DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K59F and si:rp71-17i16.5

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_021329311.1	Gene:	si:rp71-17i16.5 / 564261	ZFINID:	ZDB-GENE-090312-117	Length:	1069	Species:	Danio rerio

Alignment Length:	998	Identity:	233/998 - (23%)
Similarity:	367/998 - (36%)	Gaps:	329/998 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PDD-----HFRYIHS----SSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQ 59
            |||     ::..:.|    ||.||.:.:|             :|.:||.:|  ..|:..|. .|:
Zfish   294 PDDTVSTEYWPLVDSLTGLSSSHEELCLK-------------KKEVEDIVL--ISLWDCER-KFR 342

  Fly    60 VRLQVFN-------------------QGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSA 105
            |:|..|:                   .|:.....:.|:.|.|.....||.|:...:...|:|:.|
Zfish   343 VKLLGFDIPDLPSKVPSLVYVEATIIYGKKTISSICSTPKEFTDEVLWNTWLEFDILIRDIPQGA 407

  Fly   106 MLVLTILDCSGA---------------GQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGN 155
            .|.|||.....|               |:..|:...::.:.....:..||.:.|.:|...|.|
Zfish   408 KLGLTINATEAAKETKSSSSKVPDHHKGKLQVLYFVNLQLIDHRSLLSQGPHTLNMWPFPEWD-- 470

  Fly   156 FPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIE 220
                     :|:...:..:|.                    |....:|.|.          :.|.
Zfish   471 ---------EEAVTYEADKLS--------------------TATNPDVANS----------MAIT 496

  Fly   221 FPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDR 285
            |    :.|.|::.||.  |.|.........|              :.|.....||...|......
Zfish   497 F----MLDRYSFPVVL--PNGRSSSCSGTSP--------------VSESSSLDLAGESRLSAPFS 541

  Fly   286 DAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQA 350
            :|..||::....:...::....:.:|:                   |.:||:.:||.|...|.:.
Zfish   542 EASSTATLTRMRNLKKFKEESVHYVSN-------------------LPQFLRTVNWMLPTVVQEV 587

  Fly   351 LWMLANWAPMDVE--DALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHI 413
            .|:|::|.|.|:|  .||||||..|...:||:.||.||....::::|.|||||||.||.|
Zfish   588 HWLLSHWGPEDIELFVALELLSVDFADLKVRRLAVQRLEILSNDEVLKYLLQLVQTLKVE----- 647

  Fly   414 VHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVS 478
                    |..|
Zfish   648 --------PYHD----------------------------------------------------- 651

  Fly   479 PGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACT 543
                                                          ||      |..||::||..
Zfish   652 ----------------------------------------------SF------LARFLLKRALR 664

  Fly   544 NATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFI 608
            :..:.::|:|||..||......|::       .|::|:.:|  |..|...| ..|.:..:...::
Zfish   665 SKRIGHFFFWYLRSEVAGCPFFRQR-------MAVILEAYL--LGCGEAML-AEFQSQVQVVSYL 719

  Fly   609 DELVKLVKLVAKEPGN-RNKKTEKFQKLLAEQDM---FKVNFTNFEPIPFPLDPEIYITKIVPMR 669
            .::...|||:..:..: .:...:|.|:||.:.|:   |:|          |.||.:....|:...
Zfish   720 HDVALAVKLLYPDRTDLPSTAPQKLQELLEKCDLPSDFQV----------PFDPRVRAGSIILKD 774

  Fly   670 TSLFKSALMPAKLTFVTSIAHHE------YAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLK 728
            ..:..|...|..|.|  |....|      ...|||||||||||.||:|.:.:||.:.:.:.|||.
Zfish   775 CKIMASKKKPLWLEF--SCIQSEAPPSPPVGIIFKHGDDLRQDMLIIQTLVVMDSIWQEKGLDLN 837

  Fly   729 LTPYKVLATSSKHGFLQYV-DSCTVAEVLAREGNIHNFFR----------------KHHPCDNGP 776
            |.||..::|....|.::.| ::.|:|.|...:|.:...|:                ||.
Zfish   838 LVPYGCISTGFNIGMIEIVRNAITIASVQRSQGGVAGAFKNNALYDWLQTKCPFQEKHF------ 896

  Fly   777 YGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDP-----KPMP 836
                 :..:.::.|||||||.||:||:||||.||:::|..|.|||||||:|||...     ....
Zfish   897 -----QATEKFVNSCAGYCVATYVLGIGDRHNDNIMITDQGNLFHIDFGHILGNTKSFWGVNRER 956

  Fly   837 PPMKLSKEMVEAMG---GISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPD 898
            .|..|:.:.:..||   |..|.:...||..|..|||.||..:.:::.|||||:...:|::::..|
Zfish   957 VPFVLTPDFLYVMGRVKGRPSLYFQRFRDTCINAYLSLRAQSRLLVTLFSLMLLTGIPELSMSQD 1021

  Fly   899 KAVKKVEENLQLGLTDEEAVQHL 921
            ....:..  ||...::|||..||
Zfish  1022 MLYLRTA--LQQDQSEEEARNHL 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	35/192 (18%)
		PI3Ka_III	284..561	CDD:238442	56/278 (20%)
		PI3Kc_III	601..945	CDD:270628	109/356 (31%)
si:rp71-17i16.5	XP_021329311.1	PI3K_rbd	189..292	CDD:321949
		C2	332..506	CDD:326325	38/219 (17%)
		PI3Ka	557..702	CDD:320871	58/290 (20%)
		PI3Kc_IB_gamma	706..1069	CDD:270627	111/363 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820