DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K59F and pi4kaa

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_009303356.1	Gene:	pi4kaa / 556956	ZFINID:	ZDB-GENE-100204-2	Length:	2128	Species:	Danio rerio

Alignment Length:	775	Identity:	161/775 - (20%)
Similarity:	276/775 - (35%)	Gaps:	268/775 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 KYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTY 308
            ||.:..:..|:::..|||:.   :...::.|:..|.       |.||   ...:.|.:..:...|
Zfish  1507 KYYMKRRTLLLALLASEIER---LSTWYNPLSTQEL-------AIPT---EQSVETSISNWRSKY 1558

  Fly   309 VLSSEEQ-----DLVWKFRFYLS----------------------------SHKKALTKFLKCIN 340
            :..:|:|     :|.|....||:                            |......|||  :.
Zfish  1559 INLTEKQWKDNVNLAWSIAPYLALQLPARFKNADAIVAEVTRLVRLDPGAVSDVPEAVKFL--VT 1621

  Fly   341 WKLEDEVTQALWMLANWAPMDVEDALELLSPTF-THPQVRKYAVSRLAQAPDEDLLLYLLQLVQA 404
            |...|..:..|..:..|||.|....|...|..: .||...:|.|..|...|.:.:|.|:.|:|||
Zfish  1622 WHTIDADSPELSHILCWAPADPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQA 1686

  Fly   405 LKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLA 469
            |:|:...::                                                 |...:.|
Zfish  1687 LRYDKMGYV-------------------------------------------------REYILWA 1702

  Fly   470 AIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLC 534
            |.||.
Zfish  1703 AQKSQ------------------------------------------------------------ 1707

  Fly   535 TFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRG--- 596
                       .||:.|.|.:...:       ..||..|.....:.::..:::|....:|.|
Zfish  1708 -----------LLAHQFIWNMKTNI-------FLDEEGHQKDPDIGELLEQMVEEITHSLSGPAK 1754

  Fly   597 IFYNLRKQRRF-----IDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEP-IPFP 655
            .||    ||.|     |..:..::|.|.|  |:..|:.  ..|.|:|   .||     :| ...|
Zfish  1755 DFY----QREFDFFNKITNVSAIIKPVPK--GDERKRA--CLKALSE---IKV-----QPGCYLP 1803

  Fly   656 LDPEIYITKI-----VPMRTSL-------FK--------------------------SALMPAKL 682
            .:||..:..|     .||:::.       ||                          |:|...::
Zfish  1804 SNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCPSDSQDEGDESSLTAQRV 1868

  Fly   683 TFVTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYV 747
            .:        .|||||.|||.|||.|.||:|.|...:.:...|||.:.||:|:||:...|.::.:
Zfish  1869 CW--------QAAIFKVGDDCRQDMLALQIIGLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECI 1925

  Fly   748 DSCTVAEVLAREGN--IHNFFRKHHPCDNGPYGISA-----EVMDTYIKSCAGYCVITYLLGVGD 805
            ..|...:.|.|:.:  ::::||..       ||..:     :....:|:|.|.|.::.:||.:.|
Zfish  1926 PDCKSRDQLGRQTDFGMYDYFRNQ-------YGDESTLAFQKARYNFIRSMAAYSLLLFLLQIKD 1983

  Fly   806 RHLDNLLLTTNGKLFHIDFGYILGRDP---KPMPPPMKLSKEMVEAMGG-ISSEHHHEFRKQCYT 866
            ||..|::|.:.|.|.|||||::....|   ....|.:||:.|||..||| :.:.....|.:.|..
Zfish  1984 RHNGNIMLDSKGHLIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVR 2048

  Fly   867 AYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLD 926
            .||.:|.:.:.:::|.:||:|..:|...   .:.:|.:::.....::::||...:..:::
Zfish  2049 GYLAVRPYMDAVVSLVTLMLDTGLPCFR---GQTIKLLKQRFNPNMSEKEAAAFMIKVIE 2105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042
		PI3Ka_III	284..561	CDD:238442	47/310 (15%)
		PI3Kc_III	601..945	CDD:270628	98/381 (26%)
pi4kaa	XP_009303356.1	PI4Ka	1573..1748	CDD:238443	43/303 (14%)
pi4kaa	XP_009303356.1	PI4Kc_III_alpha	1809..2127	CDD:270711	80/315 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810