DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and pik3c3

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_021333200.1	Gene:	pik3c3 / 548346	ZFINID:	ZDB-GENE-050410-13	Length:	887	Species:	Danio rerio

Alignment Length:	954	Identity:	533/954 - (55%)
Similarity:	672/954 - (70%)	Gaps:	80/954 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DHFRYIHSSSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQVRLQVFNQGRP 70
            |.|.|::|..|...||:|:|:||||:.|..|:.|||||:|||||||.|......|..|||.:|:|
Zfish     4 DKFNYVYSCDLDINVQLKIGSLEGKREQKSYKALLEDPMLRFSGLYQESCSDLYVTCQVFAEGKP 68

  Fly    71 YCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTVIGGTSISMFGKDG 135
            ..|||.:|||||..||:||||:.||:::.|||:||.:.||:.|..|.|:.|.:|||::::|||.|
Zfish    69 LALPVRTSYKAFSTRWNWNEWLRLPVKYPDLPQSAQVTLTVWDVYGPGRATPVGGTTVTLFGKYG 133

  Fly   136 MFRQGMYDLRVWLGVEGDGNFPSRTPGKGKES-SKSQMQRLGK---------LAKKHRNGQVQKV 190
            ||||||:||:||.||||||..|:.|||:...| ::.||.||.|         |.|.||.|.:.||
Zfish   134 MFRQGMHDLKVWPGVEGDGTEPTSTPGRTSSSLAEDQMGRLAKGPDLEILSDLTKAHRQGHMVKV 198

  Fly   191 DWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVS 255
            ||||||||||||:|||.|||.|::|:||:|||.:...:. .|::||:|.:.|....||....:|.
Zfish   199 DWLDRLTFREIEMINESEKRSSNFMYLMVEFPRVKSGER-EYSIVYYEKDADESSPLPTSSDIVK 262

  Fly   256 VPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWK 320
            |||.::.||||||.|||:||||.|||.||.|.||.|:.||||:.|| .||||..|||||||||||
Zfish   263 VPDPQMCMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV-SYPPTKQLSSEEQDLVWK 326

  Fly   321 FRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSR 385
            ||:||::.:|||||||||:||.|..|..|||.:|..|.||||||:|||||..||:|.||:|||:|
Zfish   327 FRYYLTTQEKALTKFLKCVNWDLPQEAKQALELLGKWRPMDVEDSLELLSSQFTNPTVRRYAVAR 391

  Fly   386 LAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATS 450
            |.||.|||||:||||||||||||:...|   .|.:.|...     .|:.|.|.:.|:..||.::.
Zfish   392 LQQADDEDLLMYLLQLVQALKYENFNDI---QGGLEPANK-----RDNQGGLTESSTTGDLDSSQ 448

  Fly   451 SGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNS 515
            .....:|:|::|:                   |..|:.|:
Zfish   449 LASAIAVMPSSQK-------------------GKEGTDGE------------------------- 469

  Fly   516 NALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVL 580
                        ::..:||||||.|||.|:|||||.|||:.:|.|: :..:::|.:.||||..|:
Zfish   470 ------------NLEQDLCTFLISRACKNSTLANYLYWYVIVECED-QDTQQRDPKTHDMYLNVM 521

  Fly   581 KMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVN 645
            :.|.:.|..|:.::|.:...|..|:.|:|.||:|:|.|.:|.|||.||||:.|.|||:.:  |||
Zfish   522 RRFSQALLKGDKSVRVMRSLLASQQTFVDRLVQLMKAVQRESGNRKKKTERLQSLLADNE--KVN 584

  Fly   646 FTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLIL 710
            .:..||||.||:|:|.|..|:|...:|||||||||||.|.|... .:|..|||||||||||||||
Zfish   585 LSEIEPIPLPLEPQIRIKGIIPETATLFKSALMPAKLIFKTEDG-EQYPVIFKHGDDLRQDQLIL 648

  Fly   711 QMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIHNFFRKHHPCDNG 775
            |:|:|||||||:||||||||||||||||:||||:|:|.|..||||||.||||.:||||:.|.|.|
Zfish   649 QIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFVQSVPVAEVLATEGNIQSFFRKYAPNDKG 713

  Fly   776 PYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMK 840
            |||||:||||||:|||||||||||:||||||||||||||..||||||||||||||||||:|||||
Zfish   714 PYGISSEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMK 778

  Fly   841 LSKEMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVE 905
            |||||||.|||:.||.:.|||||||||:|||||::|::||||||||||.:|||||||||.||||:
Zfish   779 LSKEMVEGMGGMQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQ 843

  Fly   906 ENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK 949
            :..:|.|:|||||.::|||:|.|:.|:..|:|||||:|.||||:
Zfish   844 DKFRLDLSDEEAVHYMQSLIDESVGALFAAVVEQIHKFAQYWRR 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	89/168 (53%)
		PI3Ka_III	284..561	CDD:238442	122/276 (44%)
		PI3Kc_III	601..945	CDD:270628	242/343 (71%)
pik3c3	XP_021333200.1	C2_PI3K_class_III	25..194	CDD:176042	89/168 (53%)
		PI3Ka_III	291..503	CDD:238442	122/276 (44%)
		PI3Kc_III	539..883	CDD:270628	242/346 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595681
Domainoid	1	1.000	233	1.000	Domainoid score	I2340
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1986
Inparanoid	1	1.050	1035	1.000	Inparanoid score	I266
OMA	1	1.010	-	-		QHG54334
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0005021
OrthoInspector	1	1.000	-	-		oto38917
orthoMCL	1	0.900	-	-		OOG6_101850
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3549
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770