|.|||||||||
Zfish   819 YALLRQWGCMNHLDALGLLNATFPDQECRRTAVQWMDSISDPELLDFLPQLVQALKYE------- 876

  Fly   416 LHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPG 480
               |                 .||
Zfish   877 ---C-----------------YLD----------------------------------------- 880

  Fly   481 SAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNA 545
                                                              ::|..||::||..:.
Zfish   881 --------------------------------------------------SHLVRFLLRRAIGDV 895

  Fly   546 TLANYFYWYLSIEVEEVE-SVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFID 609
            .:|:|.:|.|...:::.: |||         |..:|...|..  :|    ||:.....:|...::
Zfish   896 RIAHYLFWLLKDTLQDSQFSVR---------YQYLLAALLCC--SG----RGLREEFDRQCWLVN 945

  Fly   610 ELVKLVKLVAK-EPGNRNKKTEKFQKLLAE-----QDMFKVNFTNFEPIPFPLDPEIYITKIVPM 668
            .|.|:.:.|.: .|.:|       |.:|.|     :..|.:|    .....||:|.:.:..|...
Zfish   946 VLAKVAQRVREASPSSR-------QAILREGLDDVKQFFSIN----SSCRLPLNPGLLVKGINIQ 999

  Fly   669 RTSLFKSALMPAKLTFVTSIAHH---EYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLT 730
            ..|.|.|..:|.||:|...  .|   ....|||.|||||||.|.||:|.:|:|:..:|.||:::.
Zfish  1000 SCSYFNSNAVPLKLSFQNQ--DHLGDNINVIFKAGDDLRQDMLTLQIIRIMNKIWVQEGLDMRMV 1062

  Fly   731 PYKVLATSSKHGFLQYVDSC-TVAEVLAREGNIHNF--------FRKHHPCDNGPYGISAEVMDT 786
            .::..:|....|.::.:.|. |:.::....|...:|        .:||:|.:. .|   .:.::.
Zfish  1063 IFRCFSTGRGRGMVEMIPSAETLRKIQVEHGVTGSFKDRPLADWLQKHNPTEE-EY---EKAVEN 1123

  Fly   787 YIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGR-----DPKPMPPPMKLSKEMV 846
            :|.||||.||.||:||:.|||.||::|.|:|.:||||||..||.     :.|....|...:.:|.
Zfish  1124 FIYSCAGCCVATYILGICDRHNDNIMLKTSGHMFHIDFGKFLGHAQMFGNIKRDRAPFVFTSDMA 1188

  Fly   847 EAMGG--ISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQ 909
            ..:.|  ..|...|:|...|..||..:|:||::.|||..||:.:.:|:::...|  :|.|.:.|:
Zfish  1189 YVINGGDKPSSRFHDFVDLCCEAYNRIRKHAHLFLNLLGLMLSSGIPELSDVDD--LKYVYDALR 1251

  Fly   910 LGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQ 945
            ...::.:|..|...|::.|:.:|...|...||...|
Zfish  1252 PHESEADATMHFTRLIESSLGSVATKLNFFIHNLAQ 1287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	28/150 (19%)
		PI3Ka_III	284..561	CDD:238442	52/285 (18%)
		PI3Kc_III	601..945	CDD:270628	110/368 (30%)
pik3c2b	XP_003199535.2	None