DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and PIK3CG

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001269355.1	Gene:	PIK3CG / 5294	HGNCID:	8978	Length:	1102	Species:	Homo sapiens

Alignment Length:	988	Identity:	225/988 - (22%)
Similarity:	378/988 - (38%)	Gaps:	326/988 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 HERVQIKVGTLEGKKRQPDYEKLLED--------------PIL-RFSGLYSEEHPSFQVRLQVFN 66
            ||::     |:.||..:..:...|.|              |:| |.:.|......:.|...||..
Human   336 HEQL-----TIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLC 395

  Fly    67 QGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGA-------------- 117
            |.|       :|.|.|.:...||.|:...::..|||:.|:|.|.|. |..|
Human   396 QRR-------TSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIY-CGKAPALSSKASAESPSS 452

  Fly   118 ---GQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLA 179
               |:..::...::.:.....:.|:|.|.|.:|           :..|||::.......:|....
Human   453 ESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMW-----------QISGKGEDQGSFNADKLTSAT 506

  Fly   180 KKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVK 244
            ..                        ::|..||..:.|          |.|.:.:
Human   507 NP------------------------DKENSMSISILL----------DNYCHPI---------- 527

  Fly   245 YKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDR-DAKPTASIRDQLHTIVYRYPPTY 308
                |.||....||.|                      .|| .|:....:|.||..|: ...|..
Human   528 ----ALPKHQPTPDPE----------------------GDRVRAEMPNQLRKQLEAII-ATDPLN 565

  Fly   309 VLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLAN---W--APMDVEDALEL 368
            .|::|:::|:|.||:....|.||..|....:.|..::.|.:...:||.   |  :.:||...::|
Human   566 PLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQL 630

  Fly   369 LSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDD 433
            |...|:...||..||.:|....|:|:|.||||||||:|:| |.|
Human   631 LDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFE-PYH--------------------- 673

  Fly   434 NGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNP 498

Human   674 ----------------------------------------------------------------- 673

  Fly   499 SAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVE 563
                         ||                  .|..||::|...|..:.::.:|:|..|:
Human   674 -------------DS------------------ALARFLLKRGLRNKRIGHFLFWFLRSEI---- 703

  Fly   564 SVRKQDERAHDMYAMVLKMFLKVLENGNFNLRG----IFYNLRKQRRFIDELVKL---VKLVAKE 621
               .|.......:|::|:.:          |||    :.::..:|.:.|:.|.|:   :|.::.|
Human   704 ---AQSRHYQQRFAVILEAY----------LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAE 755

  Fly   622 PGNRNKKT-----EKFQKLLAEQ--DMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMP 679
            ..:.:.:.     :|.:.|...|  :.|:|          |.||.:....:...:..:..|...|
Human   756 KYDVSSQVISQLKQKLENLQNSQLPESFRV----------PYDPGLKAGALAIEKCKVMASKKKP 810

  Fly   680 AKLTF----VTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSK 740
            ..|.|    .|::::.....|||||||||||.||||::.:|:.:...|:|||.|.||..::|..|
Human   811 LWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDK 875

  Fly   741 HGFLQYV-DSCTVAEV-LAREGN--------IHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYC 795
            .|.::.| |:.|:|:: .:..||        ::::.::..|.:.   ...|.| :.::.||||||
Human   876 IGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEE---KFQAAV-ERFVYSCAGYC 936

  Fly   796 VITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILG-----------RDPKPMPPPMKLSKEMVEAM 849
            |.|::||:||||.||:::|..|.|||||||:|||           |.|..:.|....   ::...
Human   937 VATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLF---VMGTS 998

  Fly   850 GGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTD 914
            |..:|.|..:|:..|..|||.||.|.|:::.|||:|:...:|.:..:.|  ::.:.:.|.:|..:
Human   999 GKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKED--IEYIRDALTVGKNE 1061

  Fly   915 EEAVQHLQSLLDV 927
            |:|.::....::|
Human  1062 EDAKKYFLDQIEV 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	38/190 (20%)
		PI3Ka_III	284..561	CDD:238442	58/282 (21%)
		PI3Kc_III	601..945	CDD:270628	108/362 (30%)
PIK3CG	NP_001269355.1	PI3K_rbd	203..312	CDD:197540
		C2_PI3K_class_I_gamma	350..527	CDD:176044	42/229 (18%)
		PI3Ka_I	549..725	CDD:238444	61/311 (20%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	108/365 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820