Protein Alignment Pi3K59F and PI4KA

DIOPT Version :9

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_477352.3
• Gene: PI4KA / 5297
• HGNCID: 8983
• Length: 2102
• Species: Homo sapiens
• Alignment Length: 986
• Identity: 203/986 - (20%)
• Similarity: 350/986 - (35%)
• Gaps: 297/986 - (30%)

  Fly    11 IHSSSLHERVQIKVGTLEGKKRQ------PDYEKLLEDPILRFSGLYSEEHPSFQV----RLQVF 65
            |.||.|...:.:.:|..:|...:      |.: |||   .|..|.|:::..|:..:    |.:::
Human  1319 IFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRF-KLL---TLGLSLLHADVVPNATIRNVLREKIY 1379

  Fly    66 NQGRPY--CLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTVIGGTSI 128
            :....|  |.|   .:...|:: ...|.:::.::|.....|....||.................|
Human  1380 STAFDYFSCPP---KFPTQGEK-RLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDI 1440

  Fly   129 SMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWL 193
            :: |......||      |:     ..:| .:.|....|.||.|.:     |.:|..|:.|. ::
Human  1441 TV-GSRQQATQG------WI-----NTYP-LSSGMSTISKKSGMSK-----KTNRGSQLHKY-YM 1486

  Fly   194 DRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPD 258
            .|.|                   |::...|..::.:    :.::.|              :|.|:
Human  1487 KRRT-------------------LLLSLLATEIERL----ITWYNP--------------LSAPE 1514

  Fly   259 SEIQM--ENLVERKHHRLARSERSGISDRDAKPTASIRDQLH-----TIVYRYPPTYVLSSEEQD 316
            .|:..  ||.|..     .||:...:|::..|...::...:.     .:..|:..|..:.:|...
Human  1515 LELDQAGENSVAN-----WRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTR 1574

  Fly   317 LVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTF-THPQVRK 380
            ||......:|...:|: |||  :.|...|.....|..:..|||.|....|...|..: .||...:
Human  1575 LVRLDPGAVSDVPEAI-KFL--VTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQ 1636

  Fly   381 YAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHI------------VHLHGCIFPERDVVRSILD- 432
            |.|..|...|.:.:|.|:.|:||||:|:...::            :..|..|:..:..:  .||
Human  1637 YGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTNI--YLDE 1699

  Fly   433 -------DNGSLLDQ------SSLS-----------DLSATSSGLHGSVIP---ANQRAASVLAA 470
                   |.|.||||      .|||           |.....:.:...:.|   .::|..:.|:|
Human  1700 EGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSA 1764

  Fly   471 IKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCT 535
            : |:..|.||.                 ..|:.|.:..|..|..|...|
Human  1765 L-SEVKVQPGC-----------------YLPSNPEAIVLDIDYKSGTPM---------------- 1795

  Fly   536 FLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYN 600
               |.|.....||.:                                  ||...|
Human  1796 ---QSAAKAPYLAKF----------------------------------KVKRCG---------- 1813

  Fly   601 LRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKI 665
                   :.||.|        .|.|.:...:.:....|.|..|:::
Human  1814 -------VSELEK--------EGLRCRSDSEDECSTQEADGQKISW------------------- 1844

  Fly   666 VPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLT 730
                                       .|||||.|||.|||.|.||:|.|...:.:...|||.:.
Human  1845 ---------------------------QAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVF 1882

  Fly   731 PYKVLATSSKHGFLQYVDSCTVAEVLAREGN--IHNFFRKHHPCDNGPYGISA-----EVMDTYI 788
            ||:|:||:...|.::.:..||..:.|.|:.:  ::::|.:.       ||..:     :....:|
Human  1883 PYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQ-------YGDESTLAFQQARYNFI 1940

  Fly   789 KSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDP---KPMPPPMKLSKEMVEAMG 850
            :|.|.|.::.:||.:.|||..|::|...|.:.|||||::....|   ....|.:||:.|||..||
Human  1941 RSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMG 2005

  Fly   851 G-ISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTD 914
            | :.:.....|.:.|...||.:|.:.:.:::|.:||:|..:|...   .:.:|.::......:|:
Human  2006 GKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFR---GQTIKLLKHRFSPNMTE 2067

  Fly   915 EEAVQHLQSLL 925
            .||...:..::
Human  2068 REAANFIMKVI 2078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	32/170 (19%)
		PI3Ka_III	284..561	CDD:238442	66/322 (20%)
		PI3Kc_III	601..945	CDD:270628	81/336 (24%)
PI4KA	NP_477352.3	PI4Ka	1547..1722	CDD:238443	43/179 (24%)
		PI4Kc_III_alpha	1783..2101	CDD:270711	92/430 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810