Protein Alignment Pi3K59F and PIK3CD

DIOPT Version :10

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_005017.3
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1044
• Species: Homo sapiens
• Alignment Length: 996
• Identity: 229/996 - (22%)
• Similarity: 376/996 - (37%)
• Gaps: 332/996 - (33%)

  Fly     7 HFRYIHSSSL-------------HERVQIKVGTLEGKKRQPDYEKL--LEDP----ILRFSGLYS 52
            |...:||||:             .::.:.|...:..||  |....|  ||.|    :::.|.:.:
Human   273 HLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKK--PSSVSLWSLEQPFRIELIQGSKVNA 335

  Fly    53 EEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAML---VLTILDC 114
            :|.....|:..:|:.....|..|:||..:......|.:.:...:...||||.|.|   :..:::.
Human   336 DERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEK 400

  Fly   115 SGAGQTT---------VIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKS 170
            :...::|         .|...::.:|......:.|...|.:|         ||....||
Human   401 AKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMW---------PSVPDEKG------ 450

  Fly   171 QMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINE----REKRMSD-YMFLMIEFPAIVVDDMY 230
                                           |::|.    |....:| ...|:|..|.:....:|
Human   451 -------------------------------ELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVY 484

  Fly   231 NYAVVYFEPEGDVKYKLPAKPKLVSV----------PDSEIQMENLVERKHHRLARSERSGISDR 285
                            .||..|::.:          .:.::|:..::||:        .||
Human   485 ----------------YPALEKILELGRHSECVHVTEEEQLQLREILERR--------GSG---- 521

  Fly   286 DAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSH-KKALTKFLKCINWKLEDEVTQ 349
                                   .|...|:|||||.|..:..| .:||.:.|....|...::|.|
Human   522 -----------------------ELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQ 563

  Fly   350 ALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIV 414
            .|::|.:|..:.|..|||||..:|....|..:|:..|.:..|::|..|||||||.||||
Human   564 MLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYE------ 622

  Fly   415 HLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSP 479
                                                                             
Human   623 ----------------------------------------------------------------- 622

  Fly   480 GSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTN 544
                                       |.|.|:                    |..||:.||..|
Human   623 ---------------------------SYLDCE--------------------LTKFLLDRALAN 640

  Fly   545 ATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLR---KQRR 606
            ..:.::.:|:|..|: .|.||..:       :.::|:.:          .||..::::   ||..
Human   641 RKIGHFLFWHLRSEM-HVPSVALR-------FGLILEAY----------CRGSTHHMKVLMKQGE 687

  Fly   607 FIDELVKL---VKLVA-KEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVP 667
            .:.:|..|   |||.: |.|   ..:|::...|...|:.:....::.:.   ||||...:.::..
Human   688 ALSKLKALNDFVKLSSQKTP---KPQTKELMHLCMRQEAYLEALSHLQS---PLDPSTLLAEVCV 746

  Fly   668 MRTSLFKSALMPAKLTFVTSIAHH--EYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLT 730
            .:.:...|.:.|..:.:....|..  ....|||:|||||||.|.||||.|||.|.::|.|||::|
Human   747 EQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMT 811

  Fly   731 PYKVLATSSKHGFLQYV-DSCTVAEVLAREGN-----------IHNFFRKHHPCDNGPYGISAEV 783
            ||..|.|..:.|.::.| .|.|:|.:...:.|           :.|:.:..:|         .|.
Human   812 PYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNP---------GEA 867

  Fly   784 MDTYIK----SCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPM-----PPPM 839
            :|..|:    |||||||.||:||:||||.||:::..:|:|||||||:.||......     ..|.
Human   868 LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPF 932

  Fly   840 KLSKEMVEAM--GGI-SSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAV 901
            .|:.:.|..:  |.. :||....||..|..||..||||..:.|:||:||..|.:|:::...|  :
Human   933 ILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKD--I 995

  Fly   902 KKVEENLQLGLTDEEAVQHLQ 922
            :.::::|.||.|:|||::|.:
Human   996 QYLKDSLALGKTEEEALKHFR 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	32/176 (18%)
		PI3Ka_III	284..561	CDD:238442	53/277 (19%)
		PI3Kc_III	601..945	CDD:270628	116/355 (33%)
PIK3CD	NP_005017.3	PI3K_p85B	34..107	CDD:460483
		PI3K_rbd	175..281	CDD:395642	3/7 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..312		3/26 (12%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	36/212 (17%)
		PI3Ka	503..684	CDD:214537	64/351 (18%)
		PI3Kc_IA_delta	676..1042	CDD:270718	116/358 (32%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	751..757		1/5 (20%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	890..898		5/7 (71%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	909..935		8/25 (32%)