DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and pik3ca

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_009304451.1	Gene:	pik3ca / 561737	ZFINID:	ZDB-GENE-130409-1	Length:	1069	Species:	Danio rerio

Alignment Length:	924	Identity:	209/924 - (22%)
Similarity:	356/924 - (38%)	Gaps:	291/924 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 VRLQVFNQGRPYCLPV-TSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTV- 122
            ||..:::.|...|..| |........|  ||||:|..:...|:||:|.|.|:|  ||..|:...
Zfish   356 VRTGIYHGGEQLCDNVNTQRVPCSNPR--WNEWLTYDMYIPDIPRAARLCLSI--CSVKGRKGAK 416

  Fly   123 -----IGGTSISMFGKDGMFRQGMYDLRVW------------LGVEGDGNFPSRTPGKGKESSKS 170
                 :...::::|........|...|.:|            :||.| .|....||
Zfish   417 EEHCPLAWGNVNLFDYTHTLVSGKMALNLWPVPHGLEDLLNPIGVTG-SNPNKETP--------- 471

  Fly   171 QMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAI-VVDDMYNYAV 234
                                       ..|:|.         ||....::||.: .::|..|:
Zfish   472 ---------------------------CLELEF---------DYFSSPVKFPDMATIEDHANW-- 498

  Fly   235 VYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERK-HHRLARSERSGISDRDAKPTASIRDQLH 298
                                           ::.|: .:...:|.:|....||...|.:..:||.
Zfish   499 -------------------------------IISREMGYNYCQSGQSSRVARDHAMTEADIEQLR 532

  Fly   299 TIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLANWAPMDVE 363
            .:..| .|...::.:|:|.:|:.|.|..:..:.|.|.|..:.|...|||.|...:|.:|..:..|
Zfish   533 QLGNR-DPLSEITEQEKDFLWRHRQYCVNIPEILPKILLAVKWNSRDEVAQMYCLLKDWPAIKPE 596

  Fly   364 DALELLSPTFTHPQVRKYAVSRLAQ-APDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVV 427
            .|:|||...:..|.:|.:||..|.: ..|:.|..||:||||.||||.
Zfish   597 QAMELLDCNYPDPMIRDFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQ------------------ 643

  Fly   428 RSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGS 492

Zfish   644 ----------------------------------------------------------------- 643

  Fly   493 VALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSI 557
             .|.||                                  |..||:::|.||..:.::|:|:|..
Zfish   644 -YLDNP----------------------------------LVRFLLKKALTNQRIGHFFFWHLKS 673

  Fly   558 EVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEP 622
            |:.. ::|.::.....:.|.....|:||              :|.:|...:::|:.|..::.:|
Zfish   674 EMHN-KTVSQRFGLLLESYCRACGMYLK--------------HLSRQVEAMEKLINLTDILKQE- 722

  Fly   623 GNRNKKTEKFQ-KLLAEQ-------DMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMP 679
              :..:|:|.| |.|.||       |..: |||:      ||:|...:..:......:..||..|
Zfish   723 --KKDETQKVQMKFLVEQMRRPDYMDALQ-NFTS------PLNPAHQLGNLRLEDCRIMSSAKRP 778

  Fly   680 AKLTF-----VTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSS 739
            ..|.:     ::.:.......|||:|||||||.|.||:|.:|:.:.:.:.|||::.||..|:...
Zfish   779 LWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGD 843

  Fly   740 KHGFLQYV-DSCTVAEVLAREG----------NIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAG 793
            ..|.::.| .|.|:.::..:.|          .:|.:.:     |.....:....:|.:.:||||
Zfish   844 CVGLIEVVRSSHTIMQIQCKGGLKGALQFNSTTLHQWLK-----DKNKGEMYDMAIDLFTRSCAG 903

  Fly   794 YCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPM-----PPPMKLSKE--MVEAMGG 851
            |||.|::||:||||..|:::..:|:|||||||:.|....|..     ..|..|:::  :|.:.||
Zfish   904 YCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGG 968

  Fly   852 ----ISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGL 912
                ..:.....|::.||.|||.:|:|||:.:||||:|:.:.:|::....|  :..:.:.|.|..
Zfish   969 TQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDD--IAYIRKTLALDK 1031

  Fly   913 TDEEAVQHLQSLLD 926
            |::||:.:....::
Zfish  1032 TEQEALDYFMKQMN 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	32/144 (22%)
		PI3Ka_III	284..561	CDD:238442	57/277 (21%)
		PI3Kc_III	601..945	CDD:270628	104/361 (29%)
pik3ca	XP_009304451.1	PI3K_p85B	31..108	CDD:197539
		PI3K_rbd	173..292	CDD:307097
		C2_PI3K_class_I_alpha	325..484	CDD:176043	36/177 (20%)
		PI3Ka_I	529..696	CDD:238444	56/286 (20%)
		PKc_like	695..1065	CDD:328722	107/382 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820